ULBP1

UL16结合蛋白-1（UL16-binding protein 1，ULBP1）又称NKG2DL，属于ULBPs家族的成员，是NKG2D的配体之一。而NKG2D是免疫效应细胞上表达的一种活化性受体，能够识别不同的MHC-I类相关分子MHCA、MHCB和另一类MHC-I类相关分子ULBPs，这些配体在正常细胞中不常见，在病毒感染、肿瘤恶性转化等条件下诱导表达。ULBP1配体可激活自然杀伤细胞（NK）和CD8+T细胞的NKG2D受体，从而触发免疫杀伤。研究人员发现，ULBP1在子痫前期（PE）患者外周血外泌体中的高表达，可能会为PE的诊治提供一定依据。此外，有关实验数据表明ULBP1在人类肝细胞癌（HCC）中大量表达。且NKG2D受体和ULBP1的表达与HCC炎性细胞的存在密切相关。另有研究提示，肝切除术后的早期复发与ULBP1的表达缺失密切相关。因此，ULBP1有望成为HCC免疫治疗的分子靶点。

Recombinant Human ULBP1 活性蛋白实验验证数据

High Purity Validated
by SDS-PAGE

CSB-MP015007HU is detected by Mouse anti-6*His monoclonal antibody.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized KLRK1 (CSB-MP012474HU1) at 10 μg/ml can bind human ULBP1, the EC₅₀ of human ULBP1 protein is 228.5-427.6 ng/ml.

Excellent Bioactivity Validated by LSPR Assay

Human KLRK1 protein Fc tag (CSB-MP012474HU1) captured on COOH chip can bind Human ULBP1 protein Fc/myc tag (CSB-MP887177HU) with an affinity constant of 2.27 nM as detected by LSPR Assay.