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  4. Human Trypsin-2(PRSS2) ELISA kit

Human Trypsin-2(PRSS2) ELISA kit

  • 中文名称：
    人胰蛋白酶原Ⅱ(Try-Ⅱ)酶联免疫试剂盒
  • 货号：
    CSB-E09623h
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：
        Try (Trypsinogen)是一种胰蛋白酶原，它在胰腺中被合成并储存在胰液中，后被激活成为胰蛋白酶，参与食物消化。Try的含量在胰腺疾病中具有重要的临床意义，例如胰腺炎、胰腺癌等，因为这些疾病会导致Try的异常分泌和激活，从而引发胰腺组织的自溶和损伤。
        j9九游会登录入口首页生物所提供的Human Trypsin-2(PRSS2) ELISA kit属于ELISA检测试剂盒，采用双抗夹心法定量检测人血清、血浆、组织匀浆样本中的Try，其灵敏度为0.19 ng/ml，检测范围为0.78 ng/ml-50 ng/ml。
     
  • 别名：
    Anionic trypsinogen ELISA Kit; EC 3.4.21.4 ELISA Kit; MGC111183 ELISA Kit; MGC120174 ELISA Kit; Protease serine 2 preproprotein ELISA Kit; Protease; serine; 2 (trypsin 2) ELISA Kit; Protease; serine; 2 ELISA Kit; Protease; serine; 2; preproprotein ELISA Kit; Prss2 ELISA Kit; Serine protease 2 ELISA Kit; TRY2 ELISA Kit; TRY2_HUMAN ELISA Kit; TRY8 ELISA Kit; TRYP2 ELISA Kit; Trypsin 2 ELISA Kit; Trypsin II ELISA Kit; Trypsin-2 ELISA Kit; Trypsinogen 2 ELISA Kit
  • 缩写：
    Try
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    0.78 ng/ml-50 ng/ml.
  • 灵敏度：
    0.19 ng/ml
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Signal Transduction
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
    降钙素原（Try）是一种由甲状腺C细胞合成的肽类激素，它参与调节钙离子代谢和降低血钙水平的生理过程。近期研究发现，Try在乳腺癌、甲状腺癌、骨髓瘤等恶性肿瘤的发生和发展中扮演着重要角色。此外，Try还与乳腺癌的分期和预后相关，具有很好的诊断和预测价值。
  • 功能：
    In the ileum, may be involved in defensin processing, including DEFA5.
  • 基因功能参考文献：
    1. evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute (RAP) and chronic pancreatitis PMID: 26110235
    2. PRSS2 single nucleotide polymorphism associated with the development of alcoholic pancreatitis. PMID: 25253127
    3. Serum trypsinogen-2 is associated with pancreatic cancer and pancreatitis. PMID: 25916077
    4. trypsin-2 over-expression enhanced tongue carcinoma cell invasion by various genetic and proteolytic mechanisms. PMID: 22909050
    5. Elevation of urine trypsinogen 2 is an independent risk factor for pancreatic fistula after pancreaticoduodenectomy. PMID: 22357509
    6. Report a simple, rapid, easy, and noninvasive urinary trypsinogen-2 test can diagnose or rule out most cases of acute pancreatitis. PMID: 22481290
    7. Data show that urinary trypsinogen-2 dipstick test is a useful test for early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. PMID: 21946810
    8. results suggest that trypsinogen-2 is a more sensitive marker than amylase, and it can be useful in early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. PMID: 21792081
    9. A genetic variant of PRSS2 may contribute to the low prevalence of pancreatitis in primary hyperparathyroidism patients. PMID: 20625975
    10. Hyperexpression of the PRSS2 gene is associated with pancreatic cancer. PMID: 20428826
    11. there was a borderline statistically significant association between pancreatic cancer and HAT/HCT but no association between pancreatic cancer and HAT, HCT. PMID: 20484960
    12. Urine trypsinogen-2 test may be an important diagnostic tool in excluding the diagnosis of acute pancreatitis; it has a negative predictive value. PMID: 20517765
    13. Results do not support the urinary trypsinogen-2 dipstick test (UTDT) to replace standard plasma amylase for the diagnosis of AP, however, the test demonstrated an adequate sensitivity to be used for rapid early screening of AP in daily clinics. PMID: 19752771
    14. Results indicate that up-regulation of anionic trypsinogen in pancreatic diseases does not affect physiological trypsinogen activation, but significantly limits trypsin generation under potential pathological conditions. PMID: 12709065
    15. High levels of pulmonary trypsin-2 may be associated with the development of bronchopulmonary dysplasia in preterm infants. PMID: 12949286
    16. G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis PMID: 16699518
    17. Our results suggest that serum trypsinogen-2 is a most useful marker for diagnosing patients with cholangiocarcinoma, and it is superior to serum CA19-9 and CEA. PMID: 17640760
    18. Co-localization of trypsin-2 and MMP-9 resulted in intracellular proMMP-9 processing that represented fully or partially activated MMP-9. PMID: 18062964
    19. A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis. PMID: 18362849
    20. A fusion with PRSS1 is associated with hereditary pancreatitis. PMID: 18461367
    21. primary role of trypsinogen sulfation in humans is to stimulate autoactivation of PRSS1 PMID: 18986305
    22. The p.G191R variant protected against alcoholic and idiopathic chronic pancreatitis as well as alcoholic acute pancreatitis in Japan. PMID: 19052022
    23. G191R PRSS2 is a rare allele in the Indian population and the data suggest a nonsignificant trend towards a protective effect from tropical calcific pancreatitis in Indians. PMID: 19077465

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  • 亚细胞定位：
    Secreted, extracellular space.
  • 蛋白家族：
    Peptidase S1 family
  • 组织特异性：
    Expressed in Paneth cells, at the base of small intestinal crypts.
  • 数据库链接：

    HGNC: 9483

    OMIM: 601564

    KEGG: hsa:5645

    UniGene: Hs.449281