Mouse Reelin(RELN) ELISA kit

Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.

1. Dextran sulphate sodium (DSS)-colitis activates reelin production. DSS-colitis decreases the methylation of the reelin promoter region. PMID: 27915032
2. results highlight a role for reelin in maintaining intestinal epithelial cell homeostasis and providing resistance against colon pathology. PMID: 28572005
3. we determined that Reelin protein and mRNA levels increased in CJD human samples and in mouse models of human prion disease in contrast to murine models of prion infection. However, changes in Reelin expression appeared only at late terminal stages of the disease, which prevent their use as an efficient diagnostic biomarker. PMID: 27726110
4. These results indicate that Reelin is an important regulator of GPIb-mediated platelet activation and may represent a new therapeutic target for the prevention and treatment of cardio- and cerebrovascular diseases PMID: 28943410
5. ITSN1 is a component of Reelin signaling that acts predominantly by facilitating the VLDLR-Dab1 axis to direct neuronal migration in the cortex and hippocampus and to augment synaptic plasticity. PMID: 28484035
6. These results suggest that CTR-dependent Reelin functions are required for some specific normal brain functions and that DeltaC-KI mice recapitulate some aspects of neuropsychiatric disorders, such as schizophrenia, bipolar disorder, and autism spectrum disorder. PMID: 27346785
7. Reelin directly promotes N-cadherin-dependent neuronal adhesion, causing neuronal aggregation. PMID: 28174271
8. The results of this study reveal that the Reelin/Dab1 pathway contributes to the fine tuning of the density of perisynaptic astroglial ensheathment of synapses established on newborn Granule Cells, with overactivation of the pathway resulting in reduced ensheathment and Reelin-downregulation leading to increased ensheathment. PMID: 27624722
9. Model selection was performed on different model structures and a comprehensive mechanistic model of the early Reelin signaling cascade is provided in this work PMID: 29049379
10. found that Reelin protein with intact C-terminal region binds preferentially toPurkinje cells PMID: 27586054
11. This study demonstrated that both the loss of reelin protein expression, caused by genetic mutation, and prenatal pesticide exposure can alter the shape and connectivity of neurons in several brain regions. PMID: 27364165
12. CHD7 is necessary for maintaining an open, accessible chromatin state at the Reln locus. Taken together, this study shows that Reln gene expression is regulated by chromatin remodeling, identifies CHD7 as a previously unrecognized upstream regulator of Reln, and provides direct in vivo evidence that a mammalian CHD protein can control brain development PMID: 28165338
13. ADAMTS-3 was identified as the protease that cleaves and inactivates Reelin in the cerebral cortex and hippocampus. ADAMTS-3 was expressed in the excitatory neurons of the embryonic and postnatal cerebral cortex and hippocampus. PMID: 28213441
14. RELN R2290C heterozygous neurospheres reveals up-regulation of Protein Disulfide Isomerase A1, best known as an endoplasmic reticulum-chaperone protein PMID: 28419454
15. A C-terminal region truncation of the reelin protein causes abnormal phenotypes in the cerebral cortex and hippocampus. PMID: 28123028
16. This study demonstrated that Reelin Maintain Postnatal CA1 Hippocampus Integrity in mice. PMID: 27307241
17. Sex-associated and brain region-specific differences in reelin expression appear long before Abeta-plaque formation in AbetaPP mutant Alzheimer disease model. PMID: 27866325
18. These findings suggest that circulating Reelin promotes atherosclerosis by increasing vascular inflammation, and that reducing or inhibiting circulating Reelin may present a novel approach for the prevention of cardiovascular disease. PMID: 26980442
19. A new transgenic mouse model demonstrates that Reelin is a molecule which is critical for proper cortical development. PMID: 26662625
20. androgenic hormones can influence cerebral reelin demethylation PMID: 26526966
21. data suggest Kdm5b negatively regulates neurogenesis and represses reelin in neural stem cells from the adult subventricular zone. PMID: 26739753
22. reelin and cofilin cooperate in controlling cytoskeletal dynamics during neuronal migration. PMID: 26893343
23. Results suggest that Reelin induces branching of the leading processes of migrating neurons and that of basal processes of radial glial cells when they arrive at the Reelin-containing marginal zone. PMID: 25246510
24. Results revealed that lack of functional reelin does not simply invert, but highly disorganize visual cortical layers, resulting in a massive intermingling of cells with different laminar fates. PMID: 25119525
25. Report demonstrated that the reelin subregion R5-6 consisting of 747 amino acids in the 5th and 6th repeats was sufficient for apoER2 and VLDLR binding, and inhibiting lipoprotein-induced cholesterol accumulation in macrophages. PMID: 26317415
26. Findings indicate the physiological importance of Reelin in protecting the brain against amyloid beta (Abeta)-induced synaptic dysfunction and memory impairment. PMID: 26152694
27. suggest that Reelin-dependent signaling mechanisms may be split into Src-AKT-dependent and Src-Go-dependent pathways PMID: 26441085
28. Results of this study point to the Reelin signaling pathway as a candidate target for the pharmacologic treatment of neuropsychiatric diseases. PMID: 25573715
29. Application of Reelin enhances long-term potentiation, increases dendritic spine density and improves associative and spatial learning and memory. PMID: 25864922
30. Reelin depletion and stress impaired spatial memory, whereas either one of those factors alone was not sufficient to elicit this effect. Findings extend understanding of the role of reelin-stress interactions in schizophrenia. PMID: 25845740
31. Study showed increased expression in striatum membranes and decreased expression in frontal cortex membranes for both DRD2 and Htr2a receptors from heterozygous Reelin mutant mice compared to wild-type PMID: 25637489
32. Data suggest a role for Reelin in controling stem cell quiescence or, alternatively, in the proper organization of the stem cell niche during development. PMID: 25760459
33. The striatum and not the midbrain is the primary source of Reelin for midbrain neurons. PMID: 25418135
34. this study links Reelin-dependent dendritogenesis with migration arrest and cortical lamination. PMID: 26224852
35. This study demonstrated that a novel and detailed view of cytoarchitectural defects in the periarchicortex and Inversion of layer-specific cadherin expression of the reeler mouse. PMID: 24591110
36. Reelin plays a selective role in coagulation activation, leading to thrombin generation and formation of a normal fibrin clot PMID: 25255925
37. The Reelin C-terminal region is required for the development and maintenace of postnatal cerebral cortex. PMID: 25788693
38. Reelin expression is inhibited in post-stroke brain by increases in miR-200c. PMID: 25604249
39. When pregnant mice are exposed to EMF, reelin expression increases in the EMF-treated fetal cerebral cortex extracts as compared to controls and SHAM group. PMID: 24584565
40. The results suggest that reelin promotes microtubule assembly, at least in part, by increasing microtubule plus end dynamics. PMID: 22990595
41. Study finds that the extracellular matrix protein Reelin, acting through its downstream Dab1 and Src family tyrosine kinase signaling cascade, provides a non-cell-autonomous factor that specifies the identity of the distal dendritic compartment in both CA1 and L5 pyramidal neurons. PMID: 25201528
42. This study show that reelin is essential for structural, functional and behavioral development of juvenile prefrontal circuits and that this developmental period provides a critical window for therapeutic rehabilitation with GluN2B-NMDAR antagonists. PMID: 23752244
43. It findings link reelin with Dab1 and suggest that Dab1 functions downstream of reelin action on the homeostasis of the crypt-villus unit. PMID: 24313315
44. the full-length Reelin moiety, but not the central fragment, is capable of activating Erk1/2 signaling, leading to increased p90RSK phosphorylation and the induction of immediate-early gene expression PMID: 24876378
45. Suggest role for reelin/DAB-1 signaling promoting chondrogenic differentiation of digit mesodermal progenitors in embryonic limbs. PMID: 24519818
46. Data indicate that that N-t cleavage of Reelin is required for halting the signaling machinery in the extracellular space as well as within endosomes of target neurons. PMID: 24644294
47. Tangentially migrating dopaminergic neurons express the components of the reelin signaling pathway, whereas dopaminergic neurons in their initial, radial migration phase express CXCR4, the receptor for CXCL12. PMID: 24449842
48. In reeler mice, despite the severe morphological phenotype, the maturation and differentiation of radial glial cells are not affected during dentate gyrus development. PMID: 23828756
49. Reelin activates canonical survival pathways in the limb mesoderm involving protein kinase B and focal adhesion kinase. PMID: 24030152
50. distribution of the cell-specific markers, calretinin and calbindin, in reelin-immunoreactive cells during postnatal rat and mouse neocortical development PMID: 24134921

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Defects in Reln are the cause of the autosomal recessive reeler (rl) phenotype which is characterized by impaired motor coordination, tremors and ataxia. Neurons in affected mice fail to reach their correct locations in the developing brain, disrupting the organization of the cerebellar and cerebral cortices and other laminated regions.

Secreted, extracellular space, extracellular matrix.

Reelin family

The major isoform 1 is neuron-specific. It is abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellu

KEGG: mmu:19699

STRING: 10090.ENSMUSP00000124052

UniGene: Mm.425236