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  4. Human Interleukin-22 receptor subunit alpha-2(IL22RA2) ELISA kit

Human Interleukin-22 receptor subunit alpha-2(IL22RA2) ELISA kit

  • 中文名称：
    人白介素-22受体α-2亚基(IL22RA2)酶联免疫试剂盒
  • 货号：
    CSB-EL011637HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Human IL22RA2 ELISA Kit was designed for the quantitative measurement of Human IL22RA2 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 31.25 pg/mL-2000 pg/mL and the sensitivity is 7.81 pg/mL.

  • 别名：
    IL 22BP ELISA Kit; IL 22RA2 ELISA Kit; IL22RA2 ELISA Kit; Class II cytokine receptor ELISA Kit; CRF2 10 ELISA Kit; CRF2 S1 ELISA Kit; CRF2-10 ELISA Kit; CRF2-S1 ELISA Kit; CRF2X ELISA Kit; Cytokine receptor class II member 10 ELISA Kit; Cytokine receptor class-II member 10 ELISA Kit; Cytokine receptor family 2 member 10 ELISA Kit; Cytokine receptor family type 2 ELISA Kit; Cytokine receptor family type 2 soluble 1 ELISA Kit; I22R2_HUMAN ELISA Kit; IL 22 receptor subunit alpha 2 ELISA Kit; IL 22R alpha 2 ELISA Kit; IL-22 receptor subunit alpha-2 ELISA Kit; IL-22BP ELISA Kit; IL-22R-alpha-2 ELISA Kit; IL-22RA2 ELISA Kit; IL22 RA2 ELISA Kit; IL22BP ELISA Kit; IL22R alpha 2 ELISA Kit; Il22ra2 ELISA Kit; Interleukin 22 binding protein ELISA Kit; Interleukin 22 Receptor alpha 2 ELISA Kit; Interleukin-22 receptor subunit alpha-2 ELISA Kit; Interleukin-22-binding protein ELISA Kit; MGC150509 ELISA Kit; MGC150510 ELISA Kit; soluble 1 ELISA Kit; ZcytoR16 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    31.25 pg/mL-2000 pg/mL
  • 灵敏度：
    7.81 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human IL22RA2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 94
    Range % 87-98
    1:2 Average % 107
    Range % 103-112
    1:4 Average % 91
    Range % 85-97
    1:8 Average % 92
    Range % 88-96
  • 回收率：
    The recovery of human IL22RA2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 102 98-105
    EDTA plasma (n=4) 98 93-104
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    2000 1.927 2.057 1.992 1.889
    1000 1.342 1.460 1.401 1.298
    500 0.922 0.965 0.944 0.841
    250 0.651 0.663 0.657 0.554
    125 0.432 0.412 0.422 0.319
    62.5 0.254 0.269 0.262 0.159
    31.25 0.208 0.201 0.205 0.102
    0 0.104 0.102 0.103 　
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.; Isoform 1 may play a role in establishing and maintaining successful pregnancy.
  • 基因功能参考文献：
    1. expression higher in the epidermal compartment of the skin in comparison with dermis in both healthy skin and psoriasis skin PMID: 27676439
    2. suggest that the human IL-22BP isoforms have distinct spatial and temporal roles and coordinately fine-tune IL-22-dependent STAT3 responses in tissues as a type of rheostat. PMID: 27678220
    3. thia study shows shows that nonaffected skin of psoriasis patients displays lower expression of IL-22BP than skin of healthy controls, and that the strong IL-22 increase in lesional psoriatic skin is accompanied by a moderate induction of IL-22BP PMID: 28356382
    4. The deletion of IFNGR1 causes complete IFN-gammaR1 deficiency. Despite the deletion ending very close to the IL22RA2 gene, it does not appear to affect IL22RA2 transcription. PMID: 26931784
    5. IL-22BP is produced by eosinophils in the gut and blocks IL-22 protective actions in colitis. PMID: 26329427
    6. Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene. PMID: 21041731
    7. The IL-22R and IL-10R2 binding sites are juxtaposed on adjacent IL-22 surfaces contributed mostly by helices A, D, and F and loop AB. PMID: 18675824
    8. Crystallization and preliminary X-ray diffraction results of the IL-22-IL-22 binding protein (IL-22BP) complex are described. PMID: 19193995
    9. Polymorphisms in IL22RA1 are associated with severe CRS. PMID: 19393422

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Type II cytokine receptor family
  • 组织特异性：
    Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placen
  • 数据库链接：

    HGNC: 14901

    OMIM: 606648

    KEGG: hsa:116379

    STRING: 9606.ENSP00000296980

    UniGene: Hs.126891