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  4. Human macrophage stimulating protein,MSP ELISA Kit

Human macrophage stimulating protein,MSP ELISA Kit

  • 中文名称：
    人巨噬细胞刺激蛋白(MSP)酶联免疫试剂盒
  • 货号：
    CSB-E09062h
  • 规格：
    96T/48T
  • 价格：
    ￥3200/￥2500
  • 其他：

产品详情

  • 产品描述：
        MST1 (macrophage stimulating 1)：是一种细胞因子，参与多种生物学过程。MST1主要发挥免疫调节和组织修复的作用，可以促进巨噬细胞的分化和活化，参与炎症反应和创伤修复。此外，MST1还可以调节血管生成和细胞凋亡等生物学过程。
        j9九游会登录入口首页生物所提供的Human macrophage stimulating protein,MSP ELISA Kit属于ELISA检测试剂盒，采用双抗夹心法定量检测人血清、血浆、组织匀浆样本中的MST1，其灵敏度为0.039 ng/mL，检测范围为0.156 ng/mL-10 ng/mL。
     
  • 别名：
    D3F15S2 ELISA Kit; DNF15S2 ELISA Kit; Hepatocyte growth factor like protein alpha chain ELISA Kit; Hepatocyte growth factor like protein ELISA Kit; Hepatocyte growth factor like protein beta chain ELISA Kit; Hepatocyte growth factor like protein homolog ELISA Kit; Hepatocyte growth factor-like protein beta chain ELISA Kit; HGFL ELISA Kit; HGFL_HUMAN ELISA Kit; Macrophage stimulating 1 (hepatocyte growth factor like) ELISA Kit; Macrophage stimulatory protein ELISA Kit; Macrophage-stimulating protein ELISA Kit; MSP ELISA Kit; MST1 ELISA Kit; NF15S2 ELISA Kit; OTTHUMP00000208927 ELISA Kit
  • 缩写：
    MST1
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    0.156 ng/mL-10 ng/mL
  • 灵敏度：
    0.039 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
    MST1，全名为肌肉特异性蛋白激酶1，是一种重要的信号转导蛋白。最近的研究表明，MST1参与了多种疾病的发生和发展，包括肿瘤、心血管疾病和神经退行性疾病等。MST1还与炎症、自噬和细胞凋亡等生物学过程相关。
  • 基因功能参考文献：
    1. Mst1 has an important role in inhibiting the growth of NSCLC in vitro and in vivo; its antiproliferative effect is associated with induction of apoptosis. PMID: 23928732
    2. These data suggest that MSP is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP has a key regulatory role in non-alcoholic steatohepatitis. PMID: 27609031
    3. Identify MST1/MSP as a mitogen for tracheal basal cells. PMID: 25551685
    4. MSP appears to promote the migration of fibroblasts, enhances collagen synthesis and remodeling, and effectively improves wound healing. PMID: 25315688
    5. Elevated serum levels of MST1 were found in subjects with excessive alcohol use. PMID: 25704570
    6. These results support the hypothesis that the alpha-chain of MSPalphabeta mediates RON dimerization. PMID: 25193665
    7. functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele PMID: 24409221
    8. Results suggest that the [AA] genotype of the common MST1 variant rs3197999 enhances genetic risk of sporadic extrahepatic cholangiocarcinoma irrespective of primary sclerosing cholangitis status. PMID: 23422030
    9. MSP may be one of the major determinants that affects the properties of tumor stroma and that produces a permissive microenvironment to promote cancer metastasis PMID: 23011677
    10. The present results refine the known genetic architecture in primary sclerosing cholangitis by confirming MST1 locus association. PMID: 22554193
    11. the missense SNP impairs MSP function by reducing its affinity to RON and perhaps through a secondary effect on in vivo concentration arising from reduced thermodynamic stability, resulting in down-regulation of the MSP/RON signaling pathway. PMID: 22087277
    12. HAT cleaves proMSP at the physiological activation site PMID: 22245154
    13. Studies indicate that the cylindromatosis/turban tumor syndrome gene (CYLD) ranked highest, followed by acylaminoacyl-peptidase (APEH), dystroglycan (DAG1), macrophage-stimulating protein (MST1) and ubiquitin-specific peptidase 4 (USP4). PMID: 21931648
    14. These findings suggest that the MSP/RON signaling pathway may be regulated by hepsin in tissue homeostasis and in disease pathologies, such as in cancer and immune disorders. PMID: 21875933
    15. considerable number of Merkel cell carcinoma cases expressed both RON and MSP, while Merkel cells do not express these molecules PMID: 21723047
    16. MSP-induced RSK2 activation is a critical determinant linking RON signaling to cellular EMT program. PMID: 21619683
    17. the oncogenic effect of BRAF(V600E) is associated with the inhibition of MST1 tumor suppressor pathways, and that the activity of RASSF1A-MST1-FoxO3 pathways determines the phenotypes of BRAF(V600E) tumors. PMID: 21249150
    18. results suggest that MSP induces uPAR expression via MAPK, AP-1 and NF-kappaB signaling pathways PMID: 21081472
    19. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20014019
    20. These results suggest that activation of RON by macrophage-stimulating protein inhibits LPS-induced macrophage Cox-2 expression. PMID: 12177064
    21. Data show that macrophage stimulating protein (MSP) and its receptor (Ron) induce phosphorylation of both Ron and alpha6beta4 integrin, and result in activation of alpha3beta1 integrin. PMID: 12919677
    22. macrophage-stimulating protein-responsive cell growth in culture is suppressed by the ron-sema domain PMID: 14597639
    23. Macrophage stimulating protein and its receptor RON are involved in the pathophysiology of endometriosis. PMID: 15764806
    24. repression of MSP gene expression by mutant p53 may contribute to oncogenesis in a cell type-specific manner PMID: 16170349
    25. overexpression of MSP, MT-SP1, and MST1R was a strong independent indicator of both metastasis and death in human breast cancer PMID: 17456594
    26. Cell migration and production of inflammatory cytokines by the brain are enhanced by MSP stimulation in primary microglia. PMID: 18480548
    27. The five gene transcripts (aldolase B, elafin, MST-1, simNIPhom and SLC6A14) were changed in patients with ulcerative colitis, and were related to the disease activity. PMID: 18700007
    28. Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis. PMID: 19079170
    29. Results suggest that hepatocyte growth factor activator is a major serum activator of pro-macrophage-stimulating protein. PMID: 19456860
    30. The effect of BSN-MST1 locus on Crohn's disease predisposition was replicated, but no influence on ulcerative colitis or multiple sclerosis predisposition could be detected PMID: 19657358

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  • 相关疾病：
    MST1 variant Cys-689 may be associated with inflammatory bowel disease (IBD), a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is unsure whether Cys-689 itself or a variation in linkage disequilibrium with Cys-689 is responsible for the association with IBD.
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family, Plasminogen subfamily
  • 数据库链接：

    HGNC: 7380

    OMIM: 142408

    KEGG: hsa:4485

    STRING: 9606.ENSP00000414287

    UniGene: Hs.349110