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Human neuregulin-2 (NRG2) ELISA kit

  • 中文名称：
    人神经调节蛋白2(NRG2)酶联免疫试剂盒
  • 货号：
    CSB-EL016078HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Human NRG2 ELISA Kit was designed for the quantitative measurement of Human NRG2 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 31.25 pg/mL-2000 pg/mL and the sensitivity is 7.81 pg/mL.

  • 别名：
    Divergent of neuregulin 1 ELISA Kit; Divergent of neuregulin-1 ELISA Kit; Don 1 ELISA Kit; DON-1 ELISA Kit; Neural- and thymus-derived activator for ERBB kinases ELISA Kit; Neuregulin 2 ELISA Kit; Neuregulin-2 ELISA Kit; NRG-2 ELISA Kit; Nrg2 ELISA Kit; NRG2_HUMAN ELISA Kit; NTAK ELISA Kit; Pro NRG2 ELISA Kit; Pro-NRG2 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    31.25 pg/mL-2000 pg/mL
  • 灵敏度：
    7.81 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Neuroscience
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human NRG2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:5 Average % 101
    Range % 88-105
    1:10 Average % 100
    Range % 90-105
    1:20 Average % 97
    Range % 88-101
    1:40 Average % 99
    Range % 94-102
  • 回收率：
    The recovery of human NRG2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 94 87-97
    EDTA plasma (n=4) 101 95-107
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    2000 2.638 2.567 2.603 2.404
    1000 2.312 2.222 2.267 2.068
    500 1.722 1.787 1.755 1.556
    250 1.156 1.129 1.143 0.944
    125 0.702 0.684 0.693 0.494
    62.5 0.501 0.513 0.507 0.308
    31.25 0.326 0.338 0.332 0.133
    0 0.201 0.197 0.199 　
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
  • 基因功能参考文献：
    1. reduced expression of NRG2 led to marginal increase in cell survival under arsenite-induced stress. PMID: 27345716
    2. examination of the effect of isoforms on angiogenesis PMID: 14722120
    3. Nrg-2-induced Acetylcholine Receptor transcription requires an N-box motif and is regulated by alternative splicing. PMID: 15961242
    4. Linkage interval for GLC1M was refined to a smaller region. The NRG2 gene was excluded as the causative gene for juvenile-onset primary open angle glaucoma. PMID: 17563728
    5. Gln43 of NRG2beta is both necessary and sufficient for NRG2 stimulation of ErbB4 coupling to IL3 independence. PMID: 17945187
    6. NRG2 was positive in almost all breast cancers studied. High expression is related to the biological aggressiveness of breast cancer. PMID: 17962208

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  • 亚细胞定位：
    [Pro-neuregulin-2, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-2]: Secreted.
  • 蛋白家族：
    Neuregulin family
  • 组织特异性：
    Restricted to the cerebellum in the adult.
  • 数据库链接：

    HGNC: 7998

    OMIM: 603818

    KEGG: hsa:9542

    STRING: 9606.ENSP00000354910

    UniGene: Hs.408515