Human low-density lipoprotein-receptor-related protein,LRP-6 ELISA Kit

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.

1. knockdown of LRP6 inhibited the cell viability by activation of Drp1 in glucose deprived-cardiomyocytes. PMID: 29864925
2. Three rare missense mutations (c.1514A>G, p.Y505C); c.2984A>G, p.D995G; and c.4280C>A, p.P1427Q) of the LRP6 gene were identified in Chinese NTD patients. The Y505C mutation is a loss-of-function mutation on both WNT/beta-catenin and PCP signaling. The D995G mutation partially lost inhibition on PCP signaling without affecting WNT/beta-catenin signaling. The P1427Q mutation dramatically increased WNT/beta-catenin signa... PMID: 28960852
3. LRP6 endocytosis proceeds by two routes, depending on the presence of LDL, and that LRP6 controls the intracellular destination of NPC1L1 in hepatocytes. PMID: 28821575
4. High Expressions of LRP6 is associated with cancer. PMID: 28418856
5. LRP6 expression was found to be upregulated in oral squamous cell carcinoma tissues, and correlated with a cluster of clinicopathologic parameters, including smoking, drinking, tumor differentiation status, lymph node metastasis and survival time. PMID: 28880263
6. CCN2 plays a promoting role in hepatocellular carcinoma (HCC)progression through activating LRP6 in a HSPGs-dependent manner. Heparin in combination with chemotherapy has a synergic effect and could be a treatment choice for HCCs with a high CCN2 expression. PMID: 28870205
7. Increased LRP6 gene expression is associated with colorectal cancer. PMID: 28387660
8. Therefore, our study demonstrates that miR-183 is a tumor suppressor microRNA that plays a major role in OS. PMID: 29402412
9. data suggest that LRP6 promotes negative breast cancer cell migration and invasion by regulating the expression and function of S100A4 via the Wnt/beta-catenin signaling pathway PMID: 28247948
10. sustained activation of Wnt/beta-catenin signaling due to abrogation of Merlin-mediated inhibition of LRP6 phosphorylation may be a cause of Neurofibromatosis type II disease. PMID: 27285107
11. LRP6 ectodomain becomes highly compact upon complexation with the Wnt antagonist Dkk1, suggesting a potential role for the ectodomain conformational change in the regulation of receptor oligomerization and signaling. PMID: 28052259
12. identify ANGPTL4 as a Wnt signaling antagonist that binds to syndecans and forms a ternary complex with the Wnt co-receptor Lipoprotein receptor-related protein 6 PMID: 29017031
13. The s show that folding of the Wnt signaling coreceptor LRP6 is promoted by ubiquitination of a specific lysine, retaining it in the ER while avoiding degradation. PMID: 27751231
14. Taken together, this study reveals evidence demonstrating a mechanism by which the LPR6/ GSK3beta/E2F1 axis-upregulated LSH promoted gliomas. PMID: 28042322
15. Structure of the dual-mode Wnt regulator Kremen1 and insight into ternary complex formation with LRP6 and DKK1 have been presented. PMID: 27524201
16. VAP1 cleaved the extracellular region of LRP6 at Glu1196-Leu1197, the C-terminus of the 4th propeller domain. This cleavage removes four inhibitory beta-propeller structures, resulting in activation of LRP5/6. PMID: 28425175
17. We identified a frameshift (c.4594delG, p.Cys1532fs) and a canonical splice-site mutation (c.3398-2A>C, p.?) in LRP6, respectively, in the patient with tooth agenesis (TA) and orofacial clefting (OFC) and in the patient with severe TA only. Mutations in LRP6 cause TA in humans PMID: 26963285
18. findings revealed an unrecognized role of Caprin-2 in facilitating LRP5/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14, Cyclin Y, and LRP5/6. PMID: 27821587
19. results suggest that miR-29b inhibits expression of LRP6 and HuR post-transcriptionally, thus playing a role in the regulation of IEC proliferation and intestinal epithelial homoeostasis. PMID: 27089893
20. Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery Disease. PMID: 27455246
21. LncRNA PTCSC3 inhibits the proliferation and migration of glioma cells and suppresses Wnt/beta-catenin signaling pathway by targeting LRP6 PMID: 28187755
22. Accordingly, we propose that the anti-fibrotic activity of adiponectin may be mediated through AdipoR1/R2 receptors PMID: 26797284
23. findings suggest that rescuing LRP5/6-mediated Wnt signaling improves neuronal cell survival and reduces tau phosphorylation, which support the hypothesis that Wnt signaling might be an attractive therapeutic strategy for managing AD PMID: 25959626
24. Results suggest that miR-126 functions as a tumor-suppressive miRNA by targeting LRP6 regulating Wnt/beta-catenin signaling pathway in papillary thyroid carcinoma. PMID: 26239517
25. miR513c functions as a tumor suppressor miRNA, mediated predominantly through the direct suppression of the expression of LRP6. PMID: 26063413
26. The interaction between Wnt isoforms and their LRP6 cognate receptor depends on the jutting loop present in Wnt3a but absent in Wnt5b. PMID: 25425204
27. LRP6 and VEGF levels in the vitreous body from patients with proliferative diabetic retinopathy were increased and correlated mutually. PMID: 26120271
28. Lrp6 binds to Frizzled, preventing Frz-regulated non-canonical Wnt pathway activation and further non-canonical pathway-mediated tumour metastasis. PMID: 25902418
29. No mutations in LRP5 and LRP6 could be identified PMID: 25783012
30. LRP6 variants may be associated with risk of ischaemic stroke. PMID: 26031789
31. Particularly for TNBC associated with Skp2/LRP6 overexpression. PMID: 25358452
32. Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia. PMID: 26387593
33. LRP6 variants outside of YWTD repeats could potentially predispose embryos to neural tube defectss, whereas Lrp6 modulation of Wnt/planar cell polarity signaling would be more essential than its canonical pathway role in neural tube closure. PMID: 25546815
34. the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2. PMID: 25240815
35. High LRP6 expression is associated with glioblastoma. PMID: 25301448
36. LRP6 (and Wnt signaling) are significantly downregulated in Alzheimer's disease brains. PMID: 25242217
37. The LRP6 rs10845498 SNP is associated with a reduced risk of lung SCC, while tobacco smoke increases the risk PMID: 24843317
38. The LRP6 tyrosine mutant increased in signaling activation in response to Wnt3a/beta-catenin stimulation. PMID: 25143377
39. The results suggested that the lack of affinity between human DKK3 and human LRP5/6 results from: i) insertion of the 7 amino acids, and ii) P258 in human DKK3. PMID: 24743782
40. results demonstrated that the novel loss-of-function variants identified in this study might contribute to disease liability in a subset of coronary artery disease (CAD) and defects in Wnt signal activation might be important contributing factors for the onset of CAD PMID: 24427284
41. Rottlerin is a novel LRP6 inhibitor, promoting protein degradation. PMID: 24607787
42. This study demonstrates the association of rare and novel missense mutations in LRP6 that is an inhibitor rather than an activator of the non-canonical planar cell polarity pathway with human neural tube defects. PMID: 24203697
43. Data provides the first evidence that LRP6 rs2302685 polymorphism is associated with an increased risk of MI in Chinese subjects, and the association is more evident among younger individuals, which probably due to the elevated LDL-C levels. PMID: 24906453
44. LRP6 may influence glucose metabolism in type II fibers of human skeletal muscles. PMID: 24457908
45. Syndecan-1 modulates the cancer stem cell phenotype via regulation of the Wnt and IL-6/STAT3 signaling pathways PMID: 24392029
46. Data indicate that miR-202 suppresses the expression of LRP6 (low-density lipoprotein receptor-related protein 6) by binding to the 3'-untranslated region (UTR) of its mRNA. PMID: 24704686
47. LRP6 was identified as a new target of miR-183, and restoration of the expression of LRP6 rescues the effects induced by miR-183 in retinoblastoma cells. PMID: 24289859
48. GSK3 is sequestered into multivesicular bodies through and interaction between p120-catenin/cadherin and LRP5/6. PMID: 24412065
49. Results indicate that Lrp6 mediates not only canonical Wnt signaling, but can also modulate non-canonical pathways involving RhoA-dependent mechanisms to impact neurulation, possibly through intracellular complexes with DAAM1. PMID: 23773994
50. Data show that beta-arrestins regulate Wnt3a-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation by the regulation of the membrane dynamics of Amer1. PMID: 24265322

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Coronary artery disease, autosomal dominant, 2 (ADCAD2); Tooth agenesis, selective, 7 (STHAG7)

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Membrane raft.

LDLR family

Widely coexpressed with LRP5 during embryogenesis and in adult tissues.

HGNC: 6698

OMIM: 603507

KEGG: hsa:4040

STRING: 9606.ENSP00000261349

UniGene: Hs.584775