Mouse Angiotensin converting enzyme 2(ACE2)ELISA Kit

Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. By cleavage of angiotensin II, may be an important regulator of heart function. By cleavage of angiotensin II, may also have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19, regulating its trafficking on the cell surface and its activity.

1. ACE2/A1-7/Mas axis may be one of the intra-islet paracrine mechanisms of communication between alpha and beta cells. Enhancing the ACE2/A1-7 axis exerts a protective effect by ameliorating beta cell dedifferentiation. PMID: 29225087
2. ACE2 is a novel factor required for exercise-dependent modulation of adult neurogenesis and essential for serotonin metabolism. PMID: 29679094
3. High ACE2 expression is associated with acute lung injury. PMID: 29990483
4. These results were supported by the opposite outcomes observed for cells treated with A779 or DX600. Therefore, it was concluded that the ACE2-Ang(17)-Mas axis significantly inhibits pancreatitis by inhibition of the p38 MAPK/NF-kappaB signaling pathway PMID: 29138810
5. Exogenous ACE2 alters angiotensin peptide metabolism in the kidneys of Col4a3 knockout mice and attenuates the progression of Alport syndrome nephropathy. PMID: 28249676
6. Profound augmentation of ACE2 confined to the circulation failed to ameliorate the glomerular lesions and hyperfiltration characteristic of early diabetic nephropathy. PMID: 27927599
7. Nrf2-mediated stimulation of intrarenal Renin-Angiotensin syste, (CAE2 and MasR) gene expression, by which chronic hyperglycemia induces hypertension and renal injury in diabetes. PMID: 29211853
8. In islets from db/db mice, ACE2 over-expression increased intracellular calcium influx and restored impaired mitochondrial oxidation, potentially causing an increase in GSIS. These results shed light on the potential roles of ACE2 in mitochondrial metabolism, moreover, may improve our understanding of diabetes. PMID: 29128354
9. Ultra-high doses did not influence the ACE2/AT2R/Mas axis and promoted renal injury with increased renal ERK1/2 activation and exaggerated fibronectin expression in db/db mice. Our study demonstrates dose-related effects of candesartan in diabetic nephropathy: intermediate-high dose candesartan is renoprotective, whereas ultra-high dose candesartan induces renal damage. PMID: 27612496
10. Altogether, our study demonstrates that HFD feeding increases RAS activity and mediates glycemic dysregulation likely through loss of ACE2 present outside the islets but independently of changes in islet ACE2. PMID: 27806985
11. Results suggest that angiotensin converting enzyme 2 may reduce anxiety-like behavior by activating central Mas receptor that facilitate GABA release onto pyramidal neurons within the basolateral amygdala. PMID: 26767952
12. These findings demonstrate that ACE2 plays a critical role in preventing RSV-induced lung injury, and suggest that ACE2 is a promising potential therapeutic target in the management of RSV-induced lung disease. PMID: 26813885
13. ACE2 overexpression significantly reduced the myocardial infarction-induced increase in apoptosis, macrophage infiltration, and HMGB1 and proinflammatory cytokine expression. PMID: 26498282
14. ACE2 regulates vascular function by modulating nitric oxide release. PMID: 27070147
15. MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2-angiotensin-(1-7)-MAS axis functionality PMID: 26144375
16. ACE2 plays a novel role in heart disease associated with obesity wherein ACE2 negatively regulates obesity-induced epicardial adipose tissue inflammation and cardiac insulin resistance. PMID: 26224885
17. a Mas receptor-mediated mechanism may stimulate pancreatic cell development PMID: 26029927
18. ACE2 deficiency exacerbates kidney inflammation, oxidative stress and adverse renal injury in the ApoE-mutant mice through modulation of the nephrin, NOX4 and TNF-alpha-TNFRSF1A signaling. PMID: 26245758
19. Hydronephrosis led to an increase of ACE level and a decrease of ACE2 and Mas receptor in the heart. PMID: 25650385
20. Overexpression of ADAM17 increases shed ACE2 and decreases cellular ACE2 levels in pancreatic islets. Whereas ADAM17 has the ability to shed ACE2, ADAM17 does not deplete ACE2 from pancreatic islets in diabetic db/db mice. PMID: 26441236
21. ACE2 and Ang-(1-7) significantly inhibit early atherosclerotic lesion formation via protection of endothelial function and inhibition of inflammatory response. PMID: 25721616
22. These results demonstrate a critical role for endogenous ACE2 in the adaptive beta-cell hyperinsulinemic response to High Fat feeding through regulation of beta-cell proliferation and growth. PMID: 26389599
23. ACE2 deficiency worsened the influenza pathogenesis markedly, mainly by targeting the angiotensin II type 1 receptor (AT1). PMID: 25391767
24. Placental hypoxia and uterine artery dysfunction develop before major growth of the fetus occurs and may explain the fetal growth restricted phenotype in Ace2 knock-out pregnant mice. PMID: 25968580
25. Beneficial effects of E2 to decrease blood pressure in ovariectomized obese females may result from stimulation of adipose ACE2. PMID: 26078188
26. In experimental mouse models, infection with highly pathogenic avian influenza A H5N1 virus results in downregulation of angiotensin-converting enzyme 2 (ACE2) expression in the lung and increased serum angiotensin II levels. PMID: 24800825
27. Whole-body deficiency of ACE2 significantly increased aortic lumen diameters and external diameters of suprarenal aortas from AngII-infused mice. PMID: 25301841
28. Brain-targeted angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation. PMID: 25489058
29. Partial loss of ACE2 is sufficient to enhance the susceptibility to heart disease. PMID: 24728465
30. Suggest that the ACE2-ACE imbalance plays an important role in the pathogenesis of severe acute pancreatitis and that pancreatic ACE2 is an important factor in determining the severity of SAP. PMID: 24414175
31. Expression of ACE2 reduced the fibrosis. PMID: 24695436
32. Angiotensin converting enzyme 2/Ang-(1-7)/Mas axis protects brain from ischemic injury via the Nox/ROS signaling pathway, with a greater effect in older mice PMID: 24581232
33. ACE2 deficiency promotes the development of vascular diseases associated with Ang-II-mediated vascular inflammation and activation of the JNK signalling, leading to the notion that ACE2 potentially confers protection against vascular diseases. PMID: 24193738
34. Proximal tubular shedding of ACE2 may increase in diabetes. PMID: 24454948
35. This study also shows that serum and urine ACE2 activity is increased in the NOD mouse model of diabetes starting at an early stage of the disease. PMID: 24400109
36. Loss of ACE2 exacerbates AngII-mediated inflammation, myocardial injury and dysfunction in ACE2-deficient hearts via activation of the CTGF-FKN-ERK and MMP signaling. PMID: 24161906
37. Suggest that ACE2 plays a key role in the recruitment of the renal reserve and hyperfiltration associated with diabetes. PMID: 24477684
38. blockade of the AT1 receptor by azilsartan could enhance the activities of the ACE2/Ang-(1-7)/Mas axis and ACE2/Ang-(1-7)/AT2 receptor axis, thereby inhibiting neointimal formation. PMID: 24379178
39. These results suggest that ACE2 plays an important role in postnatal development of the heart, and that lack of ACE2 enhances coronary artery remodeling with an increase in perivascular fibrosis and cardiac hypertrophy already around the weaning period. PMID: 23608725
40. ACE2 has a protective role in murine renal ischemia-reperfusion injury. PMID: 23951161
41. ACE2 was downregulated in apelin-deficient mice. Apelin, via activation of its receptor, APJ, increased ACE2 promoter activity in vitro and upregulated ACE2 expression in failing hearts in vivo. ACE2 couples the RAS to the apelin system. PMID: 24177423
42. Unlike angiotensin-converting enzyme 2, collectrin lacks any catalytic domain. PMID: 24048198
43. Urinary ACE2 could be a potential biomarker of increased metabolism of ANG II in diabetic kidney disease. PMID: 23761674
44. A cardioprotective and vascular protective role is documented for ACE2 under pathological conditions. PMID: 23043153
45. This review summarizes and discusses the structure and multiple functions of ACE2 and the relevance of this key enzyme in disease pathogenesis. PMID: 23328447
46. ACE2 metabolizes ANG II in the kidney at neutral and basic pH, while prolylcarboxypeptidase catalyzes the same reaction at acidic pH. PMID: 23392115
47. Upregulation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in the heart and the kidney of growth hormone receptor knock-out mice PMID: 22947377
48. Severe acute pancreatitis is associated with upregulation of the ACE2-angiotensin-(1-7)-Mas axis and promotes increased circulating angiotensin-(1-7). PMID: 23127535
49. ACE2 protects against high-calorie diet-induced insulin resistance in mice. This mechanism may involve the transcriptional regulation of GLUT4 via an A1-7-dependent pathway. PMID: 22933108
50. ACE2 deficiency impaired endothelial function in cerebral arteries from adult mice and augmented endothelial dysfunction during aging. PMID: 23160880

显示更多

收起更多

[Processed angiotensin-converting enzyme 2]: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell projection, cilium. Apical cell membrane.

Expressed in heart, kidney and forebrain (at protein level). Expressed in the small intestine, with expression in the intestinal brush border (at protein level). Ubiquitously expressed, with highest levels in ileum, kidney and lung. In lung, expressed on

KEGG: mmu:70008

STRING: 10090.ENSMUSP00000073626

UniGene: Mm.13451