MASP2
MASP2，即甘露聚糖结合凝集素相关丝氨酸蛋白酶2，它是由人体编码的蛋白质，属于补体系统的一部分。MASP2主要来源于肝脏，是凝集素途径中的关键效应酶。其作用机制是在凝集素途径激活后，MASP2被甘露糖结合凝集素（MBL）或其他模式识别分子激活，进而裂解C4和C2，形成C3转化酶，激活C3和C5，最终导致形成膜攻击复合物（MAC），发挥溶细胞效应。在信号通路方面，MASP2的激活是补体系统凝集素途径的中心环节，通过其丝氨酸蛋白酶活性，MASP2参与调控免疫反应和炎症过程。在生物学意义上，MASP2对宿主的免疫防御至关重要，其功能异常与多种炎症性疾病和自身免疫性疾病的发生发展相关。MASP2的活性调节为治疗相关疾病提供了新的策略。
热销产品
Recombinant Human Mannan-binding lectin serine protease 2 (MASP2) (CSB-EP013510HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MASP2 Antibody (CSB-PA013510LA01HU)
验证数据
IHC image of CSB-PA013510LA01HU diluted at 1:100 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Human mannan-binding lectin serine peptidase 2 (MASP2)ELISA kit (CSB-E17966h)
验证数据
货号：CSB-E17966h
规格：96T/48T
灵敏度：5.86 pg/mL
检测范围：23.44 pg/mL-1500 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
MASP2 Antibodies
MASP2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA943074 | MASP2 Antibody | Human | ELISA,WB |
| CSB-PA006707 | MASP2 Antibody | Human | WB, ELISA |
| CSB-PA178736 | MASP2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA159806 | MASP2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA013510LA01HU | MASP2 Antibody | Human | ELISA, IHC |
| CSB-PA013510LB01HU | MASP2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA013510LC01HU | MASP2 Antibody, FITC conjugated | Human | |
| CSB-PA013510LD01HU | MASP2 Antibody, Biotin conjugated | Human | ELISA |
MASP2 Proteins
MASP2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP013510HU CSB-MP013510HU CSB-EP013510HU-B |
Recombinant Human Mannan-binding lectin serine protease 2 (MASP2) | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-BP013510HU | Recombinant Human Mannan-binding lectin serine protease 2 (MASP2) | Baculovirus |
| CSB-EP013510HU | Recombinant Human Mannan-binding lectin serine protease 2 (MASP2) | E.coli |
MASP2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP856307MO CSB-MP856307MO CSB-EP856307MO-B |
Recombinant Mouse Mannan-binding lectin serine protease 2 (Masp2) | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP856307MO | Recombinant Mouse Mannan-binding lectin serine protease 2 (Masp2) | E.coli |
| CSB-BP856307MO | Recombinant Mouse Mannan-binding lectin serine protease 2 (Masp2) | Baculovirus |
| CSB-BP856307MOc7 | Recombinant Mouse Mannan-binding lectin serine protease 2 (Masp2) | Baculovirus |
MASP2 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP867502RA CSB-EP867502RA CSB-EP867502RA-B |
Recombinant Rat Mannan-binding lectin serine protease 2 (Masp2) | Yeast E.coli In Vivo Biotinylation in E.coli |
| CSB-BP867502RA | Recombinant Rat Mannan-binding lectin serine protease 2 (Masp2) | Baculovirus |
MASP2 ELISA Kit
MASP2 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E17966h | Human mannan-binding lectin serine peptidase 2 (MASP2)ELISA kit | serum, plasma, cell culture supernates, cerebrospinal fluid (CSF) | 5.86 pg/mL |
MASP2 ELISA Kit for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL013510MO | Mouse Mannan-binding lectin serine protease 2(MASP2) ELISA kit | serum, plasma, tissue homogenates | 31.2 pg/mL |
