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  4. Mouse Secreted frizzled-related protein 3(FRZB) ELISA kit

Mouse Secreted frizzled-related protein 3(FRZB) ELISA kit

  • 中文名称：
    小鼠分泌卷曲相关蛋白3(FRZB)酶联免疫试剂盒
  • 货号：
    CSB-EL009008MO
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 别名：
    Frzb ELISA Kit; Fiz ELISA Kit; Fre ELISA Kit; Frzb1 ELISA Kit; Sfrp3 ELISA Kit; Secreted frizzled-related protein 3 ELISA Kit; sFRP-3 ELISA Kit; Frezzled ELISA Kit; Fritz ELISA Kit; Frizzled-related protein 1 ELISA Kit; FrzB-1 ELISA Kit
  • 缩写：
    FRZB
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 检测范围：
    Request Information
  • 灵敏度：
    Request Information
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Signal Transduction
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
  • 基因功能参考文献：
    1. particle-induced inhibition on cell proliferation, differentiation and FRZB expression were all reversed by miR-130b silence PMID: 28382864
    2. Stable overexpression of Frzb in MC3T3-E1 cells increased calcium deposition and osteoblast markers compared with control. Western blot analysis showed that the increased osteogenesis was associated with reduced canonical, but increased non-canonical Wnt signaling. PMID: 26927515
    3. an inverse septal-to-temporal increase in the expression of sfrp3 that emerges during postnatal development, is reported. PMID: 26337530
    4. The spatiotemporally dynamic expression ofsFRP3 strongly suggests that sFRP3 has potential functions in the sensory neuron genesis and sensory circuitry formation. PMID: 23827310
    5. Our results suggest that FrzB may have a protective role on cartilage degradation and matrix metalloproteinase induction in mouse chondrocytes PMID: 24984954
    6. left ventricles from post-MI mice showed an increased sFRP3 mRNA level, particularly in cardiac fibroblasts, and (iv) mechanical stretch enhanced sFRP3 expression and release in myocardial fibroblasts PMID: 24330105
    7. Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in mice. PMID: 23207650
    8. Study identifies sFRP3 as an inhibitory niche factor from local mature dentate granule neurons that regulates multiple phases of adult hippocampal neurogenesis. PMID: 23395446
    9. Data indicate an important role for frizzled-related protein (Frzb) in joint homeostasis and highlight the complex biology of WNT signaling in the joint. PMID: 22264237
    10. Secreted Frizzled-related proteins (sFrps) are expressed in the postnatal cerebral cortex in regional and lamina patterns in the major subdivisions of the cerebral cortex: the olfactory bulb, the hippocampal formation, and the neocortex. PMID: 15116386
    11. sFRP3 may stimulate differentiation through a beta-catenin-independent pathway in addition to its previously known function as a decoy receptor for Wnt's PMID: 15312239
    12. Loss of Frzb may contribute to cartilage damage by increasing the expression and activity of MMPs, in a WNT-dependent and WNT-independent manner. This may contribute to the development of osteoarthritis. PMID: 18050203
    13. Our findings support Wnt5a and sfrp3 as regulators of otic capsule formation in the developing mouse inner ear. PMID: 18991062

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Secreted frizzled-related protein (sFRP) family
  • 组织特异性：
    Expressed in kidney, brain, testis. Weak expression in spleen and heart.
  • 数据库链接：