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  4. Rat Apolipoprotein A5(apo-A5)ELISA Kit

Rat Apolipoprotein A5(apo-A5)ELISA Kit

  • 中文名称：
    大鼠载脂蛋白A5(apo-A5)酶联免疫试剂盒
  • 货号：
    CSB-E16334r
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：
        APOA5是一种由APOA5基因编码的蛋白质，是一种高密度脂蛋白（HDL）相关蛋白质。它主要通过调节脂质代谢来影响血液中三酰甘油（TG）水平。APOA5与APOC3和APOA4一起，通过协同作用来调节血液中TG的水平。APOA5还与非酯化胆固醇（NEFA）代谢和胰岛素抵抗有关。APOA5缺陷可能会导致高TG水平，这是代谢综合征、脂质代谢异常和心血管疾病的风险因素。因此，APOA5成为了心血管疾病风险评估和治疗的潜在靶点。
        j9九游会登录入口首页生物所提供的Rat Apolipoprotein A5(apo-A5)ELISA Kit属于ELISA检测试剂盒，采用竞争法定量检测大鼠血清、血浆、组织匀浆样本中的APOA5 
  • 别名：
    Apoa5 ELISA kit; Rap3Apolipoprotein A-V ELISA kit; Apo-AV ELISA kit; ApoA-V ELISA kit; Apolipoprotein A5 ELISA kit; Regeneration-associated protein 3 ELISA kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Rattus norvegicus (Rat)
  • 样本类型：
  • 检测范围：
  • 灵敏度：
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cancer
  • 测定原理：
    quantitative
  • 测定方法：
    Competitive
  • 精密度：
     
  • 线性度：
     
  • 回收率：
     
  • 标准曲线：
     
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
        APOA5是一种与三酰甘油代谢和心血管疾病风险密切相关的蛋白。最新的研究表明，APOA5可能还具有调节肝细胞脂代谢和炎症反应的作用。一项发表在Journal of Lipid Research上的研究发现，APOA5通过调节脂代谢酶基因的表达，影响肝脏脂质代谢和三酰甘油的水平。此外，一些研究还发现，APOA5与胰岛素抵抗、非酒精性脂肪肝等疾病有关。
  • 功能：
    Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin.
  • 基因功能参考文献：
    1. Our data support the hypothesis that apoA5 promotes hepatic TG storage and therefore contributes to the pathogenesis of non-alcoholic fatty liver disease PMID: 25938357
    2. Demonstrate that apoA-V is secreted into bile, introducing a potential route of delivery of hepatic apoA-V to the gut lumen. PMID: 26505974
    3. The increase in apolipoprotein A mRNA induced by rosiglitazone is not directly mediated by peroxisome proliferator-activated receptor gamma.[apolipoprotein av] PMID: 16570166
    4. apoA-V inefficiently traffics within the secretory pathway, that its intracellular itinerary can be regulated by changes in cellular TG accumulation, and that apoA-V synthesis can modulate VLDL TG mobilization and secretion. PMID: 21115968
    5. decreased apolipoprotein A5 is implicated in insulin resistance-related hypertriglyceridemia in obesity PMID: 20047745
    6. ApoA-V ability to enhance insulin secretion in beta-cells and provide evidence of an internalization pathway involving the midkine as partner. PMID: 19910685
    7. the hypotriglyceridemic gene APOA5 is regulated by thyroid hormone PMID: 15941710
    8. The absence of significant changes in Apoa5 gene expression during chronic fructose-induced triglyceride elevation excludes its major role in mechanisms compensating severe hypertriglyceridemia PMID: 16238453
    9. data suggest that the C terminus of apoA-V is essential for lipid droplet association in transfected hepatoma cells and lipoprotein association in conditioned medium while the signal peptide is required for extracellular trafficking of this protein. PMID: 18450648

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  • 亚细胞定位：
    Secreted. Early endosome. Late endosome. Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    Apolipoprotein A1/A4/E family
  • 组织特异性：
    Liver.
  • 数据库链接：