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  4. CCL16 Antibody

CCL16 Antibody

  • 货号：
    CSB-PA169235
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human Lymphoma tissue using CSB-PA169235(CCL16 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA169235(CCL16 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane: HepG2 cells, Primary antibody: CSB-PA169235(CCL16 Antibody) at dilution 1/760, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds
  • 其他：

产品详情

  • Uniprot No.：
    O15467
  • 基因名：
  • 别名：
    C-C motif chemokine 16 antibody; CCL16 antibody; CCL16_HUMAN antibody; Chemokine (C-C motif) ligand 16 antibody; Chemokine CC-4 antibody; Chemokine LEC antibody; CKb12 antibody; HCC-4 antibody; HCC4 antibody; IL-10-inducible chemokine antibody; IL10 inducible chemokine antibody; IL10 inducible chemokine antibody; ILINCK antibody; LCC-1 antibody; LCC1 antibody; Liver CC chemokine 1 precursor antibody; Liver expressed chemokine antibody; Liver-expressed chemokine antibody; LMC antibody; Lymphocyte and monocyte chemoattractant antibody; Monotactin 1 antibody; Monotactin-1 antibody; MTN-1 antibody; Mtn1 antibody; NCC-4 antibody; NCC4 antibody; New CC chemokine 4 antibody; SCYA16 antibody; SCYL4 antibody; Small inducible cytokine A16 precursor antibody; Small inducible cytokine A16 precursor antibody; Small inducible cytokine subfamily A (Cys Cys) member 16 antibody; Small-inducible cytokine A16 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human CCL16
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
  • 基因功能参考文献：
    1. Overexpression of miR-1247 may alleviate LPS-induced A549 cell injury through targeting CCL16. PMID: 29768218
    2. Single nucleotide polymorphism (SNPs) located in and around the C-C motif chemokine ligand 16 (CCL16) gene are associated with CCL16 protein levels in blood plasma, and rs80329614 is the SNP most strongly associated with CCL16 protein levels in plasma. PMID: 27357396
    3. High umbilical artery CCL16 is prominently detected in preterm preeclamptic pregnancies with severe growth restriction. PMID: 22857868
    4. Data show that CCL-16 gene expression was upregulated by 7.46-fold in IBS patients when compared with controls and suggest a subclinical inflammatory component underlying IBS. PMID: 21951809
    5. Low umbilical cord blood chemokine CCL16 associates with spontaneous preterm birth PMID: 21288736
    6. Recombinant CCL16 significantly enhances the effector and the antigen-presenting function of macrophages and augments T cell lytic activity. PMID: 14525962
    7. An adenoviral vector encoding human CCL16 injected into mice with pre-established mammary carcinoma induces strong antitumor response; when given before surgical excision of primary lesions, the treatment prevents metastatic spread and cures 63% of mice. PMID: 15034014
    8. CCL16 induced efficient migratory responses in human and mouse eosinophils. CCL16 is a novel functional ligand for H4 and may have a role in trafficking of eosinophils. PMID: 15265943
    9. CC chemokine-4 (HCC-4)/CCL16 transduces signals differently from other CCR1-dependent chemokines and may play different roles in the immune response. PMID: 16226254
    10. Elevated concentrations in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia PMID: 19494526

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 组织特异性：
    Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.
  • 数据库链接：

    HGNC: 10614

    OMIM: 601394

    KEGG: hsa:6360

    STRING: 9606.ENSP00000293275

    UniGene: Hs.10458