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  4. Human Interleukin-31 receptor subunit alpha(IL31RA) ELISA kit

Human Interleukin-31 receptor subunit alpha(IL31RA) ELISA kit

  • 中文名称：
    人白介素-31受体α亚基(IL31RA)酶联免疫试剂盒
  • 货号：
    CSB-EL011654HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Human IL31RA ELISA Kit was designed for the quantitative measurement of Human IL31RA protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 6.25 pg/mL-400 pg/mL and the sensitivity is 1.56 pg/mL.

  • 别名：
    Class I cytokine receptor ELISA Kit; CRL 3 ELISA Kit; CRL ELISA Kit; CRL3 ELISA Kit; Cytokine receptor like 3 ELISA Kit; Cytokine receptor-like 3 ELISA Kit; GLM R ELISA Kit; GLM-R ELISA Kit; GLMR ELISA Kit; Gp130 like monocyte receptor ELISA Kit; GP130 like receptor ELISA Kit; Gp130-like monocyte receptor ELISA Kit; Gp130-like receptor ELISA Kit; GPL ELISA Kit; HGLM R ELISA Kit; HGLM-R ELISA Kit; HGLMR ELISA Kit; IL 31 receptor subunit alpha ELISA Kit; IL 31R subunit alpha ELISA Kit; IL 31RA ELISA Kit; IL-31 receptor subunit alpha ELISA Kit; IL-31R subunit alpha ELISA Kit; IL-31R-alpha ELISA Kit; IL-31RA ELISA Kit; IL31 receptor subunit alpha ELISA Kit; IL31R subunit alpha ELISA Kit; IL31R_HUMAN ELISA Kit; IL31RA ELISA Kit; Interleukin 31 receptor A ELISA Kit; interleukin 31 receptor subunit alpha ELISA Kit; Interleukin-31 receptor subunit alpha ELISA Kit; MGC125346 ELISA Kit; PLCA 2 ELISA Kit; PLCA2 ELISA Kit; PRO21384 ELISA Kit; Soluble type I cytokine receptor CRL3 ELISA Kit; ZcytoR17 ELISA Kit
  • 缩写：
    IL31RA
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    6.25 pg/mL-400 pg/mL
  • 灵敏度：
    1.56 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human IL31RA in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:5 Average % 95
    Range % 89-99
    1:10 Average % 102
    Range % 96-107
    1:20 Average % 96
    Range % 92-103
    1:40 Average % 89
    Range % 82-94
  • 回收率：
    The recovery of human IL31RA spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 86 82-91
    EDTA plasma (n=4) 97 92-102
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    400 2.943 2.875 2.909 2.819
    200 2.387 2.246 2.317 2.227
    100 1.554 1.512 1.533 1.443
    50 0.826 0.808 0.817 0.727
    25 0.467 0.455 0.461 0.371
    12.5 0.259 0.246 0.253 0.163
    6.25 0.179 0.173 0.176 0.086
    0 0.091 0.089 0.090 　
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro.
  • 基因功能参考文献：
    1. The first demonstration of the involvement of the IL-31/IL-31R axis in cancer came from studies in patients with mycosis fungoides/Sezary syndrome, the most frequent, cutaneous T cell lymphoma. Tumor cells were shown to produce IL-31, whose serum levels correlated with pruritus intensity. PMID: 28408397
    2. The interleukin IL-31/IL-31receptor axis contributes to tumor growth in human follicular lymphoma. PMID: 25283844
    3. detected in keratinocytes and nerve fibers in the dermis of atopic dermatitis and in the neurons of normal dorsal root ganglia PMID: 24667097
    4. IL31RA is a functional receptor expressed by a small subpopulation of IL-31RA(+)/TRPV1(+)/TRPA1(+) neurons and is a critical neuroimmune link between TH2 cells and sensory nerves for the generation of T cell-mediated itch. PMID: 24373353
    5. IL-31 and IL-31RA are upregulated in patients with allergic rhinitis, and induce MUC5AC gene expression in human airway epithelial cells. PMID: 23392388
    6. IFN-gamma-induced IL-31RA upregulation in dermal microvascular endothelium is processed via JNK and PI3 kinase activation PMID: 20849534
    7. The identification of OSMR and IL31RA gene pathology provides an explanation of the high prevalence of primary cutaneous amyloidosis in Taiwan as well as new insight into disease pathophysiology. PMID: 19690585
    8. A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5. PMID: 11877449
    9. GPL is a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor PMID: 14504285
    10. the molecular mechanisms underlying GPL-mediated signal transduction PMID: 15194700
    11. IL-31 receptor alpha expression in epidermal keratinocytes is modulated by cell differentiation and interferon gamma PMID: 18580959
    12. ). Binding of IL-31 to its receptor activates Jak/STAT, PI3K/AKT and MAPK pathways.[review] PMID: 18926762

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  • 相关疾病：
    Amyloidosis, primary localized cutaneous, 2 (PLCA2)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane. Cell projection, axon.
  • 蛋白家族：
    Type I cytokine receptor family, Type 2 subfamily
  • 组织特异性：
    Expressed in CD14- and CD56-positive blood cells. Expressed in macrophages. Expressed in keratinocytes. Expressed in a subset of dorsal root ganglia neurons (at protein level). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, b
  • 数据库链接：

    HGNC: 18969

    OMIM: 609510

    KEGG: hsa:133396

    STRING: 9606.ENSP00000415900

    UniGene: Hs.55378