Mouse Leptin receptor,LR/Ob-R ELISA KIT

Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity. Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production.; May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3.; Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis.

1. Knockin of Lepr in beta cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia. PMID: 28580288
2. Abnormal sex hormone levels of Y123F mice were due to not only decreased gonadotropin levels in the central nervous system, but also ovarian hormone synthase abnormalities in the peripheral gonads. PMID: 29728128
3. Expression of IGF-1 and LEPR indicates a relevant role in androgenic features reversion present in PCOS, hormonal equilibrium, body weight regulation, and glucose metabolism, therefore, under phenotype obesity and infertility regulation in this model. PMID: 29430464
4. The leptin-receptor mice is not a proper model for secondary osteoporosis associated with type 2 diabetes mellitus. PMID: 27283954
5. Data show that leptin receptor deficient (LeprNULL) mice exhibited increased body weight and food intake. PMID: 28938472
6. This study reports about bone quality and bone turnover mechanisms in leptin receptor-deficient animals. PMID: 26990203
7. Neurotensin-leptin receptor neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors. PMID: 28323938
8. Identify Lepr(+) stromal lineage cells as the origin of myofibroblasts in primary myelofibrosis and suggest that targeting PDGFRA signalling could be an effective way to treat bone marrow fibrosis. PMID: 28481328
9. Leptin expression is regulated by DNA methylation in adipocytes. PMID: 27494408
10. Attenuated leptin-receptor (LEPR) expression is essential for the development and maintenance of acute lymphoblastic leukemia (ALL), and that fasting inhibits ALL development by upregulation of LEPR and its downstream signaling through the protein PR/SET domain 1 (PRDM1). PMID: 27941793
11. LepRb preoptic area neurons are stimulatory glutamatergic neurons, contrary to prevalent models PMID: 27147656
12. Leptin receptors on agouti-related peptide neurons modulate the onset of puberty and adult fertility. PMID: 28275162
13. Leptin/LepR signaling regulates adipogenesis and osteogenesis by mesenchymal stromal cells in the bone marrow in response to diet and adiposity. PMID: 27053299
14. These data show that leptin directly impairs vascular relaxation via a vascular skeletal muscle-LepR-mediated mechanism, suggesting a potential pathogenic role for leptin to increase cardiovascular risk during obesity. PMID: 26936780
15. These mice showed an increase in FSH levels, but they remained in a prepubertal state. Together with previous findings, our data indicate that leptin-selective action in gonadotropes serves a role in adult reproductive physiology but is not sufficient to allow pubertal maturation in mice. PMID: 27101301
16. we report that estradiol has minimal direct actions on LepRb cells in the mediodasal hypothalamus and that its anorexigenic effects can occur entirely independently of LepRb-STAT3 signaling in female mice. PMID: 26937712
17. leptin/ObRb-mediated signals were enhanced in hypothalamus of GD3S KO mice due to increased a-series gangliosides, leading to the apparently similar features of energy expenditure between the KO and wild type mice PMID: 27644882
18. Data suggest that hypothalamic leptin/leptin receptor signaling plays a critical role in neurodevelopment, sympathetic activation, and prevention/development of hypertension. [REVIEW] PMID: 27613336
19. HFD-induced lipotoxicity and deregulated organelle biosynthesis confer cancer stem cell-like properties to the gastric mucosa via signaling pathway mediated by the leptin receptor, leptin, PI3K and beta-catenin PMID: 27693038
20. Leptin receptor expressing neurons express phosphodiesterase-3B (PDE3B) and leptin induces STAT3 activation in PDE3B neurons in the mouse hypothalamus. PMID: 26297880
21. JAK-STAT and hormone biosynthesis pathways were involved in the follicular development and ovulation disorders caused by LepR deficiency in ovaries PMID: 26529315
22. Diet- and Genetically-Induced Obesity Differentially Affect the Fecal Microbiome and Metabolome in Apc1638N Mice PMID: 26284788
23. Global loss of the leptin receptor results in reduced viral clearance and worse outcomes following influenza A infection. PMID: 25232724
24. Human and murine pancreatic cancer cell lines were found to express the short as well as the long form of the leptin receptor and functionally responded to leptin induced activation through an increased phosphorylation of AKT473. PMID: 25919692
25. vital role in the optimization of somatotrope lipolytic function, especially in the young male PMID: 26168341
26. absence of leptin receptor on thymic epithelial cells or T cells does not lead to the loss of thymic function, demonstrating the thymoprotective effect of leptin is mediated by obesity suppression rather than signalling to the thymus. PMID: 26059465
27. High LEPR expression is associated with onset of obesity. PMID: 24928195
28. The newly recognized effect of the leptin receptor Q223R mutation on diminished neutrophil chemotaxis and the impact of this mutation on multiple infectious diseases suggest a broader impact of this mutation on susceptibility to disease. PMID: 25516614
29. LepR(+) cells are the major source of bone and adipocytes in adult bone marrow PMID: 24953181
30. Leptin knockouts are hyperphagic and obese, whereas insulin receptor knockouts are similar to controls but double knockouts exhibit higher body weight and adiposity solely due to reduced energy expenditure. PMID: 25125486
31. This study investigated the importance of fetal genotype (db/+) relative to abnormal maternal metabolism for placental function and therefore fetal growth and offspring health. PMID: 25353183
32. Leptin receptor deficiency or antagonism profoundly affects metabolism, with little concomitant effects on immune functions. PMID: 25098352
33. Results suggest that endospanin 1 (also named OB-RGRP) is implicated in obesity development and/or the installation of leptin resistance. PMID: 24784449
34. Hypoglycemia activates neurons of the parabrachial nucleus that express leptin receptors. PMID: 25383904
35. A markedly elevated leptin production from inflamed visceral fat could deteriorate beta-cell function via leptin receptor-mediated oxidative stress and cyclooxygenase-2 activation in the development of obesity PMID: 25123537
36. leptin binding to the Q223R leptin receptor PMID: 24743494
37. Collectively, these studies highlight the importance of LEP/LEPR to gonadotropes with GnRH-binding sites and activin as potential targets. LEP/LEPR may modulate population growth, adjusting the number of offspring to the availability of food supplies. PMID: 25057790
38. Obese diabetic mice lacking leptin receptor (db/db) are deficient in postnatal regenerative osteogenesis. PMID: 24343796
39. Expression of Lepr in the liver, but not in the hypothalamus, was up-regulated in Helz2 knockout mice. PMID: 25004093
40. LEPR223Arg allele (rs1137101) was associated with higher daily energy intake at 4 years of age. PMID: 24343628
41. STAT3 is one of the important molecules downstream of LEPR, and LEPR/STAT3 signaling controls tumor cell proliferation. PMID: 24958593
42. Arcuate nucleus neurons express a functional leptin receptor throughout early postnatal development. PMID: 25057200
43. Lepr(db/db) mice fed a diet high in unsaturated fat develop weight gain and NASH through adiponectin depletion, which is associated with adipose tissue inflammation and hepatic mitochondrial dysfunction. PMID: 24464605
44. results demonstrate that leptin receptor is dramatically induced in the granulosa cells of ovulating follicles and this induction of Lepr expression requires the transcription factor CCAAT/enhancer-binding protein beta PMID: 24256641
45. The worsening of experimental autoimmune encephalomyelitis in the astrocyte specific leptin receptor knockout mouse suggests that astrocytic leptin signaling helps to clear infiltrating leukocytes and reduce autoimmune destruction of the CNS. PMID: 23916894
46. Loss of leptin receptor signaling in close to one-half of alpha-cells does not alter glucose metabolism in vivo, nor is it sufficient to prevent the therapeutic action of leptin in type 1 diabetes. PMID: 24473435
47. leptin can act directly on its receptors in peripheral tissues to regulate cell proliferation and differentiation PMID: 23967295
48. SOCS3-deficient epithelial cells in the stomach induce activation of leptin receptor signaling via STAT3 and initiates hyperproliferation, mimics intestinal metaplasia and eventually promotes adenocarcinoma formation. PMID: 23178499
49. Agrp(-/-) Lepr(db/db) females are fertile and sustain adequate nutrition of pups with lactation to weaning age. PMID: 24169048
50. 40% of Lepr-deficient (C57BL/KsJ-db/db) mice developed liver tumors after administration of thioacetamide compared with none of the control mice. PMID: 24055508

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Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane.; [Isoform E]: Secreted.

Type I cytokine receptor family, Type 2 subfamily

Isoform A: highest level of expression in lung and kidney, also present in heart, brain, spleen, liver, muscle, choroid plexus and hypothalamus. Isoform B: highest levels of expression in hypothalamus and lower levels in brain, testes and adipose tissue.

KEGG: mmu:16847

STRING: 10090.ENSMUSP00000037385

UniGene: Mm.259282