Mouse Complement 5,C5 ELISA Kit

Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.; Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

1. In mice that lost the ability to express complement C5, there was a lower frequency of metastasis, and males no longer had a higher frequency of metastasis than females. PMID: 27105526
2. C5 contributes effectively to liver steatosis and inflammation in non-alcoholic fatty liver disease pathogenesis PMID: 27477770
3. C5a in vitro caused activation (phosphorylation) of MAPKs and Akt in cardiomyocytes, which required availability of both C5a receptors. These data suggest that polymicrobial sepsis causes cardiac dysfunction that appears to be linked to activation of MAPKs and Akt in heart. PMID: 28572445
4. data suggest a novel role for the anaphylatoxin C5a as a master switch of the delicate pHi balance in neutrophils resulting in profound inflammatory and metabolic changes that contribute to hyperlactatemia during sepsis. PMID: 28490576
5. n the complex but clinically relevant DH model the local and systemic inflammatory immune response features both, C5-dependent and C5-independent characteristics. Activation of caspase-3 in lung tissue after DH was C5-dependent whereas local inflammation in lung tissue was C5-independent. PMID: 27437704
6. We induced anti-myeloperoxidase vasculitis in bone marrow chimaeric mice and found that circulating and not bone marrow-derived C5 was required for disease PMID: 27235854
7. Choroidal neovascularization lesions trigger a systemic immune response, augmenting local ocular inflammation via the infiltration of IL-17-producing gamma-delta T-cells, which are presumably recruited to the eye in a C5a-dependent manner. PMID: 27029558
8. Carboxypeptidase B2 deficiency reveals that complement C5a exacerbates infection in a murine polymicrobial sepsis model. PMID: 25851247
9. In mice, loss of C5 or injection of a C5a-receptor antagonist significantly reduced the level of fibrosis of chronic pancreatitis. PMID: 26001927
10. C5a signaling increases the expression of the chemokine monocyte chemoattractant protein-1 in hepatic metastases of colon cancer PMID: 25739439
11. C5a produced during lung injury binds to C5aR in alveolar macrophages, initiates downstream signaling that promotes autophagy. PMID: 25032853
12. Loss of C5a is associated with atherosclerotic plaques. PMID: 25124749
13. Protein kinase C-delta mediates sepsis-induced activation of complement 5a and urokinase-type plasminogen activator signaling in macrophages PMID: 24682410
14. Activation of the complement cascade (ComC) and cleavage of C5 by C5 convertase are enabling events in the release of C5a that plays a crucial role in the egress of hematopoietic stem cells from bone marrow. PMID: 24667943
15. Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury. PMID: 25172497
16. The C5(-/-) mice displayed significantly reduced lumenal inflammatory infiltration and cytokine production in oviduct tissue, suggesting that C5 may contribute to chlamydial induction of hydrosalpinx by enhancing inflammatory responses. PMID: 24842924
17. Complement component C5a contributes to fetal cortical brain injury in a mouse model of preterm birth. PMID: 24184716
18. C5 plays an important role in glaucoma, with its deficiency lessening disease severity. PMID: 23806181
19. C5a regulates IL-12(+)dendritic cell migration to induce pathogenic Th1 and Th17 cells in sepsis. PMID: 23936099
20. lipocalin OmCI ameliorates murine immune complex-induced acute lung injury in a process involving inhibition of LTB4 and C5 PMID: 23625922
21. component 5a has a role in vascular integrity and airway remodeling PMID: 23530212
22. C5a generating enzyme included in cowshed dust extract (CDE) might account for some of the allergy protective effects of CDE by generation of C5a in murine lungs. PMID: 23093649
23. unilateral uterine ischemia/reperfusion results in bilateral fetal loss and fetal growth restriction, mediated by a systemic mechanism. In the current model, this pathological process is completely dependent on intact complement component 5. PMID: 22688254
24. The presence of C5a in tumor-bearing mice renders naive innate leukocytes more cytotoxic to tumor cells, and indicates C5a has activating potential of naive neutrophils and/or natural killer (NK) cells for superior effector function. PMID: 22914051
25. C5a robustly suppresses IL-27(p28) gene expression and release in peritoneal macrophages. PMID: 22491257
26. These results strongly suggest that the complement component 5 (C5) plays a critical role in early protective inflammatory response to infection with Taenia crassiceps. PMID: 22206032
27. C5 deficiency leads to attenuated inflammation and normalized MMP-9 activity concomitantly with a significant reduction of fibrosis. PMID: 22277671
28. IL-17F was produced in peritoneal macrophages after TLR4 activation, peaking after 12 h. This effect was completely dependent on the presence of MyD88. The copresence of the complement activation product C5a amplified IL-17F production. PMID: 21859896
29. Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent. PMID: 22199395
30. P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent. PMID: 22057273
31. Data demonstrate that high locally generated C5a levels are present in wounds for at least 72 hours after incision. PMID: 21736743
32. Dysregulation of complement C5 in synovial joints has a key role in the pathogenesis of osteoarthritis. PMID: 22057346
33. C5a alters blood-brain barrier integrity by signaling through CD88 and thereby disturbs the brain microenvironment. PMID: 21929539
34. Our results identify C5aR activation as a novel pathway driving detrimental effects of NKT and NK cells during early experimental sepsis. PMID: 22058413
35. Complement component 5 contributes to poor disease outcome in a pneumococcal meningitis model. PMID: 21926466
36. Complement C5b-9 induce a JNK/Bid-dependent and JNK-independent necrotic cell death. PMID: 19864026
37. The development of atypical hemolytic uremic syndrome depends on complement C5. PMID: 21148255
38. Antibody-mediated blockade of C5, treatment with C5a Receptor antagonist, or C5a Receptor deficiency in mice resulted in enhanced pathological retina angiogenesis. PMID: 20625009
39. these data provide compelling evidence for a protective role of C5a during bloodstream infection by Staphylococcus aureus. PMID: 20375626
40. The data suggest that complement activation by exogenous or endogenous stimulation can initiate Th17 cell differentiation and expansion in certain autoimmune diseases and presumably in microbial infections. PMID: 20457757
41. C5a participates in the regulation of IL-17 secretion by gammadelta T cells following sepsis after cecal ligation and puncture. C5a acted on DC, which subsequently induced T cells to secrete IL-17. PMID: 20140904
42. Complement Ca activates expression of the mRNA encoding cyclooxygenase 2 but not cyclooxygenase 1 in the hypothalamus. PMID: 19800413
43. function in regulating the inhibitory/activating FcgammaRII/III receptor pair to connect complement and FcgammaR effector pathways in immune inflammation PMID: 12488432
44. C5 may be required for the limitation of inflammatory response within the central nervous system. PMID: 15033785
45. Complement C5 may be required in experimental autoimmune encephalomyelitis for clearance of apoptotic inflammatory cells and protection of oligodendrocytes from Fas-dependent apoptosis, possibly through activation of the terminal C5b-9 complex. PMID: 15100315
46. causative role of C5 deficiency in the dysregulated cytokine response to Candida albicans PMID: 15385488
47. genome scan provides additional evidence confirming the role of C5 as a probable candidate gene for collagen-induced arthritis 2 and collagen-induced arthritis 4 loci PMID: 15529344
48. C5 has a causal role in fibrogenesis across species PMID: 15995705
49. plays a significant role in mediation of chemotactic and activation events during mycobacterial infection PMID: 16101818
50. data suggest that, in the genetic absence of C3, thrombin substitutes for the C3-dependent C5 convertase to produce C5a; this linkage between the complement and coagulation pathways may represent a new pathway of complement activation PMID: 16715088

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Secreted.

KEGG: mmu:15139

STRING: 10090.ENSMUSP00000028233

UniGene: Mm.2168