Human KIAA1199 ELISA Kit

Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.

1. the in-vitro anti-proliferative and pro-apoptotic effects in colorectal cancer cells that were induced by silencing cell migration inducing hyaluronan binding protein may be associated with GRP78 repression and UPR attenuation PMID: 29024602
2. CEMIP expression was increased in retinoblastoma tissues and cells. miR-140-5p inhibited CEMIP expression possibly by targeting the 3'-UTR. PMID: 29808799
3. KIAA1199 is overexpressed in pancreatic intraepithelial neoplasia. PMID: 27922049
4. Our findings revealed that KIAA1199 protein could be applied in predicting nonsmall cell lung cancer patient's outcome PMID: 28901311
5. Overexpression of KIAA1199 may contribute to increased migration of pancreatic ductal adenocarcinoma cells and predict shorter survival after surgical resection. PMID: 28012880
6. Results suggest a possible link between inflammation, induced KIAA1199 expression, and enhanced migration during pancreatic ductal adenocarcinoma (PDAC) progression. PMID: 28179576
7. Elevated KIAA1199 protein expression is associated with tumor invasion and metastasis in colorectal cancer. PMID: 28213952
8. KIAA1199 promotes migration and invasion by Wnt/beta-catenin pathway and matrix metalloproteinase-mediated epithelial-mesenchymal transition progression, and serves as a poor prognosis marker in gastric cancer. PMID: 28422983
9. CEMIP directly facilitates colon tumor growth, and high CEMIP expression correlates with poor outcome in stage III and in stages II+III combined cohorts. PMID: 26437221
10. Results provide insight into the upregulation of CEMIP within cancer and can lead to novel treatment strategies targeting this cancer cell migration-promoting gene. PMID: 26009875
11. We present evidence that high expression of KIAA1199 is associated with tumor invasion depth, TNM stage, and poor prognosis in colorectal cancer PMID: 26045799
12. Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts. PMID: 26518873
13. oncogenic protein induced by HPV infection and constitutive NF-kappaB activity that transmits pro-survival and invasive signals through EGFR signalling PMID: 25366117
14. KIAA1199 plays an important role in glycogen breakdown and cancer cell survival PMID: 25051373
15. KIAA1199 influences the proliferation, adhesion, motility, invasiveness and epithelial-to-mesenchymal transition of cancer cells, is a likely target gene of the Wnt/beta-catenin signalling pathway[review] PMID: 24573670
16. Findings indicate that KIAA1199 may play an important role in breast tumor growth and invasiveness. PMID: 24628760
17. proteins that might interact with KIAA1199 and molecular pathways in which it might play roles, were identified. PMID: 23936024
18. Results suggest that the N-terminal portion of KIAA1199 functions as a cleavable signal sequence required for proper KIAA1199 translocation and KIAA1199-mediated HAhyaluronan depolymerization. PMID: 24269685
19. KIAA1199 serves as a novel cell migration-promoting gene and plays a critical role in maintaining cancer mesenchymal status. PMID: 23990668
20. KIAA1199 is a new hyaluronan binding protein involved in hyaluronan depolymerization. PMID: 23509262
21. KIAA1199 is differentially expressed in neoplastic tissues and KIAA1199 transcripts are more abundant in the plasma of patients with either cancer or adenoma compared to controls. PMID: 22276102
22. KIAA1199 transcript and protein are highly expressed in the majority of CRCs. KIAA1199 probably participates in Wnt-signalling, affecting cell proliferation, motility, adhesion. Also, KIAA1199 has a clinical correlation to outcome in stage-II CRC patients PMID: 21772334
23. KIAA1199 is upregulated in gastric adenocarcinoma and is associated with tumor progression. PMID: 21443102
24. three possibly disease-causing point mutations PMID: 14577002
25. KIAA1199 was highly expressed in gastric cancer, and was associated with prognosis and lymph node metastasis in multivariate analyses. Taken together, KIAA1199 may be a novel gene that plays an important role in progression of gastric cancer. PMID: 19434458

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Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted. Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP-dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas.

TMEM2 family

Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein

HGNC: 29213

OMIM: 608366

KEGG: hsa:57214

STRING: 9606.ENSP00000220244

UniGene: Hs.459088