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  4. ANGPT4 Antibody

ANGPT4 Antibody

  • 货号：
    CSB-PA584378
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA584378(ANGPT4 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA584378(ANGPT4 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human right lung tissue, Human left lung cancer tissue, Primary antibody: CSB-PA584378(ANGPT4 Antibody) at dilution 1/480, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y264
  • 基因名：
  • 别名：
    AGP4 antibody; ANG-3 antibody; ANG-4 antibody; ANG3 antibody; ANG4 antibody; Angiopoietin 3 antibody; Angiopoietin 4 antibody; Angiopoietin-3 antibody; Angiopoietin-4 antibody; ANGP4_HUMAN antibody; ANGPT4 antibody; dJ824F16.2 (angiopoietin 4) antibody; MGC138181 antibody; MGC138183 antibody; OTTHUMP00000029947 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human ANGPT4
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:200-1:1000
    IHC 1:100-1:300
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
  • 基因功能参考文献：
    1. Ang-4 also promoted survival of LECs. Thus, blocking Ang-4 may prune the draining lymphatic vasculature and decrease interstitial fluid pressure (IFP) by reducing vascular permeability. PMID: 25977256
    2. acute-phase protein A1AT is a physiological regulator of angptl4, another acute-phase protein. PMID: 24760148
    3. Angptl4 is a glucocorticoid-responsive mediator of fasting-induced intracellular lipolysis and stimulates cAMP signaling in adipocytes PMID: 22267746
    4. In tumor cells, only Ang-4 expression has prognostic impact in NSCLC. In NSCLC tumor stroma, Ang-4 and Ang-2 are independently associated with survival. PMID: 21603628
    5. Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer disease and vascular dementia is reported. PMID: 20596041
    6. Results establish the novel effects of Ang-4 on tumor angiogenesis and GBM progression and suggest that this pro-GBM effect of Ang-4 is mediated by promoting tumor angiogenesis and activating Erk1/2 kinase in GBM cells. PMID: 20823154
    7. the angiopoietin/Tie-2 system may participate in the angiogenic response to hypoxia in renal tissues and in tumor angiogenesis in renal carcinoma. PMID: 15198927
    8. Recombinant Ang4 formed disulfide-linked dimers. Ang4 produces corneal angiogenesis extending from the limbus across the mouse cornea in vivo. Ang4 is an agonist of Tie2. PMID: 15284220
    9. angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure PMID: 16790085
    10. Results describe the expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumors, leiomyomas and schwannomas. PMID: 17724803

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Highly expressed in the lung with much lower levels found in other tissues.
  • 数据库链接：

    HGNC: 487

    OMIM: 603705

    KEGG: hsa:51378

    STRING: 9606.ENSP00000371347

    UniGene: Hs.278973