Human Fibrinogen alpha chain (FGA) ELISA kit

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

1. this study shows that hypofibrinogenaemia associated with novel Aalpha126Val-->Asp mutation in the fibrinogen coiled coil PMID: 28816342
2. All the exons and exon-intron boundaries of fibrinogen genes (FGA, FGB and FGG) were analysed by direct DNA sequencing PMID: 29748775
3. Taken together, an increased pretreatment plasma fibrinogen level was related to worse survival in digestive system tumors, indicating that it could be a useful prognostic marker in these types of tumors. PMID: 29874984
4. The risk of early pregnancy loss was significantly higher in women with homozygous or heterozygous FGA: p.Thr331Ala polymorphism than in women with FGA: p.Thr331 (Odds ratio: 8.84, P < .05). PMID: 27099386
5. Data defined the mutational burden of the fibrinogen FGA, FGB, and FGG genes, and estimated the prevalence of inherited fibrinogen disorders through a systematic analysis of exome/genome data. PMID: 29240685
6. CD47 expression is decreased on the surface of erythrocytes in obese subjects. These changes in CD47 expression on the erythrocytes surface may be an adaptive response to hyperfibrinogenemia associated with obesity. PMID: 25914268
7. Fibrinogen A alpha arginine-glycine-aspartate sequence (residues 95-97) is essential for binding to its erythrocyte receptor. PMID: 29662311
8. Binding of human fibrinogen to MRP enhances Streptococcus suis survival in host blood in a alphaXbeta2 integrin-dependent manner. PMID: 27231021
9. High fibrinogen level is associated with Type-2 diabetes and diabetic vascular disease. PMID: 28119309
10. The heterozygous AalphaArg16His and gammaAsp185Asn identified in the study probably underlie the dysfibrinogenemia in this pedigree, with the latter being identified for the first time. PMID: 28425010
11. Preoperative fibrinogen levels appeared as an independent mortality risk factor in non-metastatic colorectal cancer patients with normal GPS scores PMID: 28269756
12. evidence that VLITL confers amyloidogenic properties to Aalpha-chain frameshift variants, yielding a previously unknown molecular basis for the pathogenesis of Aalpha-chain amyloidosis PMID: 29089309
13. We used mass spectrometry of plasma from trauma patients to find that fibrinogen Aalpha-C domain methionine sulfoxide content was selectively-increased in patients with coagulopathy vs. those without coagulopathy. This evidence supports a novel linkage between oxidative stress, coagulopathy, and bleeding after injury PMID: 27105953
14. Using a quantum chemical approach method, it has been established that mutations in MMP-10 and FGA proteins led to substantial energetic modifications suggesting an impact on their functions and/or stability in the recurrent pregnancy loss patients. PMID: 29016666
15. Data indicate that repeated measurement after five hours showed a statistical significant difference for the fractional synthesis rate of fibrinogen but not for albumin. PMID: 28350862
16. Data indicate only the highest concentration of apixaban was capable to significantly reduce thrombus formation, fibrin association and platelet-aggregate formation. PMID: 28192448
17. Fibrinogen A alpha-chain amyloidosis appears to be an under-recognized disorder in Braga, Portugal, where we found a high frequency of the FGA p.Glu545Val variant PMID: 28359658
18. High fibrinogen expression is associated with pancreatic carcinoma. PMID: 28219450
19. The high preoperative peripheral serum fibrinogen level was related to poor survival in penile cancer patients, suggeting fibrinogen may serve as a powerful predictor of cancer specific survival (CSS) in penile cancer patients. PMID: 27738342
20. Q237 is rapidly crosslinked first by FXIIIa followed by Q366 and Q328. Both (15)NH4Cl and (15)N-GEE could be crosslinked to the three glutamines in alphaC (233-425) with a similar order of reactivity. No glutamine is dependent on another to react first. Moreover, the remaining two glutamines of each mutant were both still reactive. These glutamines play distinct roles in fibrin crosslinking and clot architecture. PMID: 26951791
21. The molecular characterization of two novel afibrinogenemic mutations in the fibrinogen A alpha and fibrinogen B beta chain establishes the importance of the A alpha and B beta C-terminal region for normal fibrinogen assembly and secretion. PMID: 27164460
22. This meta-analysis results did not show significant associations between the polymorphisms in FGA and Ischemic stroke. PMID: 27266621
23. there was a relatively high frequency of pregnancy loss in the setting of the FGA Thr312Ala polymorphism. PMID: 26139837
24. Fibrinogen was significantly increased in pediatric patients with complicated appendicitis compared to patients with uncomplicated appendicitis or non-specific abdominal pain. PMID: 27760719
25. No association between three single nucleotide polymorphisms in the fibrinogen alpha gene and schizophrenia. PMID: 28203040
26. Fibrinogen Shanghai results in N-terminal truncation of Aalpha chain, which does not interfere with synthesis, assembly or secretion of fibrinogen, but compromises fibrin polymerization and clot formation. PMID: 27555433
27. We found a mutation that consists of a R458C substitution on the fibrinogen alpha chain gene confirmed in 13 new familial subjects that causes a rare subtype of dysfibrinogenemia characterized by venous thromboembolic events PMID: 26581183
28. Fibrinogen Nijmegen, a mutation at the same position, is causative for thrombosis, whereas fibrinogen Innsbruck appears to lead to a bleeding tendency, illustrating that even mutations at the same position can cause contrary symptoms. PMID: 26540126
29. Neutrophilic asthma patients and eosinophilic asthma patients had increased fibrinogen compared to controls. PMID: 27044366
30. To novel fibrinogen mutations have been identified (Aa17GlyalphaCys and Aa381SeralphaPhe) that cosegregate with dysfibrinogenemia in seven family members of a Chinese pedigree. PMID: 26083984
31. The study reports two novel mutations detected in the FGA and FGB genes in two patients with inherited hypofibrinogenemia. PMID: 25981141
32. Nutrient overload-induced up-regulation of all three fibrinogen component subunits of the coagulation cascade provides a possible mechanism to explain the excess cardiovascular disease mortality observed in non-alcoholic fatty liver disease patients. PMID: 26256740
33. No association between cognition and gene polymorphisms involved in thrombosis and haemostasis PMID: 26228839
34. An analysis of the results obtained in this study and a critical review of previously published data indicate that gene polymorphisms in FGA and FGB are not related to ischemic stroke in children PMID: 25555432
35. Results support the idea that fibrinogen alphaC regions are involved in the thickening of fibrin fibers. PMID: 25393591
36. The study identified a 5.9 kDa C-terminal fragment of the fibrinogen alpha chain as an early serum biomarker of fibrogenic processes in patients with liver disease. PMID: 25275549
37. The Aalpha-Val360 related cross-sectionally to physiologic, radiologic, and symptomatic markers of disease severity of PiZZ alpha1-antitrypsin deficiency. PMID: 25569856
38. Case Report: hepatocytes homozygous for a large FGA deletion can be genetically modified to restore Aalpha-chain protein expression and secrete a functional fibrinogen hexamer. PMID: 25163824
39. High plasma D-dimer, fibrinogen, and platelet levels are associated with epithelial ovarian cancer independently of venous thromboembolism. PMID: 25347092
40. Elevated pre-operative plasma fibrinogen level is associated with aggressive soft-tissue sarcoma. PMID: 24122271
41. Results show that oxidized fibrinogen, instead of serum albumin (HSA), is the key protein for intermolecular dityrosine formation in plasma. PMID: 25280629
42. Plasma fibrinogen is an independent predictor for the severity of coronary artery disease in diabetic patients. PMID: 24803720
43. findings indicate that FGA and SLC6A4 gene interactions may contribute to the phenotypes of ASD rather than the incidence of ASD. PMID: 24192574
44. role in regulation of clot formation and fibrinolysis PMID: 24048413
45. Both crude and multivariable regression analyses show that the FGA Thr312Ala polymorphism is a protective factor in the Polish population under dominant and additive models of inheritance. PMID: 24821635
46. Data indicate that ibrinogen binding to Staphylococcus aureus fibronectin-binding protein A (FnBPA) is sterically regulated by fibronectin binding. PMID: 24627488
47. Stepwise assembly of fibrinogen is assisted by the endoplasmic reticulum ERp57 lectin-chaperone system in a human hepatocyte cell line. PMID: 24040290
48. Studies indicate that in afibrinogenemia and hypofibrinogenemia, most mutations of the FGA, FGB, or FGG fibrinogen encoding genes are null mutations. PMID: 23852822
49. Elevated plasma fibrinogen levels are associated with nonmetastatic colon cancer. PMID: 23612884
50. These results indicate that DPT can modify certain biological functions of fibrin, and thus a another function of this extracellular matrix protein was revealed. PMID: 23877568

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Congenital afibrinogenemia (CAFBN); Amyloidosis 8 (AMYL8); Dysfibrinogenemia, congenital (DYSFIBRIN)

Secreted.

Detected in blood plasma (at protein level).

HGNC: 3661

OMIM: 105200

KEGG: hsa:2243

STRING: 9606.ENSP00000306361

UniGene: Hs.351593