E7
E7蛋白具有转化活性和反式激活活性。 结构为两个功能区域：一个是N末端区域，含有保守的Cys-X-X-Cys（CXXC）结构，用于与细胞中的特定蛋白质相互作用；另一个是C末端区域，包含保守的LXCXE序列，用于与细胞中的Rb蛋白（Retinoblastoma protein）结合。E7蛋白通过与细胞中的Rb蛋白结合，抑制Rb蛋白的功能，导致细胞周期的失控和异常增殖。这会使细胞失去正常的生长抑制机制，促进细胞转变和癌变。E7靶点及其与Rb蛋白相互作用的研究已成为HPV相关癌症治疗和疫苗研发的重要方向，是HPV感染中的关键蛋白之一，它与细胞周期调控、转录调控和细胞增殖等过程密切相关。
热销产品
● Recombinant Human papillomavirus type 16 Protein E7 (E7)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP365855HML could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) E7.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP365855HML could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) E7.
● Recombinant Human papillomavirus type 18 Protein E7 (E7)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
E7 Antibodies
E7 for Human papillomavirus type 18
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA361948LA01HMN | E7 Antibody | Human papillomavirus type 18 | ELISA |
E7 Proteins
E7 Proteins for Human papillomavirus type 18
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP361948HMN | Recombinant Human papillomavirus type 18 Protein E7 (E7) | Yeast |
| CSB-EP361948HMN | Recombinant Human papillomavirus type 18 Protein E7 (E7) | E.coli |
| CSB-BP361948HMN CSB-MP361948HMN CSB-EP361948HMN-B |
Recombinant Human papillomavirus type 18 Protein E7 (E7) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
