Your Good Partner in Biology Research

  1. 首页
  2. 试剂盒
  3. 酶联免疫试剂盒
  4. Human orosomucoid 2,ORM2 ELISA Kit

Human orosomucoid 2,ORM2 ELISA Kit

  • 中文名称：
    人类粘蛋白2(ORM2)酶联免疫试剂盒
  • 货号：
    CSB-E11821h
  • 规格：
    96T/48T
  • 价格：
    ￥3200/￥2500
  • 其他：

产品详情

  • 产品描述：
        ORM2（orosomucoid 2）是一种血清糖蛋白，通常由肝脏合成。ORM2可以调节和减少细胞因子和白细胞趋化因子的作用。ORM2的含量在肝脏疾病、炎症和感染时常常会发生变化，因此可以作为这些疾病的生物标志物。
        j9九游会登录入口首页生物所提供的Human orosomucoid 2,ORM2 ELISA Kit属于ELISA检测试剂盒，采用竞争法定量检测人血清、血浆、组织匀浆样本中的ORM2，其灵敏度为19.5 ng/mL，检测范围为78 ng/mL-5000 ng/mL。
     
  • 别名：
    ORM2 ELISA Kit; AGP2Alpha-1-acid glycoprotein 2 ELISA Kit; AGP 2 ELISA Kit; Orosomucoid-2 ELISA Kit; OMD 2 ELISA Kit
  • 缩写：
    ORM2
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    78 ng/mL-5000 ng/mL
  • 灵敏度：
    19.5 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cardiovascular
  • 测定原理：
    quantitative
  • 测定方法：
    Competitive
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human ORM2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:100 Average % 98  
    Range % 90-102  
    1:200 Average % 89  
    Range % 83-94  
    1:400 Average % 101  
    Range % 93-105  
    1:800 Average % 105  
    Range % 97-110  
  • 回收率：
    The recovery of human ORM2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 90 82-95  
    EDTA plasma (n=4) 94 90-98  
                 
                 
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average    
    5000 0.131 0.135 0.133    
    2500 0.389 0.401 0.395    
    1250 0.750 0.732 0.741    
    625 1.042 1.020 1.031    
    312 1.441 1.454 1.448    
    156 1.650 1.666 1.658    
    78 1.806 1.767 1.787    
    0 2.001 2.078 2.040    
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
    ORM2，全称为酸性糖蛋白，是一种血浆蛋白。最近的研究表明，ORM2在多种疾病中发挥着重要作用，包括炎症、心血管疾病和肝病等。ORM2参与了细胞凋亡、免疫反应和糖代谢等生物学过程。
  • 功能：
    Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
  • 基因功能参考文献：
    1. the glycosylation change of alpha-1-acid glycoprotein (AGP) in hepatocellular carcinoma (HCC), cirrhosis and controls PMID: 28621608
    2. Neural cell interactions are important for brain physiology and pathology. Particularly, the interaction between non-neuronal cells plays a central role in regulating brain inflammation, which is closely linked to many brain disorders. Here, we newly identified orosomucoid-2 (ORM2) as an endogenous protein that mediates such non-neuronal glial cell interactions PMID: 28193696
    3. Low ORM2 expression is associated with metastasis in hepatocellular carcinoma. PMID: 25965830
    4. Data suggest that human serum albumin (HSA) might serve as a carrier in delivering chitooligomers to target tissues than alpha-1-glycoprotein (AGP) which has pharmacological importance. PMID: 24359035
    5. Alteration in expression of ORM2 suggests that ORM2 could be used as a potential biomarker in the diagnosis of colorectal cancer. PMID: 22363757
    6. the sera of patients with acute inflammation demonstrated increased numbers of bi-antennary and alpha1,3-fucosylated N-glycan structures at each glycosylation site PMID: 15863355
    7. The binding of coumarin enantiomers to ORM2 is studied. PMID: 16290938
    8. Results describe the thermal unfolding and reversibility of temperature-induced changes in alpha(1)-acid glycoprotein. PMID: 16331959
    9. The results indicate that, in accordance with prior expectations, the ORM2 variant is responsible for the acute-phase property of alpha-1 acid glycoprotein. PMID: 19018521
    10. structure of the alpha1-acid glycoprotein (AGP), or orosomucoid (ORM), gene was investigated in a Ghanaian mother and her child, who shared an unusual variant, ORM1 S2(C), found by isoelectric focusing PMID: 11587070

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Calycin superfamily, Lipocalin family
  • 组织特异性：
    Expressed by the liver and secreted in plasma.
  • 数据库链接：

    HGNC: 8499

    OMIM: 138610

    KEGG: hsa:5005

    STRING: 9606.ENSP00000394936

    UniGene: Hs.719954