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  4. Human insulin-like growth factors binding protein 1,IGFBP-1 ELISA Kit

Human insulin-like growth factors binding protein 1,IGFBP-1 ELISA Kit

  • 中文名称：
    人胰岛素样生长因子结合蛋白1(IGFBP-1)酶联免疫试剂盒
  • 货号：
    CSB-E04586h
  • 规格：
    96T/48T
  • 价格：
    ￥3200/￥2500
  • 其他：

产品详情

  • 产品描述：

    The product CSB-E04586h is a sandwich ELISA kit developed to measure concentrations of human IGFBP1 in serum, plasma, or tissue homogenates. This assay uses the sandwich enzyme immunoassay technique in combination with the enzyme-substrate chromogenic reaction to quantify the analyte in the sample. The color develops positively to the amount of IGFBP1 in samples. The color intensity is measured at 450 nm via a microplate reader.

    IGFBP1 is produced dominantly in the liver, heart, and kidney. It binds to insulin-like growth factor (IGF) and regulates IGF actions in somatic growth, development, and aging. IGFBP-1 not only is an important determinant of IGF activity but also enhances glucose uptake in peripheral tissues and decreases glucose output in the liver. It regulates cell proliferation, migration, and glucose metabolism by activating integrin-ILK/FAK/PTEN signaling through integrin receptors on the cell membrane. Low circulating levels of IGFBP1 are related to insulin resistance and predict the development of type 2 diabetes. Dysregulation of IGFBP1, as well as IGFs in serum and cervical secretions, induces metabolic disease and cardiovascular disease. Overexpression of IGFBP1 has been shown to improve impaired glucose tolerance.

  • 别名：
    AFBP ELISA Kit; Alpha pregnancy associated endometrial globulin ELISA Kit; Amniotic fluid binding protein ELISA Kit; Binding protein 25 ELISA Kit; Binding protein 26 ELISA Kit; Binding protein 28 ELISA Kit; Growth hormone independent binding protein ELISA Kit; hIGFBP 1 ELISA Kit; hIGFBP1 ELISA Kit; IBP 1 ELISA Kit; IBP-1 ELISA Kit; IBP1 ELISA Kit; IBP1_HUMAN ELISA Kit; IGF binding protein 1 ELISA Kit; IGF BP25 ELISA Kit; IGF-binding protein 1 ELISA Kit; IGFBP 1 ELISA Kit; IGFBP-1 ELISA Kit; IGFBP1 ELISA Kit; Insulin like growth factor binding protein 1 ELISA Kit; Insulin-like growth factor-binding protein 1 ELISA Kit; Placental protein 12 ELISA Kit; PP 12 ELISA Kit; PP12 ELISA Kit
  • 缩写：
    IGFBP1
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    1.56 ng/mL-100 ng/mL
  • 灵敏度：
    0.39 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Signal Transduction
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
  • 基因功能参考文献：
    1. In patients with acute myocardial infarction without previously known diabetes, high insulin-like growth factor-binding protein 1 was associated with long-term all-cause and cancer mortality but not with cardiovascular events. PMID: 29992830
    2. Study shows that the 3'-untranslated region of IGFBP1 mRNA is targeted by miR-542-3p. The results suggest that miR-542-3p plays an important role in endometrial decidualization by regulating the expression of major decidual marker genes. PMID: 28051155
    3. we demonstrated that IGFBP-1 suppress the migration of BGC-823 gastric cancer cells and play a protective role in the process of H. pylori-induced gastric cancer. PMID: 28864349
    4. hIGFBP1 affects endothelial cell responses and acceleration of endothelial regeneration in transgenic mouse model. PMID: 29186427
    5. Vaginal PAMG-1 in patients with a cervical length of 15-30 mm is highly predictive of imminent spontaneous preterm delivery. PMID: 28613021
    6. There was underexpression of the majority of genes after sunitinib treatment. The lower expression levels of IGFBP1, CCL20, CXCL6 and FGB were confirmed by qRT-PCR in all cases. The downregulation of gene expression leads us to search for methylation as a mechanism of action of the tyrosine kinase inhibitors PMID: 27834463
    7. A panel consisting of IGFBP1, KIM1, GCLC and GSTM1 genes could be used in combination for early screening of CKDu, whereas these genes in addition with FN1, IGFBP3 and KLK1 could be used to monitor progression of CKDu. The regulation of these genes has to be studied on larger populations to validate their efficiency for further clinical use. PMID: 28103909
    8. We report interactions between CSNK-2beta and IGFBP-1 as well as mTOR and CSNK-2beta, providing strong evidence of a mechanistic link between mTOR and IGF-I signaling, two critical regulators of cell growth via CSNK-2. PMID: 29037858
    9. We conclude that low BDNF and high LCN2 and NF-L levels are associated with Multiple Sclerosis (MS) pathogenesis, and high IGFBP1level is a biomarker for female MS only, suggesting different MS progression pathways between the sexes. LCN2 is a candidate predictor of response to natalizumab treatment, and NF-L is a candidate predictor of clinically isolated syndrome's (CIS) conversion into MS. PMID: 29108879
    10. Results show that IGFBP-1 transcription and FoxO1 expression are dysregulated in tamoxifen-resistant cancer cells. PMID: 28096479
    11. IGBFBP-1 levels increased significantly in type 2 diabetic patients with acute coronary syndrome on sitagliptin. PMID: 27190088
    12. Women with higher IGFBP-1 were more likely to have a low relative muscle mass. PMID: 28732569
    13. Levels of serum IGFBP-1 were shown to be significantly higher in patients with NPCs. PMID: 28143425
    14. Levels of blood IGFBP-1 in pre- and post-menopausal rheumatoid arthritis patients were significantly higher in comparison to the control group. PMID: 27775453
    15. ALDH1A1 and IGFBP1 are differentially overexpressed in CLM and may play a dual role, functioning as both tumor suppressors and metastasis promoters in CRC PMID: 27152521
    16. Moreover, a prospective human study showed that having high IGFBP1 levels reduces the risk of developing type-2 diabetes by more than 85%. PMID: 27516442
    17. Study provides evidence that elevated values of IGFBP -1 in cervical secretion are highly correlated with preterm labor. PMID: 27452330
    18. IGFBP1 levels were higher in patients with multivessel than those with single-vessel lesions; Circulating IGFBP1 level positively correlated with the severity of coronary artery disease. PMID: 28316362
    19. The reduced affinity of fibrinogen for IGFBP-1 accompanying diabetes may potentially shift the equilibrium to liberate more IGFBP-1 PMID: 27919172
    20. Plasma IGFBP-1 was significantly associated with plasma EPO concentration in acute kidney injury, suggesting an unknown mechanism related to systemic stress conditions for EPO regulation in AKI. PMID: 26479890
    21. Results show that fibrinogen forms complexes with IGFBP-1 under physiological conditions. Several experimental approaches have confirmed that complexes are co-isolated with fibrinogen from plasma, they are relatively stable, and they appear as a general feature of human plasma. PMID: 27260393
    22. Serum IGFBP-1 and -2 are increased in idiopathic pulmonary fibrosis and IGFBP-2 may be reduced by anti-fibrosing therapy. PMID: 27215343
    23. The reference change values values for serum IGFBP-1 were 59.9%, 83.2% and 93.0% and for fasting serum insulin were 68.5%, 79.0% and 93.4% for subjects with normal glucose tolerance, impaired fasting glucose, and impaired glucose tolerance, respectively. PMID: 23548151
    24. mTOR inhibition constitutes a mechanistic link between hypoxia, reduced IGF-I bioavailability and fetal growth retardation. PMID: 26714229
    25. the hepatokine IGFBP1 is a critical liver-bone hormonal relay that promotes osteoclastogenesis and bone resorption as well as an essential mediator of FGF21-induced bone loss PMID: 26456333
    26. There was a positive correlation between the IGFBP1 levels of and those of inflammatory mediators in HIV Infections. PMID: 25890304
    27. trend towards higher cord blood values in intrauterine growth restriction observed PMID: 26118397
    28. The amino acid response and mTOR independently regulate IGFBP-1 secretion and phosphorylation in response to decreased amino acid availability. PMID: 25957086
    29. Insulin-like growth factor 1 receptor blockade can inhibit glioblastoma growth by different mechanisms, including direct effects on the tumor cells as well as indirect anti-angiogenic effects. PMID: 25543125
    30. gene expression analysis of human breast tumors showed that high expression of IGFBP mRNA was strongly correlated with good prognosis but not when MMP9 mRNA was also highly expressed PMID: 26025665
    31. study shows up-regulation of MCSF in GBM via a SYK-PI3K-NFkappaB-dependent mechanism and identifies IGFBP1 released by microglial cells as a novel mediator of MCSF-induced angiogenesis PMID: 26245897
    32. Activation of IGFBP1 by pregnane X receptor alters the morphology of hepatocellular carcinoma cells and regulates cell migration. PMID: 26232425
    33. IGFBP1 in epithelial circulating tumor cells as a potential response marker to selective internal radiation therapy in hepatocellular carcinoma PMID: 25123037
    34. Data suggest that expression of IGFBP1 in hepatocytes can be regulated by carnosine, a dietary factor; carnosine down-regulates expression of IGFBP1 in Hep G2 cells; mechanism involves suppression of HIF1A (hypoxia inducible factor 1 alpha subunit). PMID: 25869614
    35. Suggest that IGFBP-1 inhibits the invasion and metastasis of HCC cells and that IGFBP-1 may be useful as a valuable marker for the prognosis of patients with HCC. PMID: 25337205
    36. Variations in relative quantities of IGFBP-1 monomers and complexes in different tumor types were much more pronounced than those of IGFBP-2. PMID: 25746666
    37. term placental explants, but not their conditioned medium, can de-phosphorylate IGFBP-1 through the action of placental alkaline phosphatase PMID: 24856042
    38. The predictive value of IGFBP1 in cervical secretion as bedside test for prediction of preterm labor in symptomatic women was studied. PMID: 25597167
    39. Data suggest that up-regulation of IGFBP1 in vaginal smears (as a biological marker for presence of amniotic fluid) may be useful point-of-care test for diagnosis of premature rupture of fetal membranes. PMID: 24612210
    40. In the second trimester, rapid cervical phIGFBP-1 testing in asymptomatic twin pregnancies has a poor performance in predicting spontaneous preterm delivery PMID: 24436153
    41. This paper provides a brief overview of the structure and regulation of IGFBP-rP1 and its various biological functions in cancer--{review} PMID: 24513543
    42. DeltaIGFBP-1 as a biomarker of hepatic insulin resistance PMID: 24056811
    43. According to this study IGFBP-1 is a specific marker for preterm delivery in pregnant women with clinical symptoms. PMID: 24919336
    44. Amniotic fluid samples collected after labour onset contained proteolytic activity that generated 12- and 19-kDa IGFBP-1 fragments that did not bind to 125I-IGF-I. This activity was not detected in amniotic fluid collected prior to labour onset. PMID: 23183724
    45. Serum glycodelin levels did not predict endometrial receptivity in patients undergoing in vitro fertilization. PMID: 23585335
    46. Pyridoxal may induce the expression of IGFBP1 in hepatoma cells via a mechanism involving the ERK/cJun pathway. PMID: 23942851
    47. elevated insulin-like growth factor binding protein 1 appears to be associated with shorter time to castration resistant prostate cancer and lower overall survival in men with metastatic prostate cancer PMID: 24132762
    48. C/EBPbeta regulates the expression of IGFBP-1 and PRL by altering the histone acetylation status of their promoters but differently regulates Mn-SOD gene expression in human ESC during decidualization PMID: 24248464
    49. The median concentrations of first-trimester vaginal and cervical phIGFBP-1 are higher in women with spontaneous preterm delivery at <32 and <37 weeks gestation. PMID: 23408645
    50. FOXO1/IGFBP-1 axis is essential for PRB-dependent growth inhibition of endometrial epithelial cells PMID: 23603247

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    HGNC: 5469

    OMIM: 146730

    KEGG: hsa:3484

    STRING: 9606.ENSP00000275525

    UniGene: Hs.642938