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  4. Human Angiopoietin 4,ANG-4 ELISA Kit

Human Angiopoietin 4,ANG-4 ELISA Kit

  • 中文名称：
    人血管生成素4(ANG-4)酶联免疫试剂盒
  • 货号：
    CSB-E11182h
  • 规格：
    96T/48T
  • 价格：
    ￥3200/￥2500
  • 其他：

产品详情

  • 别名：
    AGP4 ELISA Kit; ANG-3 ELISA Kit; ANG-4 ELISA Kit; ANG3 ELISA Kit; ANG4 ELISA Kit; Angiopoietin 3 ELISA Kit; Angiopoietin 4 ELISA Kit; Angiopoietin-3 ELISA Kit; Angiopoietin-4 ELISA Kit; ANGP4_HUMAN ELISA Kit; ANGPT4 ELISA Kit; dJ824F16.2 (angiopoietin 4) ELISA Kit; MGC138181 ELISA Kit; MGC138183 ELISA Kit; OTTHUMP00000029947 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 检测范围：
    Request Information
  • 灵敏度：
    Request Information
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cardiovascular
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
  • 基因功能参考文献：
    1. Ang-4 also promoted survival of LECs. Thus, blocking Ang-4 may prune the draining lymphatic vasculature and decrease interstitial fluid pressure (IFP) by reducing vascular permeability. PMID: 25977256
    2. acute-phase protein A1AT is a physiological regulator of angptl4, another acute-phase protein. PMID: 24760148
    3. Angptl4 is a glucocorticoid-responsive mediator of fasting-induced intracellular lipolysis and stimulates cAMP signaling in adipocytes PMID: 22267746
    4. In tumor cells, only Ang-4 expression has prognostic impact in NSCLC. In NSCLC tumor stroma, Ang-4 and Ang-2 are independently associated with survival. PMID: 21603628
    5. Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer disease and vascular dementia is reported. PMID: 20596041
    6. Results establish the novel effects of Ang-4 on tumor angiogenesis and GBM progression and suggest that this pro-GBM effect of Ang-4 is mediated by promoting tumor angiogenesis and activating Erk1/2 kinase in GBM cells. PMID: 20823154
    7. the angiopoietin/Tie-2 system may participate in the angiogenic response to hypoxia in renal tissues and in tumor angiogenesis in renal carcinoma. PMID: 15198927
    8. Recombinant Ang4 formed disulfide-linked dimers. Ang4 produces corneal angiogenesis extending from the limbus across the mouse cornea in vivo. Ang4 is an agonist of Tie2. PMID: 15284220
    9. angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure PMID: 16790085
    10. Results describe the expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumors, leiomyomas and schwannomas. PMID: 17724803

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Highly expressed in the lung with much lower levels found in other tissues.
  • 数据库链接：

    HGNC: 487

    OMIM: 603705

    KEGG: hsa:51378

    STRING: 9606.ENSP00000371347

    UniGene: Hs.278973