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  4. Human Proteasome activator complex subunit 1(PSME1) ELISA kit

Human Proteasome activator complex subunit 1(PSME1) ELISA kit

  • 中文名称：
    人蛋白酶体激活剂复合物亚基1(PSME1)酶联免疫试剂盒
  • 货号：
    CSB-EL018915HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 别名：
    11S regulator complex alpha subunit ELISA Kit; 11S regulator complex subunit alpha ELISA Kit; 29 kD MCP activator subunit ELISA Kit; 29kD MCP activator subunit ELISA Kit; Activator of multicatalytic protease subunit 1 ELISA Kit; IFI5111 ELISA Kit; IGUP I-5111 ELISA Kit; Interferon gamma IEF SSP 5111 ELISA Kit; Interferon gamma inducible protein 5111 ELISA Kit; Interferon gamma up regulated I 5111 protein ELISA Kit; Interferon gamma up-regulated I-5111 protein ELISA Kit; MGC8628 ELISA Kit; PA28a ELISA Kit; PA28alpha ELISA Kit; Proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) ELISA Kit; Proteasome activator 28 subunit alpha ELISA Kit; Proteasome activator complex subunit 1 ELISA Kit; Proteasome activator subunit 1 ELISA Kit; PSME1 ELISA Kit; PSME1_HUMAN ELISA Kit; REG-alpha ELISA Kit; REGalpha ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    tissue homogenates, cell lysates.
  • 检测范围：
    0.19 ng/ml-12.5ng/ml
  • 灵敏度：
    0.049 ng/ml
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cell Biology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 线性度：
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
  • 基因功能参考文献：
    1. Such a modulation of proteasome activity is explained, at least in part, by the circadian expression of both Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and the proteasome activator PA28ab PMID: 26944190
    2. Results show that PA28alpha was found to be overexpressed in oral squamous cell carcinoma cell lines and tumor tissues. High expression of PA28alpha was significantly associated with recurrence and poorer overall survival. PMID: 26892607
    3. Constitutive expression of PA28 and ERAP1 in melanoma cells indicate that both interfere with MART-1(26-35) epitope generation even in the absence of IFN-gamma PMID: 26399368
    4. PA28 is a tumor marker and a potential target for therapeutic intervention in prostate cancer. PMID: 23918357
    5. Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNbeta in mouse pancreatic beta-cells. PMID: 23383295
    6. the first evidence of a novel ovarian cancer-specific marker PMID: 22532226
    7. PA28 selectively up-regulates the presentation of viral MHC class I epitopes and that down regulation PA28 in tumor cells results in impaired presentation of a human TRP2 tumor antigen. PMID: 12200048
    8. The relationship between anti-PA28alpha and Ki antibodies suggests the importance of an antigen-driven system in the induction of an autoimmune response to PA28 complex. PMID: 14760793
    9. DJ-1 and PA28alpha may have roles in the onset of hepatocarcinogenesis PMID: 17671684
    10. the 11S proteasome activator complex, Reg alpha fragment, may have a role in ovarian cancer PMID: 17939699
    11. bortezomib-adapted HL-60 cells showed increased expression and proteasome association of the 11S proteasome activator PMID: 19225532

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  • 蛋白家族：
    PA28 family
  • 数据库链接：

    HGNC: 9568

    OMIM: 600654

    KEGG: hsa:5720

    STRING: 9606.ENSP00000372155

    UniGene: Hs.75348