Human α-subunits of hemoglobin(HB-α) ELISA Kit

1. Relatively high but clinically normal HbA1c and TSH levels may increase the risk of CHD. PMID: 28345646
2. Vaginal cell-derived Hb-alpha and Hb-beta may have antioxidative properties and protect cells from oxidative stress-induced inflammation possibly through Nrf2 downstream signaling. PMID: 28224676
3. Data suggest that, in crystal form of Hb containing three protein molecules--Hbalpha(1)beta(2), allosteric effectors (phosphate, bezafibrate) induce conformational changes in direction from relaxed-state to tense-state; binding of each effector energetically stabilizes lowest affinity conformer more strongly than intermediate affinity conformer; minor Hb conformers have disproportionate effects on overall O(2) affinity. PMID: 28931607
4. In the presence of free alpha subunits and H2O2, both HbA and HbE showed bCys93 oxidation which increased with higher H2O2 concentrations. In the presence of Alpha-hemoglobin stabilizing protein (AHSP)Cys93 oxidation was substantially reduced in both proteins.in the presence of excess free alpha-subunit and under the same oxidative conditions, these events are substantially increased for HbE compared to HbA PMID: 26995402
5. genome-wide association meta-analyses in individuals from 82 cohorts of European, African, East Asian and South Asian ancestry; identified 60 common genetic variants associated with HbA1c; 19 glycemic (GS-G) and 22 erythrocytic (GS-E) variants were associated with HbA1c at genome-wide significance; GS-G was associated with higher type 2 diabetes risk; GS-E was not PMID: 28898252
6. This study presents comparison of two neutron structures of hemoglobins, human deoxyhemoglobin (T state) and equine cyanomethemoglobin (R state) and offers a direct observation of histidine residues that are likely to contribute to the Bohr effect. PMID: 27377386
7. Dynamical differences of hemoglobin and the ionotropic glutamate receptor in different states have been revealed by a new dynamics alignment method. PMID: 28459140
8. The studies suggest that impaired endocytosis of megalin/cubilin ligands, hemoglobin and albumin, rather than heme toxicity, may be the cause of tubular proteinuria in sickle cell disease patients. PMID: 28356267
9. Report association between HbA1c levels in diabetes mellitus type 2 in relation to the development of heart failure. PMID: 27647169
10. Lower extremity amputation among patients with diabetes nearly halved over the past decade but only weakly correlated with hemoglobin A1c testing throughout the study period. PMID: 27206471
11. A 1 % increase in HbA1c was associated with a higher risk for all-cause mortality in patients with type 2 diabetes and symptomatic cardiovascular disease PMID: 27431507
12. 14 alpha thalassemia mutations were found among 95 Turkish patients. Most were gene deletions. A new alpha 1 cd 14 mutation was discovered. PMID: 26377141
13. The hematological and molecular data of 35 patients with Hb H disease and the genotypes of alpha-gene mutations of 78 screened individuals were used to identify the genotypes of Hb H disease and genotype-phenotype correlations. the most common genotypes were -alpha3.7/--20.5, -alpha3.7/--26.5, and -alpha3.7/--17.5. Other small deletions, non-deleltional mutations, and combinations thereof in trans were associated with... PMID: 26316481
14. that there is a quantitative relationship between the HbA1c levels and plaque textures in ultrasonic images of atherosclerotic patients PMID: 27431674
15. An association has been found between the TXNIP gene methylation pattern and type 2 diabetes mellitus in ischemic stroke patients through epigenetic mechanisms, related to sustained hyperglycemia levels with HbA1c >/= 7%. PMID: 26643952
16. People with new-onset diabetes mellitus based on HbA1c had higher mean hs-CRP level. PMID: 26824043
17. This study describes hematological manifestations of subjects carrying some novel mutations comparable to the reported phenotype of alpha(+)-thal trait. PMID: 26531168
18. The effect of the DPP-4 inhibitor alogliptin on HbA1c. PMID: 26125284
19. Data suggest considering HbA1c as a reliable marker of cardiovascular and metabolic risk independent of fasting and post-load glycemia. PMID: 26520892
20. Visceral fat area is associated with HbA1c but not dialysate-related glucose load in nondiabetic peritoneal dialysis patients. PMID: 26239161
21. The most deleterious non-coding synonymous SNPs in the alpha-thalassemia HBA1 gene have been characterized in silico. PMID: 26824843
22. The carrier rate of Hb Q-Thailand in Guangxi was 0.06%. PMID: 27060306
23. In multivariable linear regression analyses, DeltaGA/HbA1c was independently associated with diabetes duration. In conclusion, this study demonstrated that serum GA levels increase relative to HbA1c levels with time. PMID: 26484352
24. Poorer glucose control with HbA1C >/= 8% and decreased systolic heart function are significant risk factors that potentially contribute to worse prognosis for CABG or PCI treatment. PMID: 26261612
25. In middle-aged Caucasian-Europeans, HbA1c alone is a poor indicator of cardiometabolic risk but is suitable for diagnosing diabetes. PMID: 26266799
26. The lack of association between known risk factors for diabetes and HbA1c suggest that HbA1c in children without diabetes is relatively unaffected by factors associated with glycaemia. PMID: 25875773
27. Data indicate that amplification, detection and analysis of targets in the alpha-globin genes (HBA1 and HBA2) by ratio assay copy enumeration (GRACE) PCR method completed within one hour. PMID: 26683685
28. In a chronic kidney disease cohort, HbA1c values in the prediabetes range are associated with mortality. PMID: 25979978
29. Both HbA1c and glycated albumin levels reflect the risk of subclinical atherosclerosis in middle-aged and elderly Chinese with impaired glucose regulation. PMID: 25854289
30. Increase of HbA1c in patients with newly detected glucose abnormalities was associated with significantly reduced survival after AMI treated invasively. PMID: 24618476
31. Co-inheritance of novel ATRX gene mutation and alpha-globin/beta-globin gene mutations has been found in transfusion dependent beta-thalassemia Saudi Arabia patients. PMID: 25976463
32. Elevated mean platelet volume is significantly associated with higher HbA1c levels. PMID: 25249479
33. HbA1c has a role in increased risk of cardiovascular disease and all-cause death PMID: 25874454
34. In non-diabetic patients with suspected stable angina pectoris, there was no overall association between HbA1c levels and prognosis. PMID: 25770690
35. Insulin-naive diabetic patients with A1C>8.8%, especially those who are taking >2 oral antidiabetic agents, have small chance to achieve good glycemic control with adding only basal insulin therapy. PMID: 25266893
36. Although A1C is higher among type 2 diabetics with CKD stage 3 compared to those with eGFR >/=60, this appeared to be due to the confounding effect of other variables rather than the presence of CKD. PMID: 24893965
37. Higher fasting plasma glucose levels rather HbA1c were strongly predictive of future hypertension among Japanese population. PMID: 25231510
38. alpha1 gene sequencing showed the mutation CCT-->TCT (Pro-->Ser) at codon 119 (Hb Groene Hart) in alpha-thalassemia patients in Spain. In one case, there was an association with Hb J-Paris-I. PMID: 24530052
39. With the corrections proposed here, HbA1c measurements can be better interpreted as a diagnostic marker in the early weeks of antidiabetic treatment. PMID: 25158164
40. A new Hb variant was found in 4 diabetic patients. The alpha1 gene had a mutation GAC>AAC at codon 64 within exon 2. Substituting Asn for Asp does not produce any functional alteration, so it is a silent hemoglobinopathy. PMID: 25458507
41. Overall postoperative complication rate was similar regardless of preoperative HbA1c in pancreaticoduodenectomy patients, but pancreatic fistula incidence was lower with elevated versus normal HbA1c. PMID: 25242683
42. the first described case with homozygosity for the Hb Adana mutation, carried on the alpha1 gene. The relatively mild presentation of the case highlights the milder phenotypic consequences of nondeletional alpha mutations in the alpha1 vs. the alpha2 gene. PMID: 25342395
43. Abnormal hemoglobin with alpha-thalassemia may lead to severe anemia. PMID: 25863092
44. Data suggest co-inheritance of alpha-globin mutation/alpha-thalassemia alleviates severity of HBE-type beta-thalassemia in population of children/adolescents in Thailand; beta-thalassemia patients who co-inherited alpha-thalassemia had mild disease. PMID: 25238043
45. Hemoglobin A1C and glycemic variability were both associated with beta cell function in patients with newly diagnosed type 2 diabetes. PMID: 24762059
46. Data suggest two alpha-thalassemia patients and their family members exhibiting HbH disease spectrum exhibit two rare and unique alpha-globin gene cluster deletions (deletion of HBA1 and HBA2); families are described as Israeli Arabs. [CASE-REPORT] PMID: 25222045
47. Data suggest hemoglobin glycation in diabetic patients and normal subjects is consistent; seven glycation sites have been unambiguously assigned in alpha- and beta-globin; the two major sites are alpha-Lys-61 (HbA1c) and beta-Lys-66. PMID: 24578002
48. Elevated preoperative hemoglobin A1c levels are associated with an increased risk of readmission but not complications. PMID: 24887924
49. Presented are complete structural and functional snapshots of nine equilibrium conformers of hemoglobin in the half-liganded and fully liganded states. Captured is the hemoglobin allosteric transition in a single crystal form. PMID: 24635037
50. HbA1c levels lower than 6.0% and higher than 10% are associated with an increased risk of COPD in patients with type 2 diabetes. PMID: 25569658

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HGNC: 4823

OMIM: 140700

KEGG: hsa:3039

STRING: 9606.ENSP00000322421

UniGene: Hs.449630