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  4. Mouse beta cellulin,BTC ELISA Kit

Mouse beta cellulin,BTC ELISA Kit

  • 中文名称：
    小鼠β细胞素(BTC)酶联免疫试剂盒
  • 货号：
    CSB-E07307m
  • 规格：
    96T/48T
  • 价格：
    ￥3800/￥2500
  • 其他：

产品详情

  • 别名：
    Btc ELISA kit; BcnProbetacellulin [Cleaved into: Betacellulin ELISA kit; BTC)] ELISA kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 样本类型：
    serum, plasma,tissue homogenates
  • 检测范围：
    62.5 pg/ml -4000 pg/ml
  • 灵敏度：
    15.6 pg/ml
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Signal Transduction
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
  • 基因功能参考文献：
    1. Betacellulin promotes the proliferation of corneal epithelial stem cells through the phosphorylation of Erk1/Erk2. PMID: 29331377
    2. The results of this study suggested a novel regulatory role of Btc in axon-Schwann cell interactions involved in myelin formation and nerve repair. PMID: 28139851
    3. BTC induces expansion of neural stem cells and neuroblasts, and promotes neurogenesis in the olfactory bulb and dentate gyrus. PMID: 22232668
    4. Betacellulin exerts proliferative activity on beta cells through the activation of ErbB-1 and ErbB-2 receptors PMID: 21897861
    5. BTC overexpression enhances glucose-induced insulin secretion in Mesenchyma Stem Cells PMID: 20836700
    6. Betacellulin protects from pancreatitis by activating stress-activated protein kinase. PMID: 20038432
    7. Excess of betacellulin exerts no deleterious effects on the structure or function of the male reproductive tract in mice. PMID: 19931240
    8. structure of the BTC gene PMID: 12031500
    9. Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. PMID: 12773386
    10. Mice overexpressing BTC exhibit high early postnatal mortality, reduced body weight gain, impaired longitudinal growth, cataract, retinal and bone abnormalities, and lung disease. PMID: 16179416
    11. identified hitherto unknown effects of betacellulin (BTC) overabundance in reproduction and suggests BTC as a novel candidate protein for the modulation of fertility. PMID: 17914071
    12. role of BTC in the regulation of epidermal homeostasis, hair follicle morphogenesis and cycling, and wound angiogenesis PMID: 17960175
    13. Overexpression of BTC results in an EGFR-dependent upregulation of cortical bone mass in the appendicular skeleton of mice. PMID: 19049329
    14. Long-term BTC overabundance does not alter pancreatic islet structure and beta-cell mass, but enhances glucose-induced insulin secretion in vivo as well as in vitro. PMID: 19100309
    15. Reversal of streptozotocin-induced hyperglycemia by continouous supply of Btc. PMID: 19378417

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  • 亚细胞定位：
    [Betacellulin]: Secreted, extracellular space.; [Probetacellulin]: Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Found in several mouse tissues including kidney, uterus and liver, as well as in beta tumor cell line and MCF-7 cells. It is not detected in the brain.
  • 数据库链接：

    KEGG: mmu:12223

    STRING: 10090.ENSMUSP00000112765

    UniGene: Mm.2024