Human Aquaporin 3,AQP-3 ELISA Kit

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism.

1. the present data suggest that expression of AQP3 and 5 may be a marker for distinguishing between patients with dry mouth and those with Sjogren's syndrome PMID: 29925705
2. Expression of AQP3 was markedly upregulated and miR-488 was significantly upregulated in osteosarcoma (OS) tissues and cell lines. miR488 inhibited the proliferation, invasion and epithelial-mesenchymal transition (EMT) of OS cells by directly downregulating AQP3 expression, and miR488 targeting AQP3 was responsible for inhibition of the proliferation, invasion and EMT of OS cells. PMID: 30015825
3. TFF peptides promptly produced at sites of injury increase AQP levels, most notably AQP3, thereby enhancing the cells' ability to rapidly change their shape as part of the restitutive process. TFF peptides also require functioning AQP3 channels to induce cell migration. PMID: 29046361
4. an altered expression of placental AQP3 may produce failures in placentation such as in preeclampsia. PMID: 29567477
5. Data show that AQP3 is localized largely in the cytoplasm and can be targeted to the plasma membrane in prostate cancer cells via a cAMP/PKA/RalA pathway. PMID: 29532894
6. placental expression reduced in pre-eclampsia PMID: 29108637
7. In response to injury, AQP3-depleted colonic epithelial cells showed defective lamellipodia, focal adhesions, and repair after wounding, along with impaired H2O2 responses after exposure to the intestinal pathogen Citrobacter rodentium. PMID: 28049834
8. AQP3 siRNA and PLD2 siRNA significantly downregulated the mRNA and protein levels of AQP3 and PLD2 in the A431 cells; inhibiting proliferation and promoting apoptosis in vitro. PMID: 28656282
9. Reduced epidermal AQP-3 may have a role in impaired melanocyte survival in vitiligo, and might be a potential negative biological marker for vitiligo activity PMID: 26923934
10. provide evidence for the involvement of the JNK pathway in AQP3 regulation in isolated oligohydramnios tissues in vitro, in amniotic epithelial cells derived from normal amniotic fluid and fluid from patients with isolated oligohydramnios PMID: 27814615
11. Results indicate that AQP3 promotes stem-like properties of gastric carcinoma (GC) cells by activating the Wnt/GSK-3beta/beta-catenin signaling pathway. PMID: 26918728
12. The Adiponectin increases AQP3 expression through PPARalpha-mediated signaling inhepatic stellate cells. PMID: 28595905
13. skin dryness observed in intrinsic and extrinsic aged skin may be explained, at least in part, by AQP3 downregulation. This may open new avenues sufficient to control skin texture and beauty. Its interaction in skin protein organization and gene polymorphism can also be tackled in future research PMID: 26509906
14. epigenetic signatures at AQP3 and SOCS3 engage in low-grade inflammation across different tissues, possible via JAK/STAT mediated pathways PMID: 27824951
15. RNA interference (RNAi) of aquaporin 3 (AQP3) retarded the growth and invasiveness of XWLC-05 lung cancer cells and decreased the activity of matrix metalloproteinase 2 (MMP2). PMID: 28189680
16. Taken together, our data, as a proof of principle, suggest that AQP3 can promote tumor growth of pancreatic cancer cells by activating the Mtor signaling pathway and provide a potential therapeutic target in the treatment of PDAC. PMID: 28377226
17. AQP3 was upregulated, and AQP7 and AQP9 were downregulated in hepatocellular carcinoma. A high expression of AQP3 and low expression of AQP7 was significantly associated with the aggressive features of hepatocellular carcinoma. PMID: 27121567
18. AQP3 inhibition that induced glycerol uptake reduction and glycerol administration would rehabilitate the cell proliferation. PMID: 26768614
19. AQP3 increases in hepatocellular carcinoma. Auphen reduces AQP3 levels, suppressing tumor growth. PMID: 27022216
20. roles of AQP-3 in AQP-3 aquaglyceroporin and ClC-3 chloride channels complex PMID: 26794461
21. treatment of human HepG2 cells with TCDD also increased the expression of AQP3 mRNA and protein PMID: 26454884
22. AQP3 knockdown retards the growth of NSCLC cells partially through inhibiting HIF-1alpha/VEGF and Raf/MEK/ERK signalling pathways. PMID: 26765123
23. AQP3 was found to be expressed in 67.71% of parts with GIM, and AQP3 immunoreactivity was identified more frequently in severe GIM areas (P < 0.001). In short, the incidence and severity of GIM correlated with the distance from GC, and AQP3 was differentially expressed in goblet cells, with most AQP3-positive goblet cells presenting in severe GIM. PMID: 26506416
24. AQP3 was expressed in trophoblast explants. Blocking it with CuSO4 prevented apoptosis. PMID: 26568619
25. Expression of CXCL4 and aquaporin 3 and 10 mRNAs in middle ear effusion is associated with the pathophysiology of otitis media with effusion. PMID: 26810286
26. results demonstrate that AQP3 is required for CXCL12-induced breast cancer cell signaling and directional migration by a mechanism involving the CXCL12-induced generation of extracellular H2O2 and subsequent intracellular transport by AQP3 PMID: 26830227
27. We, for the first time, identified an ERE in the promoter of AQP3 gene, and found that estrogen might promote breast cancer development through activating ERE in the promoter of AQP3 gene and upregulating AQP3 expression in ER-positive breast cancer. PMID: 26219409
28. these findings suggest that AQP3 is required for EGF-EGFR cell signaling in cancer cells and is a therapeutic target for cancer progression. PMID: 26896765
29. AQP3 may play a role in nonmelanoma skin cancer pathogenesis PMID: 26107428
30. the human aquaglyceroporins, i.e., AQP3, AQP7, AQP9 and AQP10 can act as silicon transporters in both Xenopus laevis oocytes and HEK-293 cells. PMID: 26313002
31. AQP3-facilitated H2O2 transport is required for NF-kappaB activation in keratinocytes in the development of psoriasis. PMID: 26100668
32. AQP3 protein expression is regulated by cAMP-PKA-CREB signal pathway. PMID: 25961543
33. The results suggest that morphine increases the AQP3 expression level in the colon, which promotes water absorption from the luminal side to the vascular side and causes constipation. PMID: 25766885
34. Report down-regulation of aquaporin3 expression by lipopolysaccharide via p38/c-Jun N-terminal kinase signalling pathway in HT-29 human colon epithelial cells. PMID: 25914463
35. AQP-3 expression is increased in the burn wound following injury. PMID: 25603981
36. Oleic acid-induced hepatic steatosis in HepG2 cells is associated with the coordinated regulation of aquaporin 3 and aquaporin 9 via activation of p38 signaling PMID: 25105540
37. There is a correlation between AQP3 protein expression and tumour stage and grade in urothelial cancer, with AQP3 expression being reduced or lost in tumours of higher grade and stage. PMID: 24022233
38. AQP3 induces ERK1/2 activation, thereby increasing MMP3 expression and secretion, which in turn promotes prostate cancer cell motility and invasion. PMID: 25515250
39. The opening of ClC-3 transports Cl(-) across the cell membrane and then drives the efflux of water through AQP-3 channels and ion channels; AQP-3 may interact with ClC-3 in order to regulate the effluxes of chloride and water. PMID: 25450461
40. AQP3 expression in tumor tissue may be considered as a potential prognostic marker in patients with HER2-over-expressing EBC after curative surgery. PMID: 25964557
41. results provide a mechanism by which AQP3 is upregulated, as well as highlight the importance of miR-874 in gastric cancer development and progression. PMID: 23800944
42. Resveratrol inhibited NHEK proliferation by downregulating the expression of AQP3 in an SIRT1/ARNT/ERK dependent fashion. PMID: 24726500
43. Investigated both AQP3 expression in the skin of an experimental burn model. Observations suggest that dermal AQP3 gene expression was increased to maintain water homeostasis in response to dehydration from burn. PMID: 24508472
44. We conclude that water fluxes accompanying CFTR activity are linked to AQP3 but not to a cAMP-stimulated aqueous pore in the CFTR protein PMID: 24338365
45. AQP3 promotes epithelial-mesenchymal transition in human cases of gastric adenocarcinoma. PMID: 24887009
46. analysis of the molecular link between the circadian clock and AQP3 function in mouse dorsal skin and HaCaT cells PMID: 24418925
47. AQP3-Notch1 axis may provide insight into epidermal homeostasis control. PMID: 24260356
48. Our data suggest for the first time that the aberrant expression of AQP3 and AQP5 proteins may be strongly related to tumor progression and prognosis in patients with hepatocellular carcinoma PMID: 24224160
49. AQP3-EGFP diffusion is altered upon increased cAMP, which may correspond to basolateral adaptations in response to the increased apical water readsorption. PMID: 24452376
50. High expression of both AQP3 and AQP5, not each alone, is an independent poor prognostic factor in ESCC patients. PMID: 23797770

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Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.

MIP/aquaporin (TC 1.A.8) family

Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level.

HGNC: 636

OMIM: 600170

KEGG: hsa:360

STRING: 9606.ENSP00000297991

UniGene: Hs.234642