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  4. Human granulocyte chemotactic protein-2,GCP-2 ELISA Kit

Human granulocyte chemotactic protein-2,GCP-2 ELISA Kit

  • 中文名称：
    人粒细胞趋化蛋白-2(GCP-2/CXCL6)酶联免疫试剂盒
  • 货号：
    CSB-E09990h
  • 规格：
    96T/48T
  • 价格：
    ￥3200/￥2500
  • 其他：

产品详情

  • 产品描述：

    This human GCP-2 ELISA kit employs the quantitative sandwich enzyme immunoassay technique to measure the levels of human GCP-2 in serum, plasma, or tissue homogenates. It also uses the enzyme-substrate chromogenic reaction to visualize and analyze the analyte levels through the color intensity. The intensity of the colored product is in direct proportion to the GCP-2 levels in the sample and is measured at 450 nm through a microplate reader.

    GCP-2, also known as CXCL6, is a neutrophil-recruiting ELR+ chemokine that signals through the receptors CXCR1 and CXCR2 that are expressed on neutrophils. CXCL6-CXCR1/2 signaling mediates multiple biological processes such as inflammation, immunoreaction, cell growth, and metastasis in humans. It also promotes human hepatocyte proliferation through the CXCR1-NF-κB pathway and suppresses collagen I secretion by hepatic stellate cells. CXCL6 is involved in cancer angiogenesis, metastasis, and immune response. CXCL6 promotes the growth and metastasis of various cancers, including non-small cell lung cancer and osteosarcoma (OS).

  • 别名：
    C X C motif chemokine 6 ELISA Kit; Chemokine (C X C motif) ligand 6 ELISA Kit; Chemokine alpha 3 ELISA Kit; CKA 3 ELISA Kit; CKA-3 ELISA Kit; CKA3 ELISA Kit; CXCL 6 ELISA Kit; CXCL6 ELISA Kit; CXCL6_HUMAN ELISA Kit; GCP 2 ELISA Kit; GCP-2 ELISA Kit; Granulocyte chemotactic protein 2 ELISA Kit; N-processed variant 3 ELISA Kit; SCYB6 ELISA Kit; Small inducible cytokine B6 ELISA Kit; Small inducible cytokine subfamily B (Cys X Cys) member 6 ELISA Kit; Small inducible cytokine subfamily B (Cys X Cys) member b ELISA Kit; Small-inducible cytokine B6 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    78 pg/mL-5000 pg/mL
  • 灵敏度：
    19.5 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

引用文献

产品评价

靶点详情

  • 功能：
    Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).
  • 基因功能参考文献：
    1. CXCL6 could reduce the expression of miR-515-5p in NSCLC cells; MiR-515-5p acted as a tumor suppressor by targeting CXCL6 in non-small cell lung cancer cell cells. PMID: 29136957
    2. Study has provided the first report of fibroblast-derived CXCL12 enhancement of CXCL6 secretion in colon cancer cells, and of both CXCL12 and CXCL6 co-operatively regulating metastasis through the PI3K/Akt/mTOR signaling pathway. PMID: 28811711
    3. CXCL6 expression is upregulated by Fli1 deficiency in fibroblasts and endothelial cells, potentially contributing to the development of fibrosis and vasculopathy in the skin, lung, and heart of systemic sclerosis. PMID: 28507181
    4. CXCL6 level is high in the serum of chronic hepatitis B patients.CXCL6 promotes human hepatocyte proliferation through the CXCR1-NFkappaB pathway and inhibits collagen I secretion by hepatic stellate cells. PMID: 27032929
    5. The role of PITX2 in glaucoma may be mediated partly by regulating the expression of CXCL6 and BBS5 and thus affecting immune functions and intraocular pressure. PMID: 27520585
    6. The neutrophil-recruiting chemokine GCP-2/CXCL6 is expressed in cystic fibrosis airways and retains its functional properties after binding to extracellular DNA. PMID: 25993443
    7. HIF-1alpha promotes HCC progression and metastasis by upregulating CXCL6 transcription in HCC cells. PMID: 25323032
    8. Expression of the CXCL8, CXCL6 and CXCL1 genes are under the primary control of 1,25-dihydroxyvitamin D3 and its receptor. PMID: 24250750
    9. Data suggest that expression of CXCL6 in trophoblasts is up-regulated during pregnancy development/placentation; CXCL6 expression inhibits trophoblast cell migration and invasion by down-regulating activity of MMP2 (matrix metalloproteinase 2). PMID: 23814098
    10. Overexpression of GCP-2 in mesenchymal stem cells has the potential to enhance their angiogenic and survival properties. PMID: 22886775
    11. Studies show that functional blocking of GCP-2 inhibits tumor growth and metastases. PMID: 21236563
    12. The aim of this study was to investigate the role of the transcription factors, AP-1 and NF-kappaB, in IL-6 and CXCL8 regulation in Jurkat T-cells. PMID: 20507572
    13. The level of expression of granulocyte chemotactic protein 2 correlates with the severity of periodontitis and appears to act as a yet unrecognized functional adjunct to interleukin-8 in pathological gingival tissues. PMID: 18842116
    14. results suggest that granulocyte chemotactic protein-2 is an additional ELR(+)-CXC chemokine expressed in endometrial stromal cells PMID: 12524079
    15. induction in mesenchymal cells by interleukin-1beta and down-regulation by interferon-gamma PMID: 12533683
    16. Neutrophil recruitment to inflammatory sites is mediated by two related receptors: CXCR1 and CXCR2. Both receptors share two ligands, interleukin-8 (CXCL8) and GCP-2 (CXCL6). PMID: 12628493
    17. expression in inflamed intestinal tissue in Crohn's disease PMID: 15214047
    18. production of GCP-2 by endothelial cells within the tumor can contribute to tumor development through neovascularization due to endothelial cell chemotaxis and to tumor cell invasion and metastasis PMID: 15652347
    19. LDL lipoprotein subunit L5 induces human umbilical vein endothelial cells (HUVEC) to express CXCL6. PMID: 17022986
    20. These findings indicate that the equilibrium between angiostatic and angiogenic factors during inflammation and tumor progression is rather complex and differs depending on the chemokine, cell type, and stimulus. PMID: 17827342
    21. These observations suggest a role for CXCL6 in the innate immune response to microbial invasion of the amniotic cavity. PMID: 18782286
    22. Report gonadotropin-releasing hormone-regulated CXCL6 expression in human placentation. PMID: 19369450

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine alpha (chemokine CxC) family
  • 数据库链接：

    HGNC: 10643

    OMIM: 138965

    KEGG: hsa:6372

    STRING: 9606.ENSP00000226317

    UniGene: Hs.164021