Mouse Somatostatin,SS ELISA Kit

Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin.; May enhance low-glucose-induced glucagon release by pancreatic alpha cells. This effect may be mediated by binding to GPR107 and PKA activation. May regulate cardiac contractile function. May compromise cardiomyocyte viability. In the central nervous system, may impair memory retention and may affect hippocampal excitability. May also have anxiolytic and anorexigenic effects. May play a role in arterial pressure regulation. May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH.

1. We show that removal of the paracrine influence of SST suppresses the ability of KATP channel blockers or KATP channel ablation to inhibit glucagon release PMID: 30115649
2. Synapses from somatostatin-expressing interneurons are regulated by NMDA receptors, signaling through R-type calcium channels. PMID: 29295931
3. The findings reveal a proaddiction adaptive response to chronic nicotine in which nitric oxide and SST are released by a specific CHRNA5-expressing neuronal population to provide retrograde inhibition of the habenula- interpeduncular nucleus circuit and thereby enhance the motivational properties of nicotine. PMID: 29158387
4. Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice. PMID: 27901064
5. HIV-1 Tat causes cognitive deficits and selective loss of parvalbumin, somatostatin, and neuronal nitric oxide synthase expressing hippocampal CA1 interneuron subpopulations. PMID: 27178324
6. Suppressing somatostatin (SOM) neurons enhanced the Excitation and Inhibition underlying size tuning, explaining SOM neurons' role in surround suppression. PMID: 28858618
7. dendrite-targeting somatostatin interneurons are critical for a visually induced, context-dependent gamma rhythm in visual cortex. PMID: 28481348
8. The results of this study provided the first in vivo evidence that SOM(+) neurons represent a Central Amygdala population that acquires learning-dependent sensory responsiveness during fear conditioning and furthermore reveal an important role of these neurons in gating passive versus active defensive behaviors. PMID: 27307236
9. preinspiratory Dbx1 neurons are rhythmogenic, inspiratory Dbx1+ and SST+ neurons primarily act to pattern respiratory motor output, and SST+-neuron-mediated pathways and postsynaptic inhibition modulate breathing pattern. I PMID: 27497222
10. Endogenous SST and CORT distinctly impact on DMBA-induced mammary gland tumorigenesis , in a manner that is strongly dependent on the metabolic/endocrine milieu (lean vs. obese status). PMID: 26956474
11. This study demonstrated that Hippocampal Somatostatin Interneurons Control the Size of Neuronal Memory Ensembles. PMID: 26875623
12. Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic alpha-cells. PMID: 26561648
13. Data indicate that somatostatin (SST)-secretion is regulated by incretin hormones, cholecystokinin, acetylcholine, vasoactive intestinal polypeptide, calcitonin gene-related polypeptide, oligopetides, and trace amines. PMID: 26241122
14. Data indicate all gastric mucosa receptors through which somatostatin (SST) secretion is regulated by hormones, neurotransmitters, neuropeptides and metabolites that act directly on the SST cells. PMID: 26181106
15. The data of this study suggested that (1) low SST has a causal role in mood-related phenotypes, (2) deregulated EIF2-mediated protein translation PMID: 25600109
16. The PTEN autism spectrum disorder alleles are hypomorphic in regulating cell size and the parvalbumin/somatostatin ratio in comparison to WT PTEN. PMID: 25937288
17. Nearly all parvalbumin interneurons express Lynx1 did not detect Lypd6 in this population. Conversely, in somatostatin interneurons Lypd6 was found in a subset localized to deep cortical layers but no somatostatin neurons show detectable levels of Lynx1. PMID: 25359633
18. The paracrine actions of Ucn3 activate a negative feedback loop that promotes somatostatin release to ensure the timely reduction of insulin secretion upon normalization of plasma glucose. PMID: 26076035
19. Levels of TGF-beta1, a factor implicated in tissue remodelling, together with SMAD phosphorylation through which TGF-beta mediates its effects, were increased in the somatostatin knockout pancreas. PMID: 25350519
20. SOM regulates both parasite burden and granulomatous inflammation perhaps through modulating granuloma production of IFN-gamma and IL-1b PMID: 25530957
21. The role of somatostatin in the expression of growth hormone in male and female mice is reported. PMID: 25551181
22. Somatostatin and insulin together are critical paaracrine mediators of glucose-inhibited glucagon secretion and function by lowering cAMP/PKA signaling with increasing glucose. PMID: 25406263
23. Somatostatin-containing interneurons are involved in learning-induced changes in the inhibitory cortical network. PMID: 24055404
24. Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome. PMID: 25024183
25. SST, in a circadian manner and putatively via its regulation of expression in the amygdala, modulates behavior responding to mildly aversive conditions in mice. PMID: 24376834
26. Somatostatin-positive interneuron populations are altered by thyroid hormone deficiency. PMID: 24333174
27. when activated by SST-14, SSTR2A internalizes and recycles via the Golgi, which requires ECE-1 degradation of SST-14 and receptor dissociation from beta-arrestins PMID: 23913690
28. Findings suggest that somatostatin and its receptors (SSTR2 and SSTR5) are important markers in the regulation and development of Sertoli cell. PMID: 23831358
29. The results further support a role for endogenous SST in regulating l-Arg-mediated insulin release. PMID: 23696563
30. SST-like immunoreactivity, while comparable in most regions of hypothalamus, diminished significantly in arcuate nucleus of ApoD(-/-) mice. PMID: 22581439
31. Expression of somatostatin mRNA was increased in the hypothalamus in anorectic mice fed a Val-deficient diet. PMID: 21293891
32. Nkx2.2-/-Arx- ghrelin+ cells also express the somatostatin hormone PMID: 21880149
33. the role of endogenous CST is different from SST; CST exerted an unexpected stimulatory role on prolactin secretion PMID: 21971153
34. Data show that gastric infection and inflammation is associated with increased IFNgamma expression and reduced ghrelin expression, and that IFNgamma does not directly control ghrelin expression but inhibits it indirectly via somatostatin. PMID: 21912454
35. Data from studies on islets of Sst knockout mice suggest that paracrine interactions between delta- and alpha-cells provide intra-islet Sst-mediated paracrine communication that facilitates release of glucagon in response to sympathetic activation. PMID: 21099335
36. investigation of role of somatostatin and somatostatin receptors in sexually dimorphic pattern of growth hormone expression in fasting/fed states; studies in hypothalamus, pituitary, and stomach; studies with male and female SST-knockout mice PMID: 20943754
37. Somatostatin secretion is greatly facilitated by cell-to-cell interactions and E-cadherin expression. PMID: 20637727
38. Data show that approximately 95% of mouse olfactory bulb somatostatin-immunoreactive cells describe a homogeneous population of interneurons. PMID: 20394054
39. Extraovarian somatostatin, acting through its receptors 2 and 5 present on granulosa cells, may be involved in mouse folliculogenesis by reducing recruitment of resting follicles. PMID: 20056831
40. opposite and stage-specific effects on the migration of cerebellar granule cells PMID: 11780120
41. Somatostatin acts as a selective chemoattractant for immature hematopoietic cells PMID: 11823046
42. substance P and somatostatin are temporally expressed in granulomas associated with murine cysticercosis, which may be related to differential expression of Th1 and Th2 cytokines PMID: 12117965
43. Brain somatostatin receptors 1,2,4 and 5 are up-regulated in somatostatin-deficient mice, and SSTR3 is down-regulated. PMID: 12145348
44. adrenomedullin, acting via intramural fundic neurons, stimulates somatostatin and thus inhibits histamine and acid secretion PMID: 12573799
45. Somatostatin regulates ductal bile formation in mice by inhibition of ductal fluid secretion, also by stimulation of ductal fluid absorption via interacting with SSTR2 on cholangiocytes, a process involving the intracellular cAMP/cGMP second messengers. PMID: 12676656
46. In whole area of hippocampus, NPY-, SOM- (somatostatin), CCK-, and VIP-positive neurons accounted for about 31%, 17%, 7%, and 8% of GABAergic neurons, respectively. PMID: 12746872
47. Infrequent colocalization of nNOS and somatostatin in mouse hippocampus. Double-labeled cells may be particular subpopulation of hippocampal GABAergic nonprincipal neurons. PMID: 15026120
48. In embryonic kidneys, SRIF is expressed first at the interface of the metanephric mesenchyme and basolateral ureteric bud and later in maturing thin descending limbs of Henle. Expression in the thin descending limb persists in the adult kidney. PMID: 15496149
49. In the hippocampus of a transgenic Alzheimer's disease model at 6 months of age, the expression of somatostatin (SOM) and NPY neuropeptides displayed a significant decrease PMID: 16271420
50. Somatostatin inhibits oxidative respiration in pancreatic beta-cells PMID: 16357046

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Secreted.

Somatostatin family

In the pancreas, somatostatin is expressed in delta cells of the islets of Langerhans. In the stomach, it is expressed in parietal cells of oxyntic mucosa and in the small intestine, it is found in the villus (at protein level). Neuronostatin is expressed

KEGG: mmu:20604

STRING: 10090.ENSMUSP00000004480

UniGene: Mm.2453