LAG3

LAG-3是一种具有免疫抑制功能的跨膜蛋白，其结构由胞外区的四个免疫球蛋白超家族结构域、跨膜区和胞内区的丝氨酸磷酸化位点等关键元件组成。功能上，LAG-3主要通过与配体如MHC II、半乳糖凝集素-3等的相互作用，抑制T细胞的激活和细胞因子分泌，从而维持免疫稳态。在信号通路方面，LAG-3与其配体结合后，通过胞内结构域与下游信号分子的相互作用，调节T细胞的活化状态。在肿瘤治疗中，LAG-3作为重要靶点，通过阻断或抑制LAG-3可增强T细胞对肿瘤的杀伤作用。因此，深入研究LAG-3的结构、功能和信号通路，对于开发新的免疫疗法具有重要意义。

热销产品

LAG3 Antibody

验证数据

Positive WB detected in: HepG2 whole cell lysate
All lanes: LAG3 antibody at 4.9µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 58, 40 kDa
Observed band size: 58 kDa

Immunofluorescence staining of HepG2 cells with CSB-PA012719LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

LAG3 Antibody

LAG3 Protein

LAG3 ELISA Kit

LAG3 Antibodies

LAG3 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA012719GA01HU	LAG3 Antibody	Human,Mouse	ELISA,WB
CSB-PA012719LA01HU	LAG3 Antibody	Human	ELISA, WB, IF
CSB-PA012719LC01HU	LAG3 Antibody, FITC conjugated	Human
CSB-PA012719LD01HU	LAG3 Antibody, Biotin conjugated	Human	ELISA
CSB-PA005868	LAG3 Antibody	Human	WB, ELISA
CSB-PA172061	LAG3 Antibody	Human	ELISA,WB
CSB-MA012719A0m	LAG3 Monoclonal Antibody	Human	ELISA, WB, IHC, FC

LAG3 Proteins

LAG3 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP012719HU1 CSB-BP012719HU1 CSB-MP012719HU1 CSB-EP012719HU1-B	Recombinant Human Lymphocyte activation gene 3 protein (LAG3), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP012719HU1	Recombinant Human Lymphocyte activation gene 3 protein (LAG3), partial	E.coli
CSB-CF012719HU	Recombinant Human Lymphocyte activation gene 3 protein (LAG3)	in vitro E.coli expression system