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  4. Human C-C motif chemokine 16(CCL16) ELISA kit

Human C-C motif chemokine 16(CCL16) ELISA kit

  • 中文名称：
    人CC趋化因子16(CCL16)酶联免疫试剂盒
  • 货号：
    CSB-EL004779HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：
        CCL16蛋白是一种趋化因子，属于C-C趋化因子家族，也被称为LMR1。它主要由单核细胞、巨噬细胞、树突状细胞等免疫细胞分泌，并且能够吸引嗜酸性粒细胞和单核细胞进入炎症部位。
        CCL16蛋白的生物学作用主要是通过结合其相应的受体CCR1、CCR2和CCR5来实现。这些受体广泛分布于免疫细胞表面，如嗜酸性粒细胞、巨噬细胞、树突状细胞等，参与炎症、免疫调节、组织修复等过程。
        CCL16蛋白的过度表达与多种疾病的发生和发展有关，如哮喘、慢性阻塞性肺疾病、关节炎、神经退行性疾病等。因此，CCL16蛋白成为这些疾病的潜在治疗靶点。一些抑制CCL16/CCR受体信号通路的药物已经在研发过程中，有望成为治疗相关疾病的新型治疗药物。对其生物学作用的深入研究有助于发掘其在疾病治疗方面的潜在应用价值。
        j9九游会登录入口首页生物所提供的Human C-C motif chemokine 16(CCL16) ELISA kit属于ELISA检测试剂盒，采用双抗夹心法定量检测人血清、血浆、组织匀浆样本中的CCL16，其灵敏度为9.77 pg/mL，检测范围为39.06 pg/mL-2500 pg/mL。
     
  • 别名：
    C-C motif chemokine 16 ELISA Kit; CCL16 ELISA Kit; CCL16_HUMAN ELISA Kit; Chemokine (C-C motif) ligand 16 ELISA Kit; Chemokine CC-4 ELISA Kit; Chemokine LEC ELISA Kit; CKb12 ELISA Kit; HCC-4 ELISA Kit; HCC4 ELISA Kit; IL-10-inducible chemokine ELISA Kit; IL10 inducible chemokine ELISA Kit; IL10 inducible chemokine ELISA Kit; ILINCK ELISA Kit; LCC-1 ELISA Kit; LCC1 ELISA Kit; Liver CC chemokine 1 precursor ELISA Kit; Liver expressed chemokine ELISA Kit; Liver-expressed chemokine ELISA Kit; LMC ELISA Kit; Lymphocyte and monocyte chemoattractant ELISA Kit; Monotactin 1 ELISA Kit; Monotactin-1 ELISA Kit; MTN-1 ELISA Kit; Mtn1 ELISA Kit; NCC-4 ELISA Kit; NCC4 ELISA Kit; New CC chemokine 4 ELISA Kit; SCYA16 ELISA Kit; SCYL4 ELISA Kit; Small inducible cytokine A16 precursor ELISA Kit; Small inducible cytokine A16 precursor ELISA Kit; Small inducible cytokine subfamily A (Cys Cys) member 16 ELISA Kit; Small-inducible cytokine A16 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    39.06 pg/mL-2500 pg/mL
  • 灵敏度：
    9.77 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
        CCL16（也称为HCC-4）是一种由多种细胞产生的蛋白质，如巨噬细胞和淋巴细胞。它是一种趋化因子，可以吸引单核细胞、树突状细胞等炎症相关细胞的迁移。研究表明，CCL16参与了许多疾病的发生和发展，如肿瘤、类风湿性关节炎、自身免疫性疾病等。
     
  • 功能：
    Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
  • 基因功能参考文献：
    1. Overexpression of miR-1247 may alleviate LPS-induced A549 cell injury through targeting CCL16. PMID: 29768218
    2. Single nucleotide polymorphism (SNPs) located in and around the C-C motif chemokine ligand 16 (CCL16) gene are associated with CCL16 protein levels in blood plasma, and rs80329614 is the SNP most strongly associated with CCL16 protein levels in plasma. PMID: 27357396
    3. High umbilical artery CCL16 is prominently detected in preterm preeclamptic pregnancies with severe growth restriction. PMID: 22857868
    4. Data show that CCL-16 gene expression was upregulated by 7.46-fold in IBS patients when compared with controls and suggest a subclinical inflammatory component underlying IBS. PMID: 21951809
    5. Low umbilical cord blood chemokine CCL16 associates with spontaneous preterm birth PMID: 21288736
    6. Recombinant CCL16 significantly enhances the effector and the antigen-presenting function of macrophages and augments T cell lytic activity. PMID: 14525962
    7. An adenoviral vector encoding human CCL16 injected into mice with pre-established mammary carcinoma induces strong antitumor response; when given before surgical excision of primary lesions, the treatment prevents metastatic spread and cures 63% of mice. PMID: 15034014
    8. CCL16 induced efficient migratory responses in human and mouse eosinophils. CCL16 is a novel functional ligand for H4 and may have a role in trafficking of eosinophils. PMID: 15265943
    9. CC chemokine-4 (HCC-4)/CCL16 transduces signals differently from other CCR1-dependent chemokines and may play different roles in the immune response. PMID: 16226254
    10. Elevated concentrations in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia PMID: 19494526

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 组织特异性：
    Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.
  • 数据库链接：

    HGNC: 10614

    OMIM: 601394

    KEGG: hsa:6360

    STRING: 9606.ENSP00000293275

    UniGene: Hs.10458