Efna5
肝配蛋白A5（Ephrin A5，EFNA5）是受体酪氨酸激酶家族（RTKs）成员之一，定位于细胞膜，在皮肤、脑、脾、肾脏、心脏和脂肪中均有较高表达。酪氨酸激酶受体Eph及其膜结合配体Ephrin家族是发育相关神经生长抑制因子，在神经发育过程中的许多环节发挥着重要作用。它们激活突触双向信号通路激发突感的可塑性，调控局部神经元的投射、突触重塑、功能建立及干细胞的增殖分化迁移过程。Ephrin A5（EFNA5）是此家族配体中的研究热点之一。EFNA5能够与其受体结合发挥重要的生理功能，如参与神经发生、血管生成、促进细胞增殖与分化、平衡葡萄糖稳态、维持晶状体发育、调控雌性哺乳动物生殖、动员脂肪产热等等。新近研究发现Ephrin A5/EphA4可调控TrkB/PI-3K/Akt通路，与难治性癫痫慢性期自发性痫性发作机制相关。
Recombinant Human EFNA5 活性蛋白实验验证数据
SDS-PAGE
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized EPHA3(CSB-MP007723HU) at 2 μg/ml can bind human EFNA5, the EC50 of human EFNA5 protein is 0.8674-1.119 ng/ml.
Human EPHA3 protein his tag (CSB-MP007723HU) captured on COOH chip can bind Human EFNA5 protein Fc tag (CSB-MP007464HU) with an affinity constant of 13.8 nM as detected by LSPR Assay.
Efna5 Antibodies
Efna5 for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA007464LC01RA | Efna5 Antibody, FITC conjugated | Rat | |
| CSB-PA007464LA01RA | Efna5 Antibody | Rat | ELISA |
Efna5 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA905708 | EFNA5 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA000065 | EFNA5 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA002375 | EFNA5 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA498240 | EFNA5 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA977329 | EFNA5 Antibody | Human,Mouse,Rat | ELISA,IHC |
Efna5 Proteins
Efna5 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007464RA | Recombinant Rat Ephrin-A5 (Efna5) | Yeast |
| CSB-EP007464RA | Recombinant Rat Ephrin-A5 (Efna5) | E.coli |
| CSB-BP007464RA CSB-MP007464RA CSB-EP007464RA-B |
Recombinant Rat Ephrin-A5 (Efna5) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Efna5 Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007464CH CSB-EP007464CH CSB-BP007464CH CSB-MP007464CH CSB-EP007464CH-B |
Recombinant Chicken Ephrin-A5 (EFNA5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Efna5 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007464HU CSB-EP007464HU CSB-BP007464HU CSB-EP007464HU-B |
Recombinant Human Ephrin-A5 (EFNA5) | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP007464HU | Recombinant Human Ephrin-A5 (EFNA5) (Active) | Mammalian cell |
Efna5 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007464MO CSB-EP007464MO CSB-BP007464MO CSB-MP007464MO CSB-EP007464MO-B |
Recombinant Mouse Ephrin-A5 (Efna5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
