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  4. Human Myelin P2 protein (PMP2) ELISA kit

Human Myelin P2 protein (PMP2) ELISA kit

  • 中文名称：
    人髓磷脂P2蛋白(PMP2)酶联免疫试剂盒
  • 货号：
    CSB-E09601h
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 别名：
    FABP8 ELISA Kit; M FABP ELISA Kit; MP2 ELISA Kit; Myelin FABP ELISA Kit; Myelin P2 protein ELISA Kit; MYP2_HUMAN ELISA Kit; P2 ELISA Kit; Peripheral myelin protein 2 ELISA Kit; PMP2 ELISA Kit
  • 缩写：
    PMP2
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 检测范围：
    Request Information
  • 灵敏度：
    Request Information
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cardiovascular
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
  • 基因功能参考文献：
    1. The structural characterization of the F57A mutant of P2 which shows changes in the portal region and helix alpha2 and an unfolded status upon lipid bilayer binding. Further results suggest a central role for Phe57 in regulating the opening of the portal region in human P2, and the F57A mutation disturbs dynamic cross-correlation networks in the portal region of P2. PMID: 29940944
    2. SH3TC2, PMP2, and BSCL2 pathogenic variants might be rare in Chinese Charcot-Marie-Tooth (CMT) patients. PMID: 29336362
    3. Our genetic and clinical findings in these kindred demonstrate that dominant PMP2 mutations cause Charcot-Marie- Tooth disease type 1. PMID: 27009151
    4. A fully deuterated sample of myelin P2 protein was produced identifying the neutron crystal structure. PMID: 26527266
    5. This report might expand the genetic and clinical features of Charcot-Marie-Tooth disease and a further mechanism study will enhance our understanding of PMP2-associated peripheral neuropathy. PMID: 26828946
    6. The structure of human P2 refined at the ultrahigh resolution of 0.93 A allows detailed structural analyses, including the full organization of an internal hydrogen-bonding network. PMID: 24419389
    7. the structure and function of the P2 protein from human myelin, which is able to bind both monomeric lipids inside its cavity and membrane surfaces PMID: 20421974

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 数据库链接：

    HGNC: 9117

    OMIM: 170715

    KEGG: hsa:5375

    STRING: 9606.ENSP00000256103

    UniGene: Hs.571512