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  4. Human tissue inhibitors of metalloproteinase 4,TIMP-4 ELISA Kit

Human tissue inhibitors of metalloproteinase 4,TIMP-4 ELISA Kit

  • 中文名称：
    人基质金属蛋白酶抑制因子4(TIMP-4)酶联免疫试剂盒
  • 货号：
    CSB-E04735h
  • 规格：
    96T/48T
  • 价格：
    ￥3200/￥2500
  • 其他：

产品详情

  • 产品描述：
        组织抑制金属蛋白酶（TIMP）是一类可以抑制金属蛋白酶活性的蛋白质，包括TIMP1-4，其中TIMP4在人体中分布较广，主要分布于心血管和肌肉组织。研究表明，TIMP4能够通过调控基质金属蛋白酶的活性，参与多种生理和病理过程，如组织再生、肿瘤发生和心血管疾病等。在心血管疾病中，TIMP4可作为一种保护性分子，通过抑制心肌细胞凋亡和心肌纤维化等途径来保护心脏免受损害。
        j9九游会登录入口首页生物所提供的Human tissue inhibitors of metalloproteinase 4,TIMP-4 ELISA Kit属于ELISA检测试剂盒，采用双抗夹心法定量检测人血清、血浆、组织匀浆、乳汁样本中的TIMP4，其灵敏度为0.005 ng/mL，检测范围为0.313 ng/mL-20 ng/mL。
     
  • 别名：
    Metalloproteinase inhibitor 4 ELISA Kit; TIMP 4 ELISA Kit; TIMP metallopeptidase inhibitor 4 ELISA Kit; TIMP-4 ELISA Kit; Timp4 ELISA Kit; TIMP4_HUMAN ELISA Kit; Tissue inhibitor of metalloproteinase 4 ELISA Kit; Tissue inhibitor of metalloproteinases 4 ELISA Kit
  • 缩写：
    TIMP4
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates, human milk
  • 检测范围：
    0.313 ng/mL-20 ng/mL
  • 灵敏度：
    0.005 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cardiovascular
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
    TIMP4，全称为组织抑制金属蛋白酶4（tissue inhibitor of metalloproteinases 4），是一种重要的金属蛋白酶抑制剂。最新的研究表明，TIMP4可能在多种生理和病理过程中起到关键作用，包括心血管疾病、肿瘤、肝病和神经退行性疾病等。研究者们正在努力深入研究TIMP4的作用机制，以期为相关疾病的治疗提供新的靶点和策略。
  • 功能：
    Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
  • 基因功能参考文献：
    1. MMP2/TIMP4 ratio is a marker of disease severity and right ventricular function as well as a predictor for survival and time to clinical worsening in idiopathic pulmonary arterial hypertension. PMID: 28516393
    2. Aspirin-HPR did not affect the translocation and release of MMPs and TIMP-4 from platelets. PMID: 28770228
    3. Combining two biomarkers significantly improved discrimination of AHRE. CONCLUSION: TIMP-4, NT-proANP, NT-proBNP were strongest associated with PAF and AHRE. The discriminatory performance of CHADS2-VASc for PAF was increased by addition of selected biomarkers. PMID: 28431065
    4. Our findings provide new evidence that LOX regulates SNAI2 expression and that SNAI2-mediated TIMP4 secretion plays a role in cancer progression. PMID: 27029493
    5. This report provides the first example that TIMP-4 regulates carcinogenesis through enriching the tumor progenitor cell population in cervical cancer cells. PMID: 26618609
    6. Concluding, miR-200b-3p mediates regulation of TIMP4 expression in prostate cancer but exact mechanism needs to be investigated. PMID: 28028835
    7. regulates carcinogenesis through apoptosis activation in cervical cancer cells PMID: 26291714
    8. Upregulation of plasma TIMP-4 might contribute to PIH [pregnancy-induced hypertension] processes PMID: 25986893
    9. This study provides evidence that the promoter TIMP4 rs3755724 is a new focal epilepsy susceptibility variant that is plausibly involved in inflammation-induced seizures in Malaysian Chinese. PMID: 25595263
    10. Selective myocardial targeting for TIMP-4 induction through either a viral or transgenic approach favorably altered the course of adverse left ventricular remodeling post-myocardial infarction. PMID: 24637197
    11. The rs3755724 in TIMP4 protein was nominally associated with schizophrenia with poor concentration. PMID: 23229788
    12. Heterogeneous methylation in the promoter region of TIMP4 was associated with cancer progression in non-small cell lung cancer. PMID: 22018271
    13. A trend toward increased serum levels of MMP-9/TIMP-4 was found in patients with successful arteriovenous fistulas. PMID: 21620625
    14. Plasma TIMP-4 has a role in the prediction of LV remodeling and the pathophysiology of the heart postinfarction PMID: 21624734
    15. MMP-10 and -7 abundance increased, accompanied by decreased TIMP-4 in dilated cardiomyopathy failing hearts compared with non-failing hearts. PMID: 20219015
    16. TIMP4 expression is a downstream target of GCM1 PMID: 21406447
    17. Expressions of MMP1, MMP9, TIMP4, and EMMPRIN were significantly unbalanced in the myocardium of congestive heart failure patients with rheumatic heart diseases. PMID: 19734590
    18. this work provides the first evidence of a TIMP-4/CD63 association in astrocytoma tumor cells PMID: 20693981
    19. TIMP-4 overexpression is associated with joint tissue remodeling and pathogenesis of osteoarthritic cartilage PMID: 11948685
    20. TIMP-4 is the major intraplatelet matrix metalloproteinase inhibitor and it is involved in regulation of platelet aggregation and recruitment. PMID: 12466243
    21. Progress curve analysis of MMP inhibition by TIMP-4 indicates that association rate constants and inhibition constants are similar to those for other TIMPs; TIMP-4 has a 5-fold lower binding affinity for proMMP-2 than does TIMP-2. PMID: 12475252
    22. Results suggest a functional relationship between TIMP-4 mRNA and MMP-26 mRNA, and possibly a role in human implantation. PMID: 15273280
    23. TIMP-4 displayed negligible activity against TACE, N-TIMP-4 is a slow tight-binding inhibitor with low nanomolar binding affinity PMID: 15713681
    24. TIMP-4 is expressed de novo in cervical cancer PMID: 15816637
    25. In conclusion, the data demonstrate upregulation of TIMP4 in human cardiovascular disorders exhibiting inflammation, suggesting its future use as a novel systemic marker for vascular inflammation. PMID: 16521002
    26. Maximal expression of TIMP-4 in the early and mid-secretory phase suggests its role during implantation and results show that TIMP-4 control the the relaese of MMP-26 in both stroma and uterine fluid. PMID: 16809379
    27. Results indicate that MMP-26 and TIMP-4 may play an integral role during the conversion of high-grade prostatic intraepithelial neoplasia to invasive cancer and may also serve as markers for early prostate cancer diagnosis. PMID: 16940965
    28. Enzyme immunoassays showed the levels of type 4 tissue inhibitor of metalloproteinases were virtually the same in colorectal cancer and mucosa. PMID: 18214300
    29. C/T polymorphism which is located on the 3'-untranslational regions of the TIMP-4 gene might be associated with susceptibility to Osteoarthritis in a Korean population PMID: 18301898
    30. Peroxynitrite-induced nitration and oligomerization of TIMP-4 attenuated its inhibitory activity against MMP-2 activity and endothelial or tumor cell invasiveness. PMID: 18336787
    31. TIMP4 is related to the development of KD with CALs in Korean children. PMID: 19048177
    32. a cardiopulmonary vasculature-specific role of TIMP-4 activation in systemic sclerosis. PMID: 19190762
    33. MMP-3 and TIMP-4 polymorphisms affect angiographic coronary plaque progression in type 2 diabetic and non-diabetic patients PMID: 19376102
    34. TIMP-4 as a simple prognostic marker that may help identify patients with early-stage breast cancer who could benefit from more aggressive treatment at diagnosis PMID: 19700750

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Protease inhibitor I35 (TIMP) family
  • 组织特异性：
    Abundant in heart and present at low levels in many other tissues.
  • 数据库链接：

    HGNC: 11823

    OMIM: 601915

    KEGG: hsa:7079

    STRING: 9606.ENSP00000287814

    UniGene: Hs.591665