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  4. Mouse Complement C1q tumor necrosis factor-related protein 3(C1QTNF3) ELISA kit

Mouse Complement C1q tumor necrosis factor-related protein 3(C1QTNF3) ELISA kit

  • 中文名称：
    小鼠补体C1q肿瘤坏死因子相关蛋白3(C1QTNF3)酶联免疫试剂盒
  • 货号：
    CSB-EL003648MO
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Mouse C1QTNF3 ELISA Kit was designed for the quantitative measurement of Mouse C1QTNF3 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 3.12 ng/mL-200 ng/mL and the sensitivity is 0.78 ng/mL.

  • 别名：
    C1qtnf3 ELISA Kit; Cors26 ELISA Kit; Ctrp3 ELISA Kit; Complement C1q tumor necrosis factor-related protein 3 ELISA Kit; Collagenous repeat-containing sequence 26 kDa protein ELISA Kit; CORS26 ELISA Kit; Secretory protein CORS26 ELISA Kit
  • 缩写：
    C1QTNF3
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    3.12 ng/mL-200 ng/mL
  • 灵敏度：
    0.78 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Others
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse C1QTNF3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 92
    Range % 87-96
    1:2 Average % 101
    Range % 97-106
    1:4 Average % 93
    Range % 86-97
    1:8 Average % 91
    Range % 87-95
  • 回收率：
    The recovery of mouse C1QTNF3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 96 92-101
    EDTA plasma (n=4) 98 94-102
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    200 2.123 2.268 2.196 2.045
    100 1.478 1.548 1.513 1.362
    50 0.941 0.958 0.950 0.799
    25 0.586 0.597 0.592 0.441
    12.5 0.412 0.403 0.408 0.257
    6.25 0.302 0.309 0.306 0.155
    3.12 0.218 0.224 0.221 0.070
    0 0.150 0.151 0.151 　
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 基因功能参考文献：
    1. Low C1QTNF3 expression is associated with polycystic ovarian syndrome. PMID: 29438034
    2. Although it is dispensable for physiological control of energy balance, CTRP3 plays a previously unsuspected role in modulating liver size and circulating cytokine levels in response to obesity. PMID: 26670485
    3. CTRP3 was expressed in developing skeletal muscle tissues, and the expression level of CTRP3 was increased during myogenic differentiation of C2C12 cells. PMID: 26272338
    4. Our study suggests that CTRP3 prevents osteoclast differentiation PMID: 26103094
    5. Data suggest that CTRP3 up-regulates expression and secretion of adipokines (adiponectin, leptin, visfatin, and apelin) in adipocytes; these responses to CTRP3 are down-regulated by insulin resistance or inhibition of AMPK signaling pathway. PMID: 25168658
    6. present study shows the proof of principle that the novel adipokine CTRP-3 is a potent inhibitor of LPS-induced systemic inflammation and LPS-induced signaling in adipose tissue in vivo PMID: 24996172
    7. CTRP3 promotes vascular calcification by enhancing phosphate-induced osteogenic transition of VSMC through reactive oxygen species-extracellular signal-regulated kinase 1/2-Runx2 pathway. PMID: 24578384
    8. These observations indicate that CTRP3 plays an important role in the development of autoimmune arthritis, suggesting CTRP3 as a possible medicine to treat rheumatoid arthritis. PMID: 24269820
    9. results establish a novel role for C1q tumor necrosis factor-related protein 3 (CTRP3) in regulating hepatic lipid metabolism and highlight its protective function and therapeutic potential in attenuating hepatic steatosis PMID: 23744740
    10. c-Jun is a cis-acting element for CTRP3 regulation in chondrogenic cells. PMID: 22644487
    11. CTRP3 is a novel antiapoptotic, proangiogenic, and cardioprotective adipokine, the expression of which is significantly inhibited after myocardial infarction. PMID: 22653084
    12. This study provides the first functional evidence linking CTRP3 to hepatic glucose metabolism and establishes CTRP3 as a novel adipokine. PMID: 20952387
    13. Exogenous CTRP3/cartducin promoted the proliferation of p53LMAC01 cells in a dose-dependent manner via ERK1/2 (extracellular signal-regulated kinase 1/2)- and MAPK (p38 mitogen-activated protein kinase)-signalling pathways PMID: 19947921
    14. Genomic organization, chromosomal localization and adipocytic expression of the murine gene for CORS-26 PMID: 12850274
    15. the murine CORS-26 promoter is transcriptionally regulated by specificity protein-1, PPARgamma, and pituitary protein transcription factor-1 PMID: 15157741
    16. Cartducin is a novel growth factor and plays important roles in regulating both chondrogenesis and cartilage development by its direct stimulatory action on the proliferation of chondrogenic precursors and chondrocytes. PMID: 16155912
    17. CORS-26 up-regulates adipokine secretion and might be involved in metabolic and immunologic pathways. PMID: 17299102
    18. Elevated expression of CTRP3/cartducin contributes to promotion of osteosarcoma cell proliferation PMID: 19424626

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：