Your Good Partner in Biology Research

  1. 首页
  2. 试剂盒
  3. 酶联免疫试剂盒
  4. Mouse Apolipoprotein D(APOD) ELISA kit

Mouse Apolipoprotein D(APOD) ELISA kit

  • 中文名称：
    小鼠载脂蛋白D(APOD)酶联免疫试剂盒
  • 货号：
    CSB-EL001935MO
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 别名：
    ApodApolipoprotein D ELISA kit; Apo-D ELISA kit; ApoD ELISA kit
  • 缩写：
    APOD
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 样本类型：
    serum, plasma, urine
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Signal Transduction
  • 精密度：
     
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse APOD in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:1000 Average % 97  
    Range % 92-106  
    1:2000 Average % 90  
    Range % 83-99  
    1:4000 Average % 89  
    Range % 86-99  
    1:8000 Average % 92  
    Range % 87-102  
  • 回收率：
     
  • 标准曲线：
     
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
  • 基因功能参考文献：
    1. Study shows that in myelin maturation ApoD ultimately controls the removal of the sialic-rich hydrophilic glycocalyx, by maintaining functional integrity of lysosomes. A detailed analysis of the mechanism reveals that the proper localization of Neu1 and plasma membrane Neu3, as well as of the membrane-bound Fyn kinase, depend on ApoD. PMID: 29222871
    2. apoD protein levels are variable across different brain regions. PMID: 26829325
    3. It regulates amyloid plaque pathology in a mouse model of Alzheimer's disease PMID: 25784209
    4. apoD may be part of an intrinsic cardioprotective system, possibly as a consequence of its antioxidation activity. PMID: 24082102
    5. Changes in hypothalamus of ApoD(-/-) mice may indicate potential role of ApoD in regulation of endocrine functions of somatostatin in a receptor-dependent manner. PMID: 22581439
    6. Abeta25-35 induces neuroprotective ApoD expression in hippocampal cells in response to stress-induced growth arrest. PMID: 22398376
    7. The findings underscore the importance of ApoD in the regulation of plasma insulin levels and triglyceride metabolism, suggesting that ApoD plays an important role in the pathogenesis of dyslipidemia. PMID: 21632073
    8. The data of this study supported that ApoD contributes to the endurance of astrocytes and decreases their reactivity level in vitro and in vivo PMID: 21688324
    9. Scanning cytometry revealed PACAP/ApoD induced low density lipoprotein receptors (LDLR) and ApoE receptor 2 (apoER2) in NF200-positive cells. PMID: 20920539
    10. mRNA and protein expression profiles reveal that ApoD is functionally connected in an age-dependent manner to specific molecular programs triggered by injury. PMID: 20607718
    11. Apolipoprotein D plays a significant role in lipid metabolism. PMID: 20124557
    12. This study concluded that glutamatergic pathways seem to be particularly affected in ApoD(-/-) mice. PMID: 19963028
    13. Expression pattern of the lipocalin apolipoprotein D during mouse embryogenesis. PMID: 11744388
    14. Apolipoprotein D-immunolabeled cells are observed in select grey matter nuclei, including the globus pallidus, thalamus, and substantia nigra, and in white matter tracts within the internal capsule and cerebellum of Neimann-Pick type C mouse brain. PMID: 12815234
    15. apolipoprotein D and the lipogenic protein Spot 14 are LXR alpha and LXRB responsive genes both in vitro and in vivo PMID: 14703507
    16. ApoD messenger RNA expression was localised to the spiral ligament and spiral limbus, particularly in the suprastrial and supralimbral regions. PMID: 15668042
    17. These observations, together with its transcriptional up-regulation in the brain upon oxidative insult, identify ApoD as an acute response protein with a protective and therefore beneficial function mediated by the control of peroxidated lipids. PMID: 18419796
    18. Taken together, our results describe receptor and region specific changes in SST and SSTR subtypes expression in ApoD(-/-) mice brain, which may be linked to specific neurological disorders. PMID: 19465111

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Calycin superfamily, Lipocalin family
  • 组织特异性：
    Highest levels of expression in brain, testis, virgin mammary gland and salivary gland. Moderate levels in skeletal muscle, lactating mammary gland and thymus. Low levels in lung and lymph node. No expression in kidney, pancreas, liver or spleen.
  • 数据库链接：

    KEGG: mmu:11815

    STRING: 10090.ENSMUSP00000110885

    UniGene: Mm.2082