Human Bone morphogenetic protein 7,BMP-7 ELISA Kit

Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor. Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors.

1. Study results indicated that BMP7 serves a key function in regulating the progression of small-cell lung cancer. PMID: 30015928
2. in this study, the influence of IGF-1 and BMP-7 in different concentrations on the osteogenic differentiation of two human MSC-subtypes, isolated from reaming debris (RMSC) and iliac crest bone marrow (BMSC) has been assessed PMID: 29874864
3. BMP7 contributes to epithelial-to-mesenchymal transition-like responses and plays a role equivalent to TGF-β in the course of corneal wound healing. PMID: 29747422
4. On the contrary, BMP7 specific antibody inhibits the HNK-induced activation of p53 in colon cancer cells and partly decreases the total level of p53. Our findings suggested that HNK may be a promising anticancer drug for CRC; activation of p53 plays an important role in the anticancer activity of HNK, which may be initialized partly by the HNK-induced upregulation of BMP7. PMID: 28731124
5. All isoforms of type I and type II BMP receptors were expressed in both Ca9-22 and HSC3 cells and BMP7 stimulation resulted in the phosphorylation of Smad1/5/8 in both cell lines PMID: 28812969
6. the results of the present study indicate that BMP7 may inhibit excessive scar formation via activation of the BMP7/Smad1/5/8 signaling pathway. PMID: 28627680
7. BMP7, in particular combined with MSC, seems to have a favourable application also in periodontal regeneration. PMID: 28735626
8. Implantation of morphogenetic protein-7 (BMP-7) gene activated fat tissue fragments can elicit regeneration of large bone defects in rats and could become a clinically expeditious strategy for in vivo bone tissue engineering. PMID: 27373764
9. the present results showed that OP-1 might serve as a biochemical parameter for determining disease severity in primary knee Osteoarthritis (OA). Further studies with larger sample size need to be carried out to confirm OP-1 as a marker of disease status. Studies are required to be done to examine the genetic and lifestyle factors that may contribute to the development of knee OA PMID: 28474632
10. BMP7-Based Functionalized Self-Assembling Peptides Protect Nucleus Pulposus-Derived Stem Cells From Apoptosis In Vitro PMID: 27582519
11. results showed that the expression of cartilage-associated markers in ESC-MSCs induced by the TGFbeta1 and BMP7 combination was increased compared to induction with TGFbeta1 alone. The TGFbeta1 and BMP7 combination upregulated the expression of TGFbeta receptor and the production of endogenous TGFbetas compared to TGFbeta1 induction. PMID: 27292615
12. Overexpression of truncated ALK5 in a B-cell line counteracted BMP-7-induced apoptosis, whereas overexpression of truncated ALK4 had no effect. PMID: 28489883
13. study suggests that the common genetic polymorphisms of BMP7 gene are not major contributors to variations in Bone Mineral Density or osteoporotic fracture in postmenopausal Chinese women. PMID: 27264311
14. Patients with hereditary pulmonary arterial hypertension had significantly higher BMP7 concentrations than patients with idiopathic pulmonary arterial hypertension and control subjects. PMID: 27001265
15. Expression of bone morphogenetic protein 7 ligand was significantly increased in patients with abnormal uterine bleeding. Study demonstrates that bone morphogenetic protein 7 is a promising target for future investigation and pharmacologic treatment of abnormal uterine bleeding. PMID: 28142396
16. BMP-7 directly upregulates adhesion and migration of human monocytic cells via activation of beta 2 integrins, Akt, and FAK. PMID: 27669124
17. results showed that stimulation by BMP-7 leads to an increased osteogenic potential of Mesenchymal stem cells. PMID: 28009419
18. The disequilibrium between BMP-7 and TGF-beta signals plays a relevant role in the LV remodelling response to haemodynamic stress in aortic stenosis patients with left ventricular hypertrophy/dysfunction. PMID: 27068510
19. BMP7 may partly mediate the antiproliferative effect of oridonin by activating p38 MAPK in colon cancer cells. PMID: 26986967
20. Data show that interaction of fibrillin-1 with the bone morphogenetic protein 7 (BMP-7) complex results in a conformational change. PMID: 27059954
21. the role of BMP-7 and its downstream signals in the neuroprotective effects of oxygen-glucose deprivation preconditioning PMID: 26385023
22. miR-137/BMP7 axis could contribute to the progression of non-small cell lung cancer. PMID: 26617798
23. Inhibition of BMP7 expression mediated by KDM5C promotes neoplasm invasion in hepatocellular carcinoma cells. PMID: 26503415
24. Adenovirus-mediated FoxC2 expression enhances BMP7-facilitated anabolism in nucleus pulposus cells of the intervertebral discs. PMID: 26824865
25. ANGPTL4 might promote metastasis and might inhibit apoptosis of colorectal cancer cells by up-regulation of BMP7. PMID: 26417691
26. MiR-22 promotes the development of liver cirrhosis through BMP7 suppression. PMID: 26112332
27. Transfection of HOXA13 in HKCs could inhibit the degree of EMT induced by albumin-overload, possibly by increasing BMP-7 expression. PMID: 26695677
28. rs6127973 may be a risk factor of being Nonsyndromic orofacial clefts and confirmed the role of BMP7 gene in orofacial deformity from Western Han Chinese PMID: 25662552
29. OP-1 levels detected by a polyclonal antibody were found to be much higher than the reference range and correlated positively with the severity of osteoarthritis PMID: 25091889
30. Exposure of adipogenic stem cells to BMP7 promoted gene expression signatures of brown adipocytes. PMID: 25534037
31. BMP-7 improves proliferation and hematopoietic reconstitution potential of ex vivo expanded cord blood-derived CD34(+). cells.( PMID: 25192984
32. hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype PMID: 25716319
33. Bone morphogenetic protein 7 increased vascular endothelial growth factor-a expression in human granulosa cells and VEGF receptor expression in endothelial cells to stimulate angiogenesis. PMID: 24023033
34. Study highlights the potential importance of RGMb in propagating pro-angiogenic effects of HGF and BMP-7. PMID: 24970050
35. BMP-7 may play anti-inflammatory and anti-fibrogenic roles in the pathogenesis of chronic hepatitis B infection. PMID: 24820464
36. BMP-7 inhibits TGF-beta-induced cholangiocarcinoma cell migration through inhibition of TGF-beta-mediated Twist and N-cadherin expression PMID: 24969562
37. BMP-7 represses albumin-induced chemokine synthesis in kidney tubular epithelial cells through destabilization of NF-kappaB-inducing kinase. PMID: 24418819
38. BMP7 expression correlates with secondary drug resistance in mantle cell lymphoma. PMID: 24069261
39. Expression and purification of recombinant human bone morphogenetic protein-7 in Escherichia coli. PMID: 24117149
40. These results suggested an association between a BMP7 single nucleotide polymorphism and selective serotonin reuptake inhibitors treatment response. PMID: 23697978
41. These findings indicate that BMP-7 mediates ischemic preconditioning -induced tolerance to cerebral ischemia/reperfusion, probably through inhibition of apoptosis. PMID: 24184479
42. BMP7 induces Langerhans cell differentiation and proliferation by activating the BMP type-I receptor ALK3 in the absence of canonical TGF-beta1-ALK5 signaling. PMID: 24190429
43. summarize recent knowledge of BMP-7 function and discuss attempts to use this cytokine as a drug to reverse TGF-beta-induced fibrogenesis PMID: 23747893
44. Exogenous BMP-7 significantly decreased the degree of hepatic fibrosis in both the acute and chronic stages of hepato-schistosomiasis, and the regulatory mechanism may involve the TGF-beta/Smad signaling pathway. PMID: 23539268
45. The anti-fibrogenic mechanism of rhBMP-7 in the rat liver fibrosis was depended on the reduction of TGF-b1 overexpression and the inhibition of TGF-b1 triggered intracellular signalling in hepatic cells. PMID: 23471555
46. Nucleus pulposus cells expressing hBMP7 can prevent the degeneration of allogenic intervertebral disc degeneration in a canine transplantation model. PMID: 23580474
47. BMP7 modulates the expression of E-cadherin and MMP-9, and by which mechanism it may regulate cell migration and metastasis of esophageal squamous cell carcinoma. PMID: 23504348
48. A novel human bone morphogenetic protein-7 variant with an enriched heparin-binding site PMID: 23888776
49. There is efficient and reproducible induction of SZP/lubricin accumulation by TGF-beta1 and BMP-7 in skeletal muscle-derived mesenchymal stem cells. PMID: 22490392
50. monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O and SMAD6 cooperated in the regulation of BMP7-induced adipogenesis PMID: 23455153

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Secreted.

TGF-beta family

Expressed in the kidney and bladder. Lower levels seen in the brain.

HGNC: 1074

OMIM: 112267

KEGG: hsa:655

STRING: 9606.ENSP00000379204

UniGene: Hs.473163