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  4. Human insulin-like growth factors binding protein 4,IGFBP-4 ELISA Kit

Human insulin-like growth factors binding protein 4,IGFBP-4 ELISA Kit

  • 中文名称：
    人胰岛素样生长因子结合蛋白4(IGFBP-4)酶联免疫试剂盒
  • 货号：
    CSB-E04592h
  • 规格：
    96T/48T
  • 价格：
    ￥3200/￥2500
  • 其他：

产品详情

  • 产品描述：
        IGFBP4 (Insulin-like growth factor-binding protein 4)是一种IGF结合蛋白，在细胞生长和凋亡中具有重要作用。IGFBP4不仅可以抑制IGF诱导的细胞增殖，还可以独立于IGF影响细胞增殖。在某些类型的癌症中，IGFBP4的表达水平会下降，例如肺癌和乳腺癌。此外，IGFBP4也在某些神经系统疾病中发挥作用。生物学含义上，IGFBP4可作为治疗疾病的潜在靶点。
        j9九游会登录入口首页生物所提供的Human insulin-like growth factors binding protein 4,IGFBP-4 ELISA Kit属于ELISA检测试剂盒，采用双抗夹心法定量检测人血清、血浆、组织匀浆样本中的IGFBP4，其灵敏度为15.6 ng/mL，检测范围为62.5 ng/mL-4000 ng/mL。
     
  • 别名：
    AI875747 ELISA Kit; BP 4 ELISA Kit; BP4 ELISA Kit; Deb2 ELISA Kit; HT29 IGFBP ELISA Kit; IBP 4 ELISA Kit; IBP-4 ELISA Kit; IBP4 ELISA Kit; IBP4_HUMAN ELISA Kit; IGF binding protein 4 ELISA Kit; IGF-binding protein 4 ELISA Kit; IGF-BP4 ELISA Kit; IGFBP 4 ELISA Kit; IGFBP-4 ELISA Kit; IGFBP4 ELISA Kit; Insulin Like Growth Factor Binding Protein 4 ELISA Kit; Insulin-like growth factor-binding protein 4 ELISA Kit
  • 缩写：
    IGFBP4
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    62.5 ng/mL-4000 ng/mL
  • 灵敏度：
    15.6 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Signal Transduction
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
    胰岛素样生长因子结合蛋白4（IGFBP4）是一种重要的胰岛素样生长因子（IGF）调节蛋白，其主要功能是通过与IGF1和IGF2结合调节IGF信号通路。IGFBP4在肿瘤发生和发展中扮演重要角色，其表达水平与多种恶性肿瘤相关，如乳腺癌、卵巢癌、前列腺癌等。IGFBP4不仅参与肿瘤细胞增殖和生存调控，还影响肿瘤血管生成和免疫逃逸。
  • 功能：
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • 基因功能参考文献：
    1. The s also identified single-nucleotide polymorphisms in NRP2 and IGFBP4 loci that increase and reduce risk of lichen planus in hepatitis C virus-infected patients, respectively. PMID: 28065765
    2. the results of this study raise the possibility that human mesenchymal stem cells actions involve a negative-regulatory mechanism that suppresses Treg proliferation by releasing IGFBP-4 PMID: 28724578
    3. IGFBP-4 maybe act as a potential negative regulator in the progression of lung cancer through downregulation of COX-2. PMID: 28150906
    4. Patients with type 2 Diabetes Mellitus had lower serum concentrations of IGFBP-4 compared to controls. PMID: 28179448
    5. Data show that insulin-like growth factor binding protein-4 (IGFBP-4) was significantly elevated in lupus nephritis, particularly those with renal pathology chronicity changes. PMID: 27019456
    6. The present study provides the first evidence that apoptosis inhibitor of macrophages binds to IGFBP2, 3 and 4. PMID: 26135353
    7. Data show that co-transfection with cDNA encoding stanniocalcin-1 abrogates the proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) toward IGF-binding protein 4 (IGFBP-4). PMID: 26195635
    8. PLasma IGFBP-4 levels are not acutely altered following myocardial infarction treated with heparin and percutaneous coronary intervention. PMID: 25489725
    9. High IGFBP-4 fragment levels were associated with increased all-cause and cardiovascular mortality rates in T1D patients with and without diabetic nephropathy. PMID: 26046968
    10. Data indicate co-localization of insulin-like growth factor binding proteins IGFBP-4, IGFBP-5 in the syncytiotrophoblast layer of first trimester placental villi as early as 5 weeks of gestational age. PMID: 25475528
    11. IGF-1/IGFbp4 signaling regulated the post-developmental adipose tissue expansion. PMID: 24778188
    12. Despite the relation of CT-IGFBP4 to a more severe coronary artery disease, CT- and NT-IGFBP4, in contrast to our report based on total PAPP-A, failed to predict any long-term outcomes in patients with stable cardiovascular disease. PMID: 24201068
    13. these findings demonstrate an oncogenic property for IBP in promoting the metastatic potential of breast cancer cells. PMID: 23975422
    14. PAPP-A and IGFBP-4 gene expression (microarray analysis) was significantly upregulated in IL-1beta- or TNF-alpha-exposed cells. PMID: 24060054
    15. IGFBP-4 modulates the efficiency of estrogen-triggered activation of the Akt/PKB signaling pathway which has been associated with growth factor/ ERalpha cross-talks. PMID: 23499909
    16. Epigenetic silencing of UCHL1 and IGFBP4 in giant cell tumors may be important for malignant transformation of the cells PMID: 23603559
    17. IGFBP-4 was by far the most predominant IGFBP by immunoassay PMID: 23079385
    18. role of IGFBP-4 in regulating IGF bioavailability and provide new clues for the prevention and treatment of FGR (Fetal growth restriction). PMID: 22689691
    19. IGF1 haplotypes are associated with genetic susceptibility to high myopia in Chinese adults, whereas IGFBP3 and IGFBP4 are unlikely to be important in the genetic predisposition to high myopia PMID: 22332214
    20. The resistance of VEGF-stimulated angiogenesis to IGFBP-4 inhibition appears to depend on sustained activation of p38 MAPK as blocking its activity restored the anti-angiogenic effects of IGFBP-4 on VEGF-induced blood vessel growth in vivo PMID: 22134921
    21. This study demonistrated that IGFBP4 was significantly decreased in skeletal muscel in patient with amyotrophic lateral sclerosis. PMID: 22246875
    22. circulating IGFBP-4 levels are not influenced by secondary hyperparathyroidism in vitamin D deficiency rickets PMID: 21274331
    23. This is a first report documenting that IGFBP-4 expression in RCC activates cell growth, metastasis, Wnt/beta-catenin signaling and may be involved in RCC metastasis. PMID: 21207373
    24. These findings suggest that the expression of IGFBP-4 in adenocarcinoma cells in vivo is downregulated by epigenetic silencing in association with tumor differentiation, resulting in disruption of the mechanism of IGFBP-4-mediated growth inhibition. PMID: 21166939
    25. enterocyte HT-29 cell differentiation correlates with an increase in IGFBP-4 levels PMID: 12163000
    26. results are the first evidence of IGF-independent IGFBP-4 actions on granulosa cell steroidogenesis PMID: 12193384
    27. role in sequestration of insulin-like growth factor-1 and consequent impairment of insulin-like growth factor-1 action in skeletal tissue PMID: 12733722
    28. A novel SP3 binding site was identified in the promoter of IGFBP4. PMID: 14767471
    29. IGFBP-4 proteolysis and local regulation of IGF availability may be altered in malignant ovarian epithelial cells PMID: 15146551
    30. Data suggested that growth factor- and cytokine-mediated changes in IGFBP abundance regulate postnatal fibroblast cell. proliferation PMID: 15204833
    31. IGFBP-4 is a novel dB-cAMP-induced anti-angiogenic and anti-tumorigenic mediator that may be a promising candidate for glioblastoma therapy. PMID: 16586492
    32. Overexpression of IGFBP-4 in vivo has been reported to decrease the growth of prostate cancer and altered expression of IGFBP-4 in vivo in colon and other cancers needs to be explored as locally available IGFs appear to stimulate mitogenesis. (review) PMID: 16685432
    33. local increased collagen synthesis was preceded by an elevation of local concentration of IGFBP-4, suggesting that IGFBP-4 may have a key role in the IGF-axis effect on the human collagen synthesis in vivo PMID: 16973813
    34. the IGF system may have a limited role in the pathogenesis of GCT with PAPP-A subserving a function other than IGFBP-4 proteolysis PMID: 17177834
    35. Ratios between IGFBPs and IGF (insulin-like growth factors), different IGFBPs, sequential proteolytic cleavage of IGFBPs, and association of activating proteinases are key elements in the regulation of IGF receptor stimulation. PMID: 17312271
    36. IGFBP-4 may have a role in increasing necrosis and apoptosis, but in decreasing mitosis PMID: 17824980
    37. conclusion: decreased IGFBP-4 tumor expression might be a step in the progression from primary to metastatic melanoma; data lend support to a recently-described novel tumor suppressor role of secreting IGFBPs in melanoma PMID: 19025658
    38. IGFBP4, which can inhibit IGF action, also increased during in-vitro decidualization of cultured human ESCs. PMID: 19038974

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    HGNC: 5473

    OMIM: 146733

    KEGG: hsa:3487

    STRING: 9606.ENSP00000269593

    UniGene: Hs.462998