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  4. Human Insulin-like growth factor-binding protein 7 (IGFBP7/MAC25/PSF) ELISA kit

Human Insulin-like growth factor-binding protein 7 (IGFBP7/MAC25/PSF) ELISA kit

  • 中文名称：
    人胰岛素样生长因子结合蛋白7(IGFBP7/MAC25/PSF)酶联免疫试剂盒
  • 货号：
    CSB-E17249h
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：
        细胞外IGF结合蛋白7(Insulin-like growth factor binding protein 7)，也被称为Mac25、PSF或angiomodulin，是一种由肿瘤细胞、平滑肌细胞和内皮细胞等多种细胞产生的分泌型糖蛋白。IGFBP7具有细胞增殖抑制和调节作用，参与多种生物学过程如细胞增殖、分化、凋亡和细胞周期调节。研究表明，在心脏、肝脏、肺、肾脏、肠道、卵巢和前列腺等多种组织中都可检测到IGFBP7的表达。IGFBP7在肿瘤中的表达水平与多种肿瘤的生长、转移、恶性程度及预后密切相关，因此被认为是一个重要的肿瘤标志物。
        j9九游会登录入口首页生物所提供的Human Insulin-like growth factor-binding protein 7 (IGFBP7/MAC25/PSF) ELISA kit属于ELISA检测试剂盒，采用双抗夹心法定量检测人血清、血浆、匀浆样本中的IGFBP7，其灵敏度为19.5 pg/ml，检测范围为78 pg/ml - 5000 pg/ml。
     
  • 别名：
    AGM ELISA Kit; Angiomodulin ELISA Kit; FSTL2 ELISA Kit; IBP-7 ELISA Kit; IBP7 ELISA Kit; IBP7_HUMAN ELISA Kit; IGF binding protein 7 ELISA Kit; IGF-binding protein 7 ELISA Kit; IGFBP rP1 ELISA Kit; IGFBP-7 ELISA Kit; IGFBP-rP1 ELISA Kit; IGFBP7 ELISA Kit; IGFBPRP1 ELISA Kit; Insulin like growth factor binding protein 7 ELISA Kit; Insulin-like growth factor-binding protein 7 ELISA Kit; MAC25 ELISA Kit; MAC25 protein ELISA Kit; PGI2 stimulating factor ELISA Kit; PGI2-stimulating factor ELISA Kit; Prostacyclin stimulating factor ELISA Kit; Prostacyclin-stimulating factor ELISA Kit; PSF ELISA Kit; RAMSVPS ELISA Kit; TAF ELISA Kit; Tumor-derived adhesion factor ELISA Kit
  • 缩写：
    IGFBP7
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, homogenates
  • 检测范围：
    78 pg/ml - 5000 pg/ml
  • 灵敏度：
    19.5 pg/ml
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Signal Transduction
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：

      

  • 线性度：

      

  • 回收率：

      

  • 标准曲线：

      

  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
    IGFBP7 (Insulin-like growth factor binding protein 7)是一种结合胰岛素样生长因子(IGF)的蛋白，与调控细胞生长、凋亡和分化有关。最新研究表明，IGFBP7在多种癌症中表达水平上调，与癌症的进展、转移和预后有关联。此外，IGFBP7还被发现参与心血管疾病、慢性肾脏疾病等疾病的发生和发展。
  • 功能：
    Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
  • 基因功能参考文献：
    1. Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. PMID: 29563502
    2. IGFBP7 upregulation promotes osteogenic differentiation of mesenchymal stem cells via the Wnt/beta-catenin signaling. PMID: 29242275
    3. Low IGFBP7 expression is associated with Gastric Cancer. PMID: 29580038
    4. Reduced RNA editing of IGFBP7 gene is associated with psoriasis. PMID: 29592874
    5. Urine levels of IGFBP7 (and TIMP2) are predictive for acute kidney injury following cardiac surgical procedures. PMID: 28803769
    6. IGFBPrP1 transfection inhibited cell growth, and induced G1 phase arrest and cellular senescence in HEC1A cells while gene silencing presented the adverse functional changes. PMID: 29067463
    7. Serum IGFBP7 levels were raised during acute exacerbation in COPD patients. PMID: 28684903
    8. biomarker for acute kidney injury PMID: 27174659
    9. epithelial cells and leukocytes from the urinary sediment. CONCLUSION: The gene expression pattern of IGFBP7 and TIMP-2 from urinary sediment, which contains desquamated renal tubular epithelial cells, did not correlate with [IGFBP7]x[TIMP-2] protein, indicating that IGFBP7 and TIMP-2 measured in the NephroCheck(R) test originated predominantly from intact but stressed cells of the kidney itself PMID: 29145491
    10. In patients with heart failure with preserved ejection fraction, IGFBP7 may be a novel biomarker of diastolic function and exercise capacity. PMID: 27744089
    11. High IGFBP7 expression is associated with acute kidney injury. PMID: 27342580
    12. NEAT1-associated paraspeckle proteins P54nrb and PSF have been reported as positive regulators of c-Myc translation through interaction with c-Myc IRES PMID: 28288210
    13. Urine [TIMP-2]*[IGFBP7] is a promising candidate for early detection of AKI, especially in ruling-out AKI PMID: 28107490
    14. Meta-analysis indicated that urinary [TIMP-2].[IGFBP7] may be a reliable biomarker for the early detection of acute kidney injury in adults. PMID: 28682920
    15. TIMP-2 is both expressed and secreted preferentially by cells of distal tubule origin, while IGFBP7 is equally expressed across tubule cell types yet preferentially secreted by cells of proximal tubule origin. In human kidney tissue, strong staining of IGFBP7 was seen in the luminal brush-border region of a subset of proximal tubule cells, and TIMP-2 stained intracellularly in distal tubules. PMID: 28003188
    16. loss of IGFBP7 and upregulation of IGF1 activates the FGF4-FGFR1-ETS2 pathway in Tumor-associated endothelial cells (TECs) and converts naive tumor cells to chemoresistant tumor stem-like cells (TSCs), thereby facilitating their invasiveness and progression. PMID: 27989801
    17. Data report that IGFBP7 is a novel target gene of ADAR2 in esophageal squamous cell carcinoma where its RNA is edited and protein stabilized by ADAR2. PMID: 28035363
    18. quantitative urine test is available to assess the risk of developing AKI by measuring the concentrations of two protein biomarkers, TIMP-2 and IGFBP-7 PMID: 26797672
    19. Insulin-like growth factor binding protein 7 (IGFBP7) was proven to be associated with metastatic clinicopathological features and high lymphatic vascular density PMID: 26706909
    20. This process not only provides a remarkable high expression at ~50mg/L and pure glycosylated mammalian rhIGFBP7, also highlights that transient gene expression technology is practical to be used for production PMID: 26474694
    21. data suggest that TGF-beta1 enhances IGFBP7 via Smad2/4 pathways, and that IGFBP7 might be involved in the TGF-beta1-induced tubular injury in DN. PMID: 26974954
    22. This study shows that urinary [TIMP-2]*[IGFBP7] has a good diagnostic performance in predicting adverse outcomes in neonatal and pediatric AKI of heterogeneous etiology. PMID: 26606754
    23. low expression in breast cancer tissue PMID: 26387651
    24. serum IGFBP7 levels are associated with IR and MetS, providing new insight into the mechanism of IR and Mets. IGFBP7 may be a potential interventional target for IR and Mets. PMID: 25984973
    25. IGFBP-7 can alter EMT relative marker genes and suppress cell invasion in A253 cell through AKT/GSK3beta/beta-catenin signaling. PMID: 25880247
    26. IGFBP7 down-regulation is associated with poor prognosis in glioma, and this molecule may represent both a prognostic marker and a potential therapeutic target. PMID: 24743871
    27. Our data indicate that IGFBP7 expression is a marker for a specific methylation pattern in myeloma PMID: 25887188
    28. The low levels of IGFBP7 in high-grade serous ovarian carcinoma are associated with survival rate. PMID: 25886299
    29. Overexpression of IGFBP7 was associated with tumour progression and poor survival in gastric cancer. IGFBP7 may play a role in tumour progression in gastric cancer. PMID: 26043748
    30. we demonstrated that IGFBP-rP1 suppresses EMT and tumor metastasis by repressing TGF-b-mediated EMT through the Smad signaling cascade. PMID: 25789970
    31. IGFBP7 in urine was identified as a reliable marker of cell cycle arrest induction in acute kidney injury. PMID: 23388612
    32. The decline in urinary TIMP-2 and IGFBP7 values was the strongest predictor for renal recovery following cardiac surgery. PMID: 24675717
    33. in contrast to its tumor-suppressor function in epithelial cells, IGFPB7 can promote anchorage-independent growth in malignant mesenchymal cells and in epithelial cells with an EMT phenotype when IGFBP7 is expressed by the tumor cells PMID: 24632618
    34. These results suggest that AGM cooperates with VEGF to induce the aberrant functions of cancer vasculature as a ligand of integrin alpha5beta3. PMID: 24737780
    35. AML patients with high IGFBP7 expression have a better outcome than patients with low IGFBP7 expression, indicating a positive role for IGFBP7 in treatment and outcome of AML. PMID: 24967962
    36. Data indicate that insulin-like growth factor binding protein 7 (IGFBP7) was downregulated in gastric cancer, and its low expression was potentially correlated with increased cell proliferation and could be used to predicate poor prognosis in patients. PMID: 24894674
    37. as urinary marker, discriminated between early and late/non-recovery patients and patients with and without acute kidney injury PMID: 24067438
    38. IGFBP-rP1 contributes to the development of liver fibrosis and may be a novel molecule involved in the progression of hepatic fibrogenesis. PMID: 24373620
    39. High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-beta and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner. PMID: 24427302
    40. These data suggest that IGFBP7 is a critical regulator of memory consolidation and might be used as a biomarker for AD. PMID: 24075854
    41. Methylation of the IGFBP7 promoter was associated with silencing of gene expression and was frequent in Barrett's oesophagus and oesophageal adenocarcinoma PMID: 24357797
    42. Perfomed proteomic analysis on a transgenic mouse model of severe cardiac hypertrophy; compared data to dataset of heart failure found MYH7, IGFBP7, ANXA2, and DESM to be biomarker candidates for heart failure. PMID: 23713052
    43. Report A-to-I editing in the coding sequence of IGFBP7 in cancerous human keratinocytes. PMID: 23543219
    44. hypomethylation of LINE-1 and hypermethylation of SLIT2, MAL and IGFBP7 were frequently detected in NSCLCs and associated with various clinical features. PMID: 23381221
    45. Results indicate that restoration of IGFBP-rP1 to PC-3 cells increases both their radiosensitivity and chemosensitivity. PMID: 23600329
    46. Low expression of IGFBP7 is associated with pancreatic ductal adenocarcinoma. PMID: 22622471
    47. Hyperinsulinemia and high IGFBP-rP1 levels confer altered risks for endometrial carcinoma. PMID: 22544761
    48. Results demonstrate that CpG methylation of IGFBP7 may represent a novel biomarker of prostate cancer and pre-invasive neoplasms PMID: 22906661
    49. editing of IGFBP7 transcripts impacts the protein's susceptibility to proteolytic cleavage, thus providing a means for a cell to modulate its functionality through A-to-I RNA editing PMID: 22750143
    50. Transfection of IGFBP-rP1 or addition of condition medium (CM) from IGFBP-rP1-transfected cells in MCF-7 cells caused induction of a variety of senescent phenotypes. PMID: 22392074

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  • 相关疾病：
    Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS)
  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    HGNC: 5476

    OMIM: 602867

    KEGG: hsa:3490

    STRING: 9606.ENSP00000295666

    UniGene: Hs.479808