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  4. Human Interferon inducible T-cell Chemoattractant,I-TAC ELISA Kit

Human Interferon inducible T-cell Chemoattractant,I-TAC ELISA Kit

  • 中文名称：
    人干扰素诱导T细胞趋化因子(ITAC/CXCL11)酶联免疫试剂盒
  • 货号：
    CSB-E09023h
  • 规格：
    96T/48T
  • 价格：
    ￥3200/￥2500
  • 其他：

产品详情

  • 产品描述：
        趋化因子11（C-X-C motif chemokine ligand 11）也称为I-TAC，可以调节免疫细胞的趋化、增殖和激活。它是一种通过作用于CXCR3受体介导的细胞因子，主要在炎症和免疫反应中发挥作用。
        j9九游会登录入口首页生物所提供的Human Interferon inducible T-cell Chemoattractant,I-TAC ELISA Kit属于ELISA检测试剂盒，采用双抗夹心法定量检测人血清、血浆、组织匀浆样本中的CXCL11，其灵敏度为7.8 pg/mL，检测范围为31.25 pg/mL-2000 pg/mL。
     
  • 别名：
    b R1 ELISA Kit; b-R1 ELISA Kit; Beta-R1 ELISA Kit; betaR1 ELISA Kit; C-X-C motif chemokine 11 ELISA Kit; Chemokine (C-X-C motif) ligand 11 ELISA Kit; Chemokine C-X-C motif ligand 11 ELISA Kit; CXC11 ELISA Kit; CXCL11 ELISA Kit; CXL11_HUMAN ELISA Kit; H174 ELISA Kit; I TAC ELISA Kit; I-TAC ELISA Kit; Interferon gamma inducible protein 9 ELISA Kit; Interferon gamma-inducible protein 9 ELISA Kit; Interferon inducible T cell alpha chemoattractant ELISA Kit; Interferon-inducible T-cell a chemoattractant I-TAC ELISA Kit; Interferon-inducible T-cell alpha chemoattractant ELISA Kit; IP 9 ELISA Kit; IP-9 ELISA Kit; IP9 ELISA Kit; ITAC ELISA Kit; MGC102770 ELISA Kit; SCYB11 ELISA Kit; SCYB9B ELISA Kit; Small inducible cytokine B11 ELISA Kit; Small inducible cytokine subfamily B (Cys-X-Cys) member 11 ELISA Kit; Small inducible cytokine subfamily B (Cys-X-Cys) member 9B ELISA Kit; Small inducible cytokine subfamily B; member 11 ELISA Kit; Small inducible cytokine subfamily B; member 9B ELISA Kit; Small-inducible cytokine B11 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    31.25 pg/mL-2000 pg/mL
  • 灵敏度：
    7.8 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human I-TAC in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:1 Average % 87  
    Range % 81-95  
    1:2 Average % 96  
    Range % 90-105  
    1:4 Average % 97  
    Range % 92-103  
    1:8 Average % 93  
    Range % 86-98  
  • 回收率：
    The recovery of human I-TAC spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 95 83-99  
    EDTA plasma (n=4) 97 92-100  
                 
                 
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected  
    2000 2.650 2.593 2.622 2.522  
    1000 1.704 1.684 1.694 1.594  
    500 0.964 0.982 0.973 0.873  
    250 0.528 0.515 0.522 0.422  
    125 0.330 0.322 0.326 0.226  
    62.5 0.215 0.220 0.218 0.118  
    31.25 0.162 0.169 0.166 0.066  
    0 0.102 0.097 0.100    
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
    CXCL11，也称为I-TAC（干扰素γ诱导蛋白10），是一种由人体细胞产生的细胞因子，主要由激活的T细胞和巨噬细胞产生，能够介导免疫细胞在炎症和免疫应答中的迁移和定向。近年来的研究表明，CXCL11与多种疾病的发生和发展密切相关，如肿瘤、自身免疫性疾病、炎症性疾病等。研究人员正在探索利用CXCL11作为治疗靶点或作为疾病诊断和预测指标的可能性。
  • 功能：
    Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
  • 基因功能参考文献：
    1. V2O5 induction of CXCL8 and CXCL11 chemokines may lead to the appearance and perpetuation of an inflammatory reaction into the dermal tissue. Further studies are required to evaluate dermal integrity and manifestations in subjects occupationally exposed, or living in polluted areas. PMID: 29901202
    2. BK polyomavirus infection can induce CXCL11 gene expression in kidney transplant patients. PMID: 27759557
    3. CXCL11 production in cerebrospinal fluid was found in herpes simplex meningitis, but not in herpes simplex encephalitis. PMID: 28693588
    4. Neuroendocrine-like cells promote the chemotaxis activity of tumor-associated macrophages (TAM) via CXCL10 and CXCL11. PMID: 27034164
    5. High CXCL11 expression is associated with clear-cell renal cell carcinoma. PMID: 26910919
    6. this study shows that melanoma peptides vaccination and intratumoral administration of IFNgamma increases production of CXCL11 in patient tumors PMID: 27522581
    7. Downregulation of CXC chemokine ligand 11 can inhibit tumor angiogenesis, suggesting that anti-CXC chemokine ligand 11 therapy may offer an alternative treatment strategy for TWIST1-positive ovarian cancer PMID: 28488542
    8. CXCL8/11 may promote the disease progression of osteoarthritis (OA), and may also serve as new therapeutic targets for treatment of OA. PMID: 27567247
    9. this study shows that oxidative signaling inhibits T lymphocyte chemotaxis to the inflammatory chemokine CXCL11 PMID: 28363904
    10. The homozygous variant CXCL11 AA genotype (rs6817952) is associated with an increased risk of contact allergy. PMID: 27356947
    11. In contrast to elevated 1st trimester levels of IP-10 previously found in the maternal serum of women who later developed preeclampsia, this study found lower umbilical cord IP-10 and ITAC plasma levels in near-term gestations with established severe preeclampsia. PMID: 25741937
    12. CXCL11 levels are mainly increased in patients with non-alcoholic cirrhosis and high portal pressure. Moreover, levels of CXCL11 might predict long-time survival of cirrhotic patients undergoing TIPS. PMID: 26212075
    13. higher concentration is associated with neutrophils accumulation in the alveolar space of Systemic Lupus Erythematosus patients with pulmonary fibrosis PMID: 26275808
    14. Developmental expression patterns of chemokines CXCL11, CXCL12 and their receptor CXCR7 in testes PMID: 25810367
    15. congruent with the concept that inflammation plays a key role in the pathogenesis of LV dysfunction, MIG, IP10 and I-TAC add diagnostic accuracy over and beyond NT-pro BNP. PMID: 26506526
    16. Resveratrol substantially inhibited the proinflammatory cytokines-induced CXCL11 production while partially blocking nuclear factor-kappaB activation. PMID: 25890876
    17. Common variants of CXCR3 and its ligands CXCL10 and CXCL11 are associated with vascular permeability of dengue infection in peninsular Malaysia. PMID: 25858769
    18. Cyclic stretch significantly induced ESC secretion of CXCL8 and CXCL1 and neutrophil chemotaxis. Stretch also increased MMP-1, MMP-2, and MMP-3 activity, activin A secretion, and activity in ESC. PMID: 25605062
    19. High CXCL11 expression is associated with acute cellular rejection. PMID: 25251331
    20. These findings functionally integrate K17, hnRNP K, and gene expression along with RSK and CXCR3 signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis PMID: 25713416
    21. The homozygosity for the CXCL9 rs10336 (T), CXCL10 rs3921 (G), and CXCL11 rs4619915 (A) alleles is associated with the higher likelihood of significant liver fibrosis in HIV-infected patients coinfected with hepatitis C virus genotype 1. PMID: 25559603
    22. The chemokine CXCL11 is produced by mesenchymal stem cells and interacts with CXCR3. PMID: 24526602
    23. CXCL11 displays antimicrobial activity against E. coli and S. aureus. PMID: 12949249
    24. The expression of MIF mRNA was compared with VEGF mRNA expression and with mRNA expression of other chemokines related to neo-angiogenesis, such as CXCL12, CXCL11, CXCL8 and CXCR4, in human endometrial cancer tissue and normal endometrium. PMID: 23985752
    25. CXCL11 was mildlylavage fluid during diffuse alveolar damage, but not during acute rejection or lymphocytic bronchiolitis. Elevated CXCL11 was associated with increased risk of chronic allograft dysfunction. PMID: 24063316
    26. Our study demonstrates in mixed cryoglobulinemia and hepatitis C vs controls: (i)high serum CXCL9 and CXCL11, significantly associated with the presence of active vasculitis; (ii) a strong relationship between circulating CXCL9 and CXCL11 PMID: 23527708
    27. CXCR3 ligands CXCL10, CXCL9 and CXCL11 were measured in 245 children with opsoclonus-myoclonus syndrome and 81 controls. PMID: 23600831
    28. There was no difference in expression of I-TAC between immune thrombocytopenic purpura patients and healthy controls. PMID: 23158864
    29. Expression of CXCL9, -10, and -11 chemokines and their receptor CXCR3 increases in the aqueous humor of patients with herpetic endotheliitis. PMID: 22367045
    30. This study demonistrated that CXCL11, absent from normal muscle fibers, were induced in DMD myofibers. and up regulattion on blood vessel endothelium of DMD patients. PMID: 23225384
    31. Our study first demonstrates higher serum levels of CXCL11 chemokine in patients with mixed cryoglobulinemia than in hepatitis C virus-positive patients, and in particular in the presence of autoimmune thyroiditis. PMID: 22160826
    32. In chronic graft-vs-host disease, increased levels of the Th1-associated chemokines CXCL9, CXCL10, and CXCL11 led to recruitment of CXCR3+ T cells from the peripheral blood into affected tissues. PMID: 23012327
    33. Elevated BALF concentrations of CXCL11 in systemic sclerosis patients who do not developed lung fibrosis suggest that determination of CXCL11 in BALF could serve as a prognostic factor for pulmonary function decline. PMID: 22691213
    34. CXCL10, CXCL11, CXCL12 and CXCL13 chemokines are biomarkers in serum and cerebrospinal fluid in patients with tick borne encephalitis PMID: 22008312
    35. A strong relationship between circulating IFN-gamma and CXCL11 is shown, supporting the role of a T helper (Th)1 cell immune response in the pathogenesis of mixed cryoglobulinemia and hepatitis C. PMID: 21724697
    36. circulating CXCL11, together with CXCL10, is increased in patients with thyroiditis and hypothyroidism, and is related to CXCL10 levels. PMID: 22168752
    37. Elevated plasma levels of interferon-gamma and Cys-X-Cys chemokine receptor 3-binding chemokine CXCL11 are present in patients with thoracic aortic aneurysms. PMID: 21962843
    38. CXCR3 ligands, CXCL9,10,11, are differentially expressed during chronic liver diseases across different disease stages and aetiologies. PMID: 21645215
    39. We first show that circulating CXCL9 and CXCL11 are increased in patients with thyroiditis and hypothyroidism and are related to each other. PMID: 21470996
    40. involved in microbial-induced intestinal inflammation and Th17 cell development in ulcerative colitis PMID: 21438871
    41. A potent dose-dependent inhibition by PPARalpha-agonists was observed on the cytokines-stimulated secretion of CXCL11 in Graves disease and in primary thyrroid culture. PMID: 20810571
    42. The expression and function of CXCR3 and CXCR7 receptors in cervical carcinoma, rhabdomyosarcoma and glioblastoma cell lines, was evaluated. PMID: 20529825
    43. Studies indicate that CXCR7 is an interceptor for CXCL12 and CXCL11. PMID: 20036838
    44. TNFSF14 enhanced IFN-gamma-induced secretion of CXCL10 and CXCL11 from human gingival fibroblasts. PMID: 19939453
    45. Studies indicate that I-TAC-targeted intervening strategies would have potential application for the alleviation of acute transplant rejection. PMID: 19875106
    46. I-TAC is a highly potent chemoattractant of normal blood CD4 and CD8 T cell transendothelial migration and a major mediator of blood memory T lymphocyte migration to inflammation. PMID: 12055261
    47. The IFN-gamma-inducible T cell alpha-chemoattractant was induced in human brain microvascular endothelial cells and astrocytes only after inflammatory stimuli. PMID: 12162873
    48. These data suggest that IFN-beta acts through PI3K to enhance the transactivation competence of NF-kappa B complexes through phosphorylation of p65 within the TAD of beta-R1. PMID: 12169689
    49. Levels of ITAC/CXCL11 were found elevated in patients with severe transplantation coronary artery disease (TCAD) compared with long-term survivors of transplantation without TCAD and healthy volunteers who had not undergone transplantation PMID: 12695288
    50. increased calpain activity in undifferentiated keratinocytes. inhibited calpain activity in fibroblasts. redifferentiated basal keratinocytes limit fibroblast repopulation of dermis of healed wounds while promoting re-epithelialization. PMID: 12787142

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine alpha (chemokine CxC) family
  • 组织特异性：
    High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.
  • 数据库链接：

    HGNC: 10638

    OMIM: 604852

    KEGG: hsa:6373

    STRING: 9606.ENSP00000306884

    UniGene: Hs.632592