Mouse soluble Lectin-like Oxidized Low Density Lipoprotein Receptor-1(sLOX-1)ELISA Kit

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.

1. The analysis also revealed that OLR1 is not required for the transcriptional regulation induced by oxidized PAPC but interestingly, OLR1 knockdown affected expression of CNN2, HMRR, ITGB6 and KIF20A, all genes governing cell proliferation and motility. PMID: 29103984
2. Reduced expression of miR-98 may relate to LOX-1 expression and foam cell formation and lipid accumulation in aortas of ApoE(-/-) mice. PMID: 29549823
3. hyperoside inhibits oxLDL-induced LOX-1 expression, ERK activation, and cell proliferation through the oxLDL-LOX-1-ERK pathway in VSMCs. PMID: 28434118
4. data revealed that miR-let-7g exhibits anti-atherosclerotic activity, at least partially by targeting the LOX-1 signaling pathway. PMID: 28535009
5. Adiponectin, TNF-alpha, and LOX-1 exert complex regulatory effects on the coronary microvascular endothelial function in atherosclerotic ApoE knockout mice. PMID: 27050429
6. LOX-1 in cardiomyocytes plays an important role in the pathology of doxorubicin-induced cardiomyopathy. LOX-1 deletion altered the LOX-1-related signaling pathway, which led to improvements in cardiac function, myocardial inflammation, fibrosis and degenerative changes after DOX treatment. PMID: 27195769
7. Enzymatically modified low-density lipoprotein promotes foam cell formation in smooth muscle cells via macropinocytosis and enhances receptor-mediated uptake of oxidized low-density lipoprotein. PMID: 27079883
8. Therefore we concluded that HNG could inhibit ox-LDL-induced macrophage-derived foam cell formation, which occurs because of a decrease in lipid uptake and an increase in cholesterol efflux from macrophage cells. PMID: 27815075
9. The study indicated that the LOX-1/ox-LDL system in chondrocytes plays a role in the pathogenesis of age-related knee knee osteoarthritis, which is potentially a target for preventing knee osteoarthritis progression. PMID: 28348422
10. We demonstrated that varenicline upregulates expression of LOX-1 and CD36 significantly through alpha7 nAChR, thereby promoting oxLDL uptake in macrophages. PMID: 28202387
11. this study shows that LOX-1 can regulate inflammation through regulation of generation of reactive oxygen species in in Aspergillus fumigatus keratitis PMID: 27694040
12. The in vitro and in vivo models revealed that lipid metabolism disorder and FK506 caused oxidative stress and a fibrogenic response. In addition, decreased levels of LOX1 markedly reduced the levels of TGFb1 in the in vitro model. PMID: 27633115
13. LOX-1/ox-LDL system plays a pivotal role in the pathogenesis of instability-induced osteoarthritis through endochondral ossification. PMID: 26901593
14. LOX1 is implicated in OxLDLinduced oxidative stress of macrophages in atherosclerosis, which in part, involves the regulation of NADPH oxidases. PMID: 26165515
15. LOX-1 is, at least in part, responsible for the inhibitory effect of ox-LDL on macrophage migration and this process involves calpain-1 and -2. PMID: 26393906
16. mice with LOX-1 deletion given similar infusion of angiotensin II showed much less rise in blood pressure, and less expression of NADPH oxidase, activation of P38 MAPK and nuclear factor-kappaB, autophagy-related proteins and TLR4 than wild-type mice. PMID: 25380158
17. LOX-1 plays an important role in ischemia-induced angiogenesis by 1) Nox2-ROS-NF-kappaB activation, 2) upregulated expression of adhesion molecules: VCAM-1 and LOX-1 and 3) promoting macrophage infiltration. PMID: 25514797
18. Our findings indicate the novel involvement of LOX-1 in physiological bone homeostasis and inflammatory bone diseases. PMID: 25744064
19. LOX-1 activation by oxLDL is an important event that enhances tumor angiogenesis PMID: 25170920
20. our results indicate that LPS up-regulates LOX-1, at least in part through activation of the Erk1/2 signaling pathway,thus highlighting a critical role of TLR4-mediated aberrant LOX-1 signaling in the pathogenesis of atherosclerosis PMID: 25348362
21. data indicated that olmesartan may attenuate the impairment of endothelial cell via down-regulation of the increased LOX-1 expression induced by ox-LDL. PMID: 22408405
22. findings suggest that LOX-1 participates in angiogenesis in hypertension, which may be related to a state of inflammation. PMID: 25005756
23. Hcy-induced atherosclerosis was closely associated with induced hypomethylation status in the blood vessel, and this process was partially mediated by LOX-1 DNA methylation. PMID: 24938465
24. observations indicate that LOX-1 plays a key role in mtDNA damage which then leads to NLRP3 inflammasome activation during inflammation PMID: 25130466
25. expression of LOX-1 within the atherosclerotic lesions and generation of superoxide in mouse aorta were also significantly reduced by celastrol while the lipid profile was not improved PMID: 23799016
26. ox-LDL-induced bmMSC migration and adhesion are dependent on LOX-1 activation and MCP-1 expression PMID: 23956504
27. Arsenic upregulates LOX-1 expression through the reactive oxygen species-mediated NF-kappaB signaling pathway, followed by augmented cellular oxLDL uptake in mouse aortic endothelial cells. PMID: 24145059
28. LOX-1 contributes, at least in part, to the process of fibroblast senescence and may be viewed as a new aging maker. PMID: 23648807
29. new data on macrophage trafficking in aortas of LDLr KO mice given high cholesterol diet; trafficking appears to preferentially take place in adventitial layers; blockade of macrophage trafficking in aortas of wild type and LDLr KO mice by LOX-1 deletion suggests LOX-1 expression and its upregulation by high cholesterol diet are key events in this process PMID: 24036126
30. Investigated the role of the surface-associated GroEL in the binding of E. coli to macrophages. Results showed that GroEL on E. coli was recognized by LOX-1 on macrophages, leading to the phagocytosis of pathogen by macrophages. PMID: 23085345
31. LOX-1 is a key modulator among multiple mechanisms underlying renal dysfunction following extensive myocardial infarction. PMID: 22673889
32. Lox-1 plays a major role in hypoxia-induced foam cell formation which is, at least in part, mediated by HIF-1alpha. PMID: 23706521
33. LOX-1 abrogation induces MSR1 and inhibits CD36 expression PMID: 23333385
34. SAA stimulates foam cell formation via LOX1 induction, and thus likely contributes to atherogenesis. PMID: 23454129
35. These findings implicate LOX-1 in cytoskeletal organization and growth of cardiac fibroblasts. PMID: 23045471
36. LOX-1 deletion reduces oxidative stress and related intracellular signaling, which leads to attenuation of the positive feedback loop involving AT1R and LOX-1. This results in reduced chronic cardiac remodeling. PMID: 21938018
37. changes in aged endothelial cells are suggestive of aberrant responses to stimuli resulting in a less permissive environment for tissue remodeling and progression of diseases requiring angiogenesis and cell adhesion in elderly, possibly, mediated by LOX-1 PMID: 21698300
38. OLR1 may act as an oncogene by activation of NF-kB target genes responsible for proliferation, migration and inhibition of apoptosis and de novo lipogenesis genes. PMID: 21637860
39. LOX-1 is expressed in neutrophils. LOX-1 deletion prevented neutrophil overreaction and increased neutrophil recruitment to infection sites after sepsis induction. PMID: 21576343
40. Delineate a clearer path from OxLDL through the endothelial cell LOX-1 receptor, RhoA, and ROCK, to the activation of arginase II, downregulation of NO, and vascular dysfunction in atherosclerosis. PMID: 21130456
41. LOX-1 induced by reactive oxygen species and/or peroxynitrite could be one mechanism by which stress promotes cardiovascular disease PMID: 20666645
42. LOX-1 upregulation has a central role in cardiomyocyte hypertrophy response to angiotensin II. PMID: 20422739
43. Results demonstrate that LOX-1 functions as a receptor for Hsp60. PMID: 20631313
44. reciprocal regulation between adiponectin and LOX-1 amplifies oxidative stress and oxidized LDL uptake, leading to endothelial dysfunction in atherosclerosis. PMID: 20581092
45. CD4(+)CD25(+)regulatory T cells-mediated suppression of the monocyte response to oxidized low-density lipoprotein was reflected by a reduction in the up-regulation of NF-kappaB activity accompanied by a decreased expression of TLR2. PMID: 20511710
46. LOX-1 is required for the high-fat diet -induced expression of proinflammatory cytokines in the adipose tissue of obese mice. PMID: 20599751
47. Cooperative engagement of activator protein-1 and nuclear factor (NF)-kappa B by oxidized low density lipoprotein (oxLDL) may constitute a mechanism of increased transcription of inflammatory cytokines within atherosclerotic lesions. PMID: 20489162
48. LPS given ip induced a rapid and robust increase in LOX-1 expression in mouse lung. Pre-treatment with anti-LOX-1-blocking antibody significantly inhibited LPS-induced lung inflammation as indicated by decreased neutrophil accumulation in the lung. PMID: 20375593
49. Alloimmunw responses induce up-regulation of LOX-1 mRNA in transplanted hearts. PMID: 15561273
50. The essential role of cytoplasmic sequences of LOX-1 for cell-surface sorting is established. PMID: 15935375

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Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted.

KEGG: mmu:108078

STRING: 10090.ENSMUSP00000032265

UniGene: Mm.293626