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  4. Mouse CD48 antigen(CD48) ELISA kit

Mouse CD48 antigen(CD48) ELISA kit

  • 中文名称：
    小鼠CD48抗原(CD48)酶联免疫试剂盒
  • 货号：
    CSB-EL004941MO
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This mouse CD48 ELISA kit employs the quantitative sandwich enzyme immunoassay technique to measure the levels of mouse CD48 in multiple samples, including serum, plasma, or tissue homogenates. It also uses the enzyme-substrate chromogenic reaction to visualize and analyze the analyte levels through the color intensity. The intensity of the colored product is in direct proportion to the CD48 levels in the sample and is measured at 450 nm through a microplate reader.

    CD48 is an adhesion and costimulatory molecule expressed constitutively on nearly all hematopoietic cells. It is involved in cell adhesion and costimulation, activation of immune cells, regulation of target cell lysis by cytolytic cells, as well as detection of microbes through its interaction with the bacterial component FimH. Through interactions with CD2, CD48 contributes to synapse organization between T cells and antigen-presenting cells (APCs) and can enhance TCR signaling. CD48 mediates interactions with T cells, B cells, and NK cells by binding to CD244. CD48 cross-linking on human eosinophils triggers the release of eosinophil granule proteins, cytokines, and chemokines.

  • 别名：
    Cd48 ELISA kit; Bcm-1CD48 antigen ELISA kit; BCM1 surface antigen ELISA kit; BLAST-1 ELISA kit; HM48-1 ELISA kit; MRC OX-45 surface antigen ELISA kit; SLAM family member 2 ELISA kit; SLAMF2 ELISA kit; Signaling lymphocytic activation molecule 2 ELISA kit; sgp-60 ELISA kit; CD antigen CD48 ELISA kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 检测范围：
    Request Information
  • 灵敏度：
    Request Information
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.
  • 基因功能参考文献：
    1. Molecular dynamic simulation explains unbinding and unfolding of CD48-2B4 protein complexes. PMID: 25142868
    2. These data demonstrate the important role of CD48 in SA/exotoxins-eosinophil activating interactions that can take place during allergic responses and indicate CD48 as a novel therapeutic target for allergy and especially of AD. PMID: 25255823
    3. ORMDL3 promotes eosinophil trafficking and activation via regulation of CD18, CD49d, and CD48. PMID: 24056518
    4. Ox-LDL significantly promoted the interaction of natural killer cells and dendritic cells via CD48-2B4 contact-dependent mechanisms. PMID: 21221603
    5. B6-specific background genes modulate the effect of CD48 on lupus nephritis in a recessive manner PMID: 21561736
    6. CD48 plays a vital role as an environmental sensor for regulating hematopoietic stem cells and progenitor cell numbers and inhibiting tumor development PMID: 21576698
    7. CD48 on surrounding NK or non-NK cells serves primarily as a ligand to stimulate 2B4 on the adjacent NK cells in mice PMID: 20647560
    8. CD48 interactions with NK cell receptor 2B4 among neighboring T cells during T cell priming augment CTL lysis of their specific targets. PMID: 12734329
    9. compare the relative contributions of MHC class I and CD48 to NK cell self-tolerance; and CD244 regulates NK cell tolerance to normal cells in vivo; evidence for MHC-independent NK self-recognition in a bone marrow rejection assay PMID: 15870174
    10. Cell surface receptors of the SLAM family, including CD150, CD244, and CD48, were differentially expressed among functionally distinct hematopoietic progenitor cells. PMID: 15989959
    11. Review of recent studies suggests an important role for interactions between 2B4 and CD48 in the course of T cell activation and proliferation PMID: 16081768
    12. T cell-induced experimental colitis is ameliorated only when CD48 is absent from both T cells and antigen-presenting cells. PMID: 16472597
    13. the mechanism of signal transduction by CD244 is to regulate FYN kinase recruitment and/or activity and the outcome of CD48/CD244 interactions is determined by which other receptors are engaged. PMID: 17599905

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 数据库链接：

    KEGG: mmu:12506

    STRING: 10090.ENSMUSP00000064241

    UniGene: Mm.1738