Human C-type lectin domain family 7 member A(CLEC7A) ELISA kit

Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans.

1. The invertebrate tropomyosin presented in the context of impaired dectin-1 function, as observed in allergic individuals, leads to unrestrained IL-33 secretion and skewing of immune responses toward type 2 immunity. PMID: 29475849
2. Dectin-1 receptor blockage decreased the IL-12, IL-17, IL-10 and TNF-alpha levels indicating the participation of such receptor in the induction of these cytokines. PMID: 29110339
3. Dectin-1 is expressed on mDCs and is down-regulated after contact with A. fumigatus, indicating that mDCs recognize A. fumigatus via this receptor. Blocking of Dectin-1, followed by stimulation with depleted zymosan diminished the up-regulation of the T-cell co-stimulatory molecules CD40, CD80, HLA-DR and CCR7 on mDCs and led to decreased release of the cytokines TNF-alpha, IL-8, IL-1beta and IL-10. PMID: 28873980
4. this study shows that Dectin-1 is essential for IL-1beta production through JNK activation and apoptosis in Aspergillus fumigatus keratitis PMID: 28926773
5. high tumoral dectin-1 expression was an independent predictor of adverse clinical outcome in ccRCC patients. This molecule and established nomograms might help clinicians in future decision making and therapeutic developments PMID: 27600310
6. Dectin-1 may have therapeutic implications as a biomarker for metabolic dysregulation in humans. PMID: 28614714
7. theses data suggest miR-146a may play the potent negative feedback regulator in inflammatory response following Dectin-1 stimulation PMID: 28454101
8. These results suggest that the intracellular domain, not ligand-binding domain, of Dectin-1 determines the species-specific ligand profile. PMID: 28848046
9. Unique cytokine secretion and varying expression levels of n Dectin-1 isoforms on monocyte-derived cells may indicate distinct isoform usage as a cell type-specific mechanism of regulating anti-fungal immunity. PMID: 28303575
10. Dectin 1 is highly expressed on macrophages in pancreatic ductal adenocarcinoma. PMID: 28394331
11. Dectin-1-mediated activation of the Syk, MAPKs, PI3K and NF-kappaB signaling pathways contributes to F. proliferatum-stimulated CXCL-8 release from BEAS-2B cells and provides an important basis for developing novel therapeutic strategies in clinical allergy. PMID: 28335387
12. this study shows that curdlan inhibits tumor growth via activating dendritic cells through dectin-1 signaling PMID: 27449326
13. Dectin-1 is essential for efficient immune response against Mycobacteria. PMID: 26709456
14. dectin-1 has a role in glycyrrhetinic acid inhibition of contact hypersensitivity induced by trichophytin PMID: 26739065
15. study represents the first analysis demonstrating that harbouring polymorphisms of Dectin-1 (rs7309123) or TLR2 (rs5743708) represents an independent risk factor of developing IFD in patients with AML undergoing induction chemotherapy. PMID: 26963509
16. Our data suggest that the genetic diversity of CLEC7A gene influences the autism spectrum disorders (ASD) phenotype by behaving as a disease specifier and imply that the genetic control of innate immune response could determine the ASD phenotype. PMID: 26352598
17. this study provides novel and opposing functions of hDectin-1 expressed on the two major human DC subsets, pDCs and mDCs PMID: 26123355
18. The result of this study suggests that there is no correlation between Dectin-1 Y238X Gene polymorphism and RVVC. PMID: 25008994
19. This study demonstrated that Toll-Like Receptors and Dectin-1, a C-Type Lectin Receptor, Trigger Divergent Functions in CNS Macrophages. PMID: 26156997
20. Data indicate that Candida albicans beta-Glucan induces high IL-1 receptor antagonist (IL-1Ra) levels, independently from Dectin-1/complement receptor 3 (CR3). PMID: 25461401
21. The analysis of Dectin-1 gene polymorphisms showed no significant association with fungal keratitis in the northern Han Chinese population. PMID: 25883525
22. Dectin-1 expressed on human pulmonary epithelial cells has a considerable impact on the Nontypeable Haemophilus influenzae triggered immune response. PMID: 25161190
23. The superoxide induction with whole glucan particle was concluded to be Dectin-1-mediated and required Src family kinases, phosphatidylinositol-3 kinase and protein kinase B/Akt. PMID: 24440830
24. IECs may respond to beta-glucans by the secretion of pro-inflammatory chemokines in a Dectin-1- and Syk-dependent pathway PMID: 25251945
25. The unconventional protein secretion triggered by the dectin-1 pathway is dependent on inflammasome activity and an active autophagic process. PMID: 24808366
26. Induction and activation of human Th17 by targeting antigens to dendritic cells via dectin-1. PMID: 24835401
27. this study investigated the role of dectin-1 expressed by keratinocytes in wound healing PMID: 24721111
28. dectin-1 expression in conjunctival epithelial cells (CECs) was demonstrated, and expression of both dectin-1 and BAFF in CECs is thought to be involved in pathologic aggravation of allergic inflammatory in patients with vernal keratoconjuctivitis PMID: 24864436
29. Levels of expression of C-type lectin maybe associated with the pathogenesis of otitis media with effusion. PMID: 24094722
30. we found that secretory IgA is taken up by M cells via the Dectin-1 receptor, with the possible involvement of Siglec-5 acting as a co-receptor. PMID: 24068891
31. Melatonin synthesis in human colostrum mononuclear cells enhances dectin-1-mediated phagocytosis by mononuclear cells. PMID: 23745599
32. Vimentin is an endogenous, activating ligand for Dectin-1. Its presence in areas of artery wall inflammation and O production suggests that vimentin activates Dectin-1 and contributes to lipid oxidation and cholesterol accumulation in atherosclerosis. PMID: 23674515
33. interaction of Dectin-1 with TLR2 seemed to require that both receptors are from the same species PMID: 23787127
34. Results suggest that dectin-1 may play a role in the development of nasal polyps, and may participate in the inflammatory reaction in nasal polyps. PMID: 23332664
35. Expression and function of dectin-1 is defective in monocytes from patients with systemic lupus erythematosus and rheumatoid arthritis. PMID: 23097038
36. beta-glucan primes the response to components of human microbiota through the dectin-1 and noncanonical Raf-1 kinase pathway. PMID: 23475217
37. These data demonstrate that MBL has an ability to mediate the opsonophagocytosis of Candida albicans by human neutrophils independent of complement activation, which is coupled with intracellular Dectin-1-triggered ROS production PMID: 23239982
38. Expressions of TLR2, TLR4 and dectin-1 increased in HaCaT cells in response to Trichophyton rubrum exposure. PMID: 21515468
39. Antibody constant region peptides can display immunomodulatory activity through activation of the Dectin-1 signalling pathway PMID: 22952831
40. Dectin-1 contributes to the Aspergillus fumigatus-induced chemokine synthesis in human bronchial epithelial cells. PMID: 22562430
41. Mycobacterium abscessus activates the NLRP3 inflammasome via dectin-1/Syk-dependent signaling and the cytoplasmic scaffold protein p62/SQSTM1 in human macrophages. PMID: 21876553
42. Dectin-1 and DC-SIGN polymorphisms are associated with invasive pulmonary Aspergillosis infection PMID: 22384201
43. identified a polymorphism in the gene for Dectin-1 (CLEC7A) that is strongly linked to a severe form of ulcerative colitis PMID: 22674328
44. dectin-1 acted as an extracellular sensor for pathogens that induced both IL-1beta production and maturation through a noncanonical caspase-8-dependent inflammasome for protective immunity PMID: 22267217
45. TLR2 and Dectin-1 were expressed by endothelial cells in response to Aspergillus fumigatus stimulation. PMID: 21426724
46. Yeast-derived beta-glucan lacks cytotoxic effects towards B-lymphoma cells but up-regulation of CD86 suggests maturation of the cells via dectin-1 by the carbohydrate PMID: 22199280
47. We demonstrate that heterozygosity for the Y238X DECTIN-1 polymorphism in HIV-infected patients predisposes to bacterial infections, and in particular to pneumonia. PMID: 21985303
48. genetic variation in DECTIN-1 was not associated with susceptibility to candidemia. PMID: 21881131
49. results define the dectin-1/inflammasome pathway as the mechanism that enables the host immune system to mount a protective Th17 response and distinguish between colonization and tissue invasion by Candida albicans PMID: 21531876
50. Dectin-1, a pattern recognition receptor involved in antifungal immunity, polymorphisms in the gene may play a role in human disease (Review) PMID: 20700596

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Candidiasis, familial, 4 (CANDF4)

Cell membrane; Single-pass type II membrane protein.; [Isoform 5]: Cytoplasm.; [Isoform 6]: Cytoplasm.; [Isoform 7]: Cytoplasm.

Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.

HGNC: 14558

OMIM: 606264

KEGG: hsa:64581

STRING: 9606.ENSP00000302569

UniGene: Hs.143929