Erbb2
人表皮生长因子受体2（HER2，也称ERBB2）是表皮生长因子受体家族中的一员。HER2具有酪氨酸激酶活性，在组织发育中起至关重要的作用，是胚胎发育所必需的。然而，HER2的过表达往往会引起正常生物学功能的紊乱。ERBB2尚没有已知的配体，必须与家族其他成员组成同源或异源二聚体，激活胞内的酪氨酸激酶活性，从而启动下游信号传导通路RAS-RAF-MEK-ERK以及PI3K-AKT-mTOR通路。越来越多的研究发现HER2与多种癌症相关，包括乳腺癌、胃癌、结肠癌、膀胱癌、卵巢癌、子宫内膜癌、肺癌等。其中，HER-2在乳腺癌和胃癌中的研究最为成熟。目前，HER2靶向药物治疗乳腺癌已取得显著的临床疗效，数据表明曲妥珠单抗，T-DM1，帕妥珠单抗在治疗过表达HER2的乳腺癌中，对患者预后有显著的改善作用。此外，针对胃癌、结直肠癌的研究也在进行中。
热销产品
● Recombinant Human Receptor tyrosine-protein kinase erbB-2(ERBB2),partial (Active)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.
● ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA1HU
验证数据
The Binding Activity of Human ERBB2 with Anti-ERBB2 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ERBB2 (CSB-MP007763HU) at 2 μg/mL can bind Anti-ERBB2 recombinant antibody, the EC50 is 2.455-3.565 ng/mL.
● ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA2HU
验证数据
IHC image of CSB-RA007763MA2HU diluted at 1:600 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.
Erbb2 Antibodies
Erbb2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA007763GA01HU | ERBB2 Antibody | Human | ELISA,WB,IHC |
| CSB-PA09759C0Rb | ERBB2 Antibody, FITC conjugated | Human | |
| CSB-PA09759D0Rb | ERBB2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA007763KA01HU | ERBB2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA09759B0Rb | ERBB2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA09759A0Rb | ERBB2 Antibody | Human | ELISA, IHC |
| CSB-PA846722 | Phospho-ERBB2 (Tyr877) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA281422 | Phospho-ERBB2 (Tyr1221/Tyr1222) Antibody | Human | ELISA,WB,IF |
| CSB-PA997735 | Phospho-ERBB2 (Tyr1248) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA200841 | ERBB2 (Ab-877) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA899547 | ERBB2 (Ab-1221/1222) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA115264 | ERBB2 (Ab-1248) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA761682 | Phospho-ERBB2 (Tyr1112) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000577 | Phospho-ERBB2 (Y1221/Y1222) Antibody | Human,Mouse,Rat | WB, IHC, IP, ELISA |
| CSB-PA000578 | Phospho-ERBB2 (Y877) Antibody | Human,Mouse,Rat | WB, IHC, IP, ELISA |
| CSB-PA000733 | Phospho-ERBB2 (Y1221/Y1222) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IF, ELISA |
| CSB-PA003405 | ERBB2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA003407 | ERBB2 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008077 | Phospho-ERBB2 (Y1248) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA008078 | Phospho-ERBB2 (Y1112) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008079 | Phospho-ERBB2 (T686) Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA008081 | ERBB2 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008088 | ERBB2 Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA008089 | ERBB2 Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA008092 | ERBB2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA972166 | ERBB2 Antibody | Human | ELISA,WB |
| CSB-RA260392A0HU | ERBB2 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
Erbb2 for H, M, R
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-MA000200 | ERBB2 Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
Erbb2 for H
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-MA000237 | ERBB2 Monoclonal Antibody | Human | ELISA,WB |
Erbb2 Proteins
Erbb2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007763MO CSB-EP007763MO CSB-BP007763MO CSB-MP007763MO CSB-EP007763MO-B |
Recombinant Mouse Receptor tyrosine-protein kinase erbB-2 (Erbb2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Erbb2 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007763RA CSB-EP007763RA CSB-BP007763RA CSB-MP007763RA CSB-EP007763RA-B |
Recombinant Rat Receptor tyrosine-protein kinase erbB-2 (Erbb2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Erbb2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007763HU CSB-BP007763HU CSB-EP007763HU-B |
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP007763HU1 | Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial | E.coli |
| CSB-EP007763HU | Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial | E.coli |
| CSB-EP007763HU3 | Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial | E.coli |
| CSB-MP007763HU | Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) | Mammalian cell |
Erbb2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007763DO CSB-EP007763DO CSB-BP007763DO CSB-MP007763DO CSB-EP007763DO-B |
Recombinant Dog Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Erbb2 Proteins for Mesocricetus auratus (Golden hamster)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP736718MRG CSB-EP736718MRG CSB-BP736718MRG CSB-MP736718MRG CSB-EP736718MRG-B |
Recombinant Mesocricetus auratus Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Erbb2 ELISA Kit
Erbb2 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E11161h | Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.04 ng/mL |
