SIRPA
信号调节蛋白α（SIRPα，也称为CD172a）是一类广泛表达的糖蛋白分子，属于免疫球蛋白超家族结构域。SIRPα在髓系造血细胞（如巨噬细胞、树突状细胞）和神经细胞表面均有表达；而其配体CD47，也称整合素相关蛋白(integrin-associated protein，IAP)，广泛表达于几乎所有正常细胞的表面。SIRPα与其他细胞上的CD47结合后，可向巨噬细胞传递抑制性信号，抑制巨噬细胞对靶细胞的吞噬作用。因此，这条通路可用来识别己细胞（self）与非己细胞（non-self）。一些肿瘤细胞利用这个机制，高表达CD47来向巨噬细胞发出“别吃我（Don’t eat me）”信号，来进行免疫逃逸。作为一个热门的免疫抑制性信号通路，目前有多种靶向Sirpα和/或CD47免疫检查点的抗体设计策略, 包括全长抗体、F(ab)、与Fc融合的F(ab)等。
Recombinant Human SIRPA 活性蛋白实验验证数据
CSB-MP015007HU is detected by Mouse anti-6*His monoclonal antibody.
Measured by its binding ability in a functional ELISA. Immobilized SIRPA at 2 μg/ml can bind human CD47(CSB-MP004940HU), the EC50 of human SIRPA protein is 58.30-85.04 ng/ml.
Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.
SIRPA Antibodies
SIRPA for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA021334GA01HU | SIRPA Antibody | Human | ELISA,WB |
| CSB-PA021334LB01HU | SIRPA Antibody, HRP conjugated | Human | ELISA |
| CSB-PA021334LC01HU | SIRPA Antibody, FITC conjugated | Human | |
| CSB-PA021334LD01HU | SIRPA Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA021334LA01HU | SIRPA Antibody | Human | ELISA, IHC, IF |
| CSB-PA004094 | SIRPA Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
SIRPA Proteins
SIRPA Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP021334HU CSB-BP021334HU CSB-EP021334HU-B |
Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP021334HU1 | Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA), partial | E.coli |
| CSB-CF021334HU | Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA) | in vitro E.coli expression system |
| CSB-AP005271HU | Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA), partial (Active) | Mammalian cell |
| CSB-MP021334HUh6 | Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA), partial | Mammalian cell |
| CSB-MP021334HU | Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA), partial (Active) | Mammalian cell |
| CSB-EP3582HU | Recombinant Human variant SIRP alpha (SIRPA) | E.coli |
SIRPA Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP021334MO1 CSB-EP021334MO1 CSB-BP021334MO1 CSB-MP021334MO1 CSB-EP021334MO1-B |
Recombinant Mouse Tyrosine-protein phosphatase non-receptor type substrate 1 (Sirpa), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF021334MO | Recombinant Mouse Tyrosine-protein phosphatase non-receptor type substrate 1 (Sirpa) | in vitro E.coli expression system |
SIRPA Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP021334RA1 CSB-EP021334RA1 CSB-BP021334RA1 CSB-MP021334RA1 CSB-EP021334RA1-B |
Recombinant Rat Tyrosine-protein phosphatase non-receptor type substrate 1 (Sirpa), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF021334RA | Recombinant Rat Tyrosine-protein phosphatase non-receptor type substrate 1 (Sirpa) | in vitro E.coli expression system |
SIRPA Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP021334BO1 CSB-EP021334BO1 CSB-BP021334BO1 CSB-MP021334BO1 CSB-EP021334BO1-B |
Recombinant Bovine Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF021334BO | Recombinant Bovine Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA) | in vitro E.coli expression system |
SIRPA ELISA Kit
SIRPA ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL021334HU | Human Tyrosine-protein phosphatase non-receptor type substrate 1(SIRPA) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 0.039 ng/mL |
