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  4. Human Matrix metalloproteinase-28(MMP28) ELISA kit

Human Matrix metalloproteinase-28(MMP28) ELISA kit

  • 中文名称：
    人基质金属蛋白酶-28(MMP28)酶联免疫试剂盒
  • 货号：
    CSB-EL014675HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Human MMP28 ELISA Kit was designed for the quantitative measurement of Human MMP28 protein in serum, plasma, tissue homogenates, cell lysates. It is a Sandwich ELISA kit, its detection range is 0.625 ng/mL-40 ng/mL and the sensitivity is 0.156 ng/mL.

  • 别名：
    Epilysin ELISA Kit; Matrix metalloproteinase 28 ELISA Kit; Matrix metalloproteinase-28 ELISA Kit; MM 28 ELISA Kit; MM28 ELISA Kit; MMP 25 ELISA Kit; MMP 28 ELISA Kit; MMP-28 ELISA Kit; MMP25 ELISA Kit; MMP28 ELISA Kit; MMP28_HUMAN ELISA Kit
  • 缩写：
    MMP28
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates, cell lysates
  • 检测范围：
    0.625 ng/mL-40 ng/mL
  • 灵敏度：
    0.156 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cancer
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Can degrade casein. Could play a role in tissues homeostasis and repair.
  • 基因功能参考文献：
    1. Circulating MMP-28 was elevated in atrial fibrillation PMID: 29729262
    2. Results suggest a crucial role of MMP9 at the early stage of carcinogenesis in the large intestine. The increase in MMP9 and TIMP1 mRNA concentration and the decrease in MMP28 in the large intestinal tissue may be a confirmation of cancer. PMID: 28293015
    3. These results proved for the first time that epilysin expression was significantly elevated in glioblastoma PMID: 25429835
    4. A decreased level of IL-33 and an elevated concentration of MMP-28 were found in coronary heart disease patients and correlated with disease severity. PMID: 24710352
    5. MMP28 mRNA expression is highest in healthy tissues when compared to diseased periodontal tissues. PMID: 24167355
    6. Data established a seven-gene (AR, ESR2, GATA3, GBX2, KRT16, MMP28 and WNT11) prognostic signature to define a subset of triple-negative breast cancer (TNBC). PMID: 23549873
    7. Over-expression of MMP28 provides protection against apoptosis induced by either serum-deprivation or treatment with a protein kinase inhibitor. PMID: 22040290
    8. Gene expression of MMP28 in the intervertebral disk is not regulated by inflammatory mechanisms, is donor-dependent and cannot be positively or negatively linked to the grade of degeneration and only weakly to the occurrence of trauma. PMID: 21801383
    9. basal expression of MMP-2, MMP-9, MMP-28, and Filaggrin was evaluated in oral keratinocytes to collect information about ability of cigarette smoke to modify basal expression pattern of these key enzymes in the absence of clinical signs in oral epithelium PMID: 21723775
    10. MMP28 is frequently overexpressed during progression of gastric carcinoma, and contributes to tumor cell invasion and metastasis. PMID: 21615884
    11. Findings presented here show the first documentation of intervertebral disc expression and production of MMP28 PMID: 20003223
    12. MMP28 gene expression is regulated by Sp1 transcription factor acetylation. PMID: 20144149
    13. Expression of MMP-21 and MMP-28 seems to associate with the Merkel cell carcinoma of lesser malignant potential. PMID: 19921252
    14. Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair. PMID: 12164918
    15. Results suggest inhibition of MMP-28 may be beneficial under conditions of dysmyelination. PMID: 18778487
    16. Data demonstrate that expression of MMP28 alters keratinocyte phenotype towards a more adhesive, less migratory behaviour. PMID: 19375502
    17. Epilysin (MMP-28) is deposited to the basolateral extracellular matrix of epithelial cells. PMID: 19379669

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Peptidase M10A family
  • 组织特异性：
    Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes. Widely expressed in several carcinomas as well. Is
  • 数据库链接：

    HGNC: 14366

    OMIM: 608417

    KEGG: hsa:79148

    STRING: 9606.ENSP00000250144

    UniGene: Hs.380710