Mouse Collagen alpha-1(XVIII) chain (COL18A1/ES) ELISA kit

Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.; May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling.; Potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. Inhibits VEGFA isoform VEGF165-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5. May negatively regulate the activity of homotrimeric non-collagenous domain 1.

1. This study examined the staining levels of proteasomal and autophagy markers in the RPE of different ages of the Col18a1 (-/-) mice. Eyes from 3, 6-7, 10-13 and 18 months old mice were enucleated and embedded in paraffin according to the routine protocol. PMID: 27125427
2. Kidney fibrosis in aging may represent a natural outcome of upregulated endostatin (EST) and transglutaminase 2 (TG2), but more likely it appears to be a result of cumulative stresses occurring on the background of synergistically acting geronic (aging) proteins, EST and TG2. PMID: 27165830
3. Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining PMID: 25024173
4. There are correlations between the elevation of endostatin levels and parallel microvascular rarefaction and induction of renal fibrosis in aging mice. PMID: 24727495
5. An excess of the collagen XVIII Tsp-1 domain is deleterious in the eye, possibly by impairing certain functions of the full-length molecule. PMID: 24135756
6. The results of the present study indicate endostatin promotes soft callus formation but inhibits callus remodeling during fracture healing most probably by an inhibition of angiogenesis. PMID: 23720153
7. Type XVIII collagen is an important functional component of the liver matrix microenvironment and is crucial for hepatocyte survival during injury and stress. PMID: 23580202
8. Data indicate that delivery by attenuated Salmonella of the combination therapeutic plasmid simultaneously knocked down the expression of Stat3 and resulted in over-expression of Endostatin, which synergistically inhibited prostate cancer growth. PMID: 23463096
9. Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition PMID: 22733742
10. Women with early-onset, but not late-onset preeclampsia have higher levels of endostatin than healthy pregnant women in corresponding lengths of gestation. PMID: 19564642
11. Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane PMID: 21193414
12. Data show that Col18-deficiency causes hypertriglyceridemia in mice. PMID: 21085708
13. In vivo, Collagen XVIII/endostatin does not play an indispensable role in skeletal development PMID: 19763371
14. the local synthesis of a 28-kDa ES-related fragment following acute kidney injury and suggest its role in endothelium survival PMID: 20110665
15. Lack of collagen XVIII/endostatin results in eye abnormalities. PMID: 11927538
16. Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis PMID: 11991745
17. Endostatin expression effectively inhibits mammary neoplasms growth in nude mice PMID: 12673115
18. Col18a1 knockout mice have iris and ciliary body defects. PMID: 14525950
19. Col18a1 is essential for vision and retinal pigment epithelial function. PMID: 14685281
20. there is a putative integrin-binding sequence with anti-migratory activity within endostatin PMID: 14973128
21. Collagen XVIII and enamelysin were co-localized in the developing enamel matrix and stratum intermedium and in the enamel-like tumor matrix of odontogenic tumors. PMID: 15296943
22. Studies in knockout mice identify a previously unrecognized function for collagen XVIII in vascular permeability. Loss of collagen XVIII enhances angiogenesis & vascular permeability in atherosclerosis by distinct gene-dose-dependent mechanisms. PMID: 15313955
23. collagen XVIII's C-terminal endostatin domain harbors a prominent tissue-binding site, which can bind in the absence of heparan sulfates in situ PMID: 15614762
24. In knockout mice, a widening of the epidermal basement membrane (BM) zone of the skin was observed in electron microscopy. PMID: 15632014
25. angiostatic function is heparan sulfate-dependent, and in situ-binding of endostatin to endothelial cells is increased by heparan sulfates PMID: 15694132
26. The p.D104N allele was found in trans with a pathogenic frameshift mutation in a healthy carrier of Knobloch syndrome, showing it is not very harmful. It may be a modifier or at-risk allele. PMID: 15714516
27. Collagen XVIII is localized in various basement membranes and is highly expressed throughout the connective tissue core of the endocardial cushions and embryonic atrioventricular valve leaflets; it may have a role in cardiac valve morphogenesis. PMID: 16170784
28. Exposure to hypoxia resulted in organ-specific, long-term increase of 24 & 26 kDa endostatin fragments in mouse aorta & lung. PMID: 16465514
29. Proteolytic matrix fragment endostatin(ES) is prominent vasorelaxing agent. Because ES is constantly released into the blood, it is novel regulator of blood pressure and represents an interesting pharmacological target. PMID: 16574906
30. Data show that upon experimental and human renal ischemia/reperfusion, microvascular basement membrane (BM) heparan sulfate proteoglycans (collagen 18alpha1, agrin and perlecan) are modified to bind L-selectin and monocyte chemoattractant protein-1. PMID: 17525255
31. following resection of cirrhotic liver, regeneration capacity is depressed and high endostatin levels are independent of hepatic regeneration PMID: 17574579
32. Results show that endogenous endostatin and its related peptides are widely distributed in all in vivo tumor types tested, but not in most of the cultured tumor cell lines. PMID: 17727259
33. Local synthesis of a 30 kDa endostatin-related fragment following acute renal failure. Role in the modulation of renal capillary density. PMID: 17803469
34. Endostatin binding to ovarian cancer cells inhibits peritoneal attachment and dissemination PMID: 18006826
35. D104N polymorphism of the COL18A gene may be an important inherited determinant of the LC susceptibility. PMID: 18054814
36. Inhibition of tumor angiogenesis by endostatin at an early stage in skin tumor development and an inhibition of lymph node metastasis. PMID: 18089781
37. study shows that a lack of collagen XVIII accelerates wound vascularisation and the rate of cutaneous wound healing whereas an excess of endostatin leads to delayed wound healing PMID: 18455382
38. These data indicate that collagen XVIII may play an important role in corneal reinnervation after wounding. PMID: 18840438
39. Report effects of endostatin production on oncogenicity and metastatic activity of HPV16-transformed mouse cells: role of interleukin 1alpha. PMID: 19513570

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Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, extracellular matrix, basement membrane.; [Non-collagenous domain 1]: Secreted, extracellular space, extracellular matrix, basement membrane. Secreted.; [Endostatin]: Secreted. Secreted, extracellular space, extracellular matrix, basement membrane.

Multiplexin collagen family

Expressed in liver, kidney, lung, skeletal muscle and testis.

KEGG: mmu:12822

STRING: 10090.ENSMUSP00000101049

UniGene: Mm.4352