Mouse Slit2 ELISA Kit

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development, may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system, appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.

1. High Slit-2 expression is associated with hepatic fibrosis. PMID: 29660433
2. Both ISL1-LHX3 and ISL1-LHX4 bound to the Slit2 enhancer. PMID: 27819291
3. Study provides evidence that Slit2 is a novel quantitative trait gene and a positive regulator of the number and function of murine hematopoietic stem cells. PMID: 27503415
4. Transgenic over-expression of slit2 enhances disruption of blood-brain barrier and increases cell death after traumatic brain injury in mice. This suggest that over expression of slit2 plays a detrimental role in the pathophysiology of mild TBI. PMID: 27521753
5. Slit2 induces a robust activation of PKA signaling, which is required for its prothermogenic activity. PMID: 26876562
6. Robo1-Slit2 interaction required for pathfinding mechanism essential to establish the functionally important habenulo-interpeduncular connection. PMID: 25366972
7. overexpression promoted vascular remodeling by increasing the diameter of the maternal blood sinusoids and fetal capillaries PMID: 26282852
8. Together, these observations suggest that Slit2 serves as a factor utilized by muscle Ctnnb1 to direct presynaptic differentiation. PMID: 26159615
9. Slit2 acts as a repellant cue to mediate axon guidance in the formation of the anterior commissure. PMID: 25904499
10. Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/beta-catenin pathway. PMID: 25605242
11. the two genes neuropeptide Y (Npy) and Slit homolog 2 (Drosophila) (Slit2) gradually increase during aging, and upon suppression of these two genes PMID: 26047956
12. Cardiac defects in mutants for Robo or Slit range from membranous ventricular septum defects to bicuspid aortic valves. PMID: 25691540
13. Data shows that modulation of angiostatic factor Slit2 by EphA2 receptor regulates endothelial responses to VEGF-mediated angiogenesis and tumor neovascularization. PMID: 25504371
14. administration of Slit2 to atherosclerosis-prone LDL receptor-deficient mice inhibited monocyte recruitment to nascent atherosclerotic lesions. PMID: 26297762
15. Results provide novel evidence that low expression of SLIT2 correlates with poor prognosis and promotes metastasis in ESCC, which may be regulated by the Cdc42-mediated pathways. PMID: 25490006
16. Slit2 may promote angiogenesis by upregulating Robo1 and activating the VEGFR2-ERK1/2 pathway. PMID: 26244297
17. Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract PMID: 26026792
18. Slit2 signaling through Robo1 and Robo2 has a role in retinal neovascularization PMID: 25894826
19. Results suggest that Slit2 might be involved in skin tumorigenesis. PMID: 24840330
20. Slit production is required for beta-cell survival and optimal function via a mechanism involving endoplasmic reticulum Ca2+ homeostasis and actin remodeling. PMID: 24065825
21. Prostaglandin F2alpha upregulates Slit2 and Robo1 expression in mouse corpus luteum during luteolysis. PMID: 23814012
22. Slit/Robo signaling imposes a restriction force on spiral ganglia neurons to ensure their precise positioning for correct spiral ganglia-cochlear hair cells innervations. PMID: 23884932
23. This study demonistrated that Slit2 can act alone to control aspects of retinal axon routing across the ventral diencephalic midline. PMID: 23320558
24. Slit/Robo1 signaling is involved in regulating neural tube development by tightly coordinating cell proliferation and differentiation during neurulation. PMID: 23438940
25. This study report that central nervous system progenitors express Robo1 and Robo2, receptors for Slit proteins that regulate axon guidance, and that absence of these receptors or their ligands leads to loss of ventricular mitoses. PMID: 23083737
26. The cell motility modulator Slit2 is a potent inhibitor of platelet function. PMID: 22865890
27. Data show that the gooseberry/gooseberry-neuro (gsb/gsb-n) transcription factor genes act to specify MP3 cell fate. PMID: 22912413
28. The results of this study supported the idea that Slit2 promotes axon fasciculation via an autocrine and/or juxtaparacrine mechanism. PMID: 22306607
29. Over-expression of human Slit2 in transgenic mouse significantly increased brain vessel density and the permeability of brain vessels to large molecules. PMID: 21986575
30. the midline repellent Slit2 orients migration of corridor neurons and thereby switches thalamic axons from an external to a mammalian-specific internal path. PMID: 21435555
31. Cooperation between Slit2 and ephrin-A1 regulates a balance between the pro- and antiangiogenic functions of Slit2. PMID: 21135133
32. Slit2 expression (and that of Slit3) are linked to posttranscriptional regulation of Robo receptors during blood vessel development. PMID: 20947829
33. the newly identified Slit2 gradient at the bronchus-alveoli axis induces attractive PI3K signaling in eosinophils and repulsive srGAP1 signaling in neutrophils through differential srGAP1 expression during lung inflammation. PMID: 20944010
34. Activating with the soluble ligand Slit an endothelium-specific, Robo4-dependent signaling pathway that strengthens the vascular barrier, diminishing deleterious aspects of the host's response to the pathogen-induced cytokine storm. PMID: 20375003
35. N-Slit2 promoted neuronal survival and neurite extension in chick dorsal root and autonomic ganglia. Slit2 also promoted neuronal survival in mouse dorsal root ganglia. PMID: 12488830
36. Slit2 mRNA was intensely expressed in GFAP-positive astrocytes surrounding necrotic brain tissue, suggesting that slit2 might prevent regenerating axons from entering into the lesion. PMID: 12655597
37. The principle function of Slit2 at the cortical midline may be to channel the axons along the correct path and possibly repel them away from the midline. We find no evidence that Slit2 prevents axons from recrossing the midline in the brain. PMID: 12954881
38. Slit2 inhibits the migration of Langerhans cells out of the skin, suppressing the development of contact hypersensitivity responses after hapten sensitization. PMID: 14662852
39. Experiments with triple mutant mice demonstrate a key role for Slit2 signaling in vertebrate midline commissural axon guidance. PMID: 15091338
40. Mutants lacking SLIT2 develop supernumerary ureteric buds that remain inappropriately connected to the nephric duct; the SLIT2 signal is transduced in the nephrogenic mesenchyme. PMID: 15130495
41. Slit-2 and Robo-1 expression is present throughout mesenchyme at midgestation and is not detectable by newborn day 1 PMID: 15162513
42. SLIT2 acts in parallel with NTN1 to generate cell boundaries along ducts during bi-layered tube formation. PMID: 16439476
43. Slit2 helps prevent retinal ganglion cell axons from crossing the diencephalic/telencephalic boundary in the developing optic tract. PMID: 16828733
44. The role of Slit2-Robo signaling in gthe generation, migration and morphological differentiation of cortical interneurons is reported. PMID: 18054781
45. Slit2 plays a role in regulating in vitro osteoblast differentiation. PMID: 19033678
46. Slit2 inhibits tumor growth and metastasis of fibrosarcoma and squamous cell carcinoma and its effect on cell cycle and apoptosis signal pathways is an important mechanism for Slit2-mediated tumor suppression PMID: 19048120
47. These findings suggest that the combination of Netrin and Slit may be involved in proper axonal projection from the mammillary bodies and that their misexpression in the diencephalon may cause the misrouting of these axons in Pax6 mutant mice. PMID: 19115401
48. Slit2 potently inhibits chemotaxis but not random motion of circulating neutrophils PMID: 19759280
49. Slit2 mRNA level decreased during development of vascular decline in pulmonary fibrosis. PMID: 17496152

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Secreted.

Expressed in developing eye, in the optic stalk, and in the ventral diencephalon.

KEGG: mmu:20563

STRING: 10090.ENSMUSP00000127615

UniGene: Mm.289739