Rat Bone morphogenetic protein 2,BMP-2 ELISA Kit

Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Stimulates also the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation.

1. study suggests that NT-3 may be an osteogenic and angiogenic factor upstream of BMP-2 and VEGF in bony repair, and further studies are required to investigate whether NT-3 may be a potential target for preventing growth plate faulty bony repair or for promoting bone fracture healing. PMID: 26763079
2. The synergistic effect of BMP-2+phenamil on bone regeneration was further confirmed in a critical-sized rat mandibular bone defect by implanting polymer scaffolds designed to slowly release the therapeutic molecules. PMID: 27771997
3. IGFBP4 overexpression impaired BMP2-induced osteogenic differentiation potential of young MSCs, whereas IGFBP4 knockdown restored the osteogenic potency of aged MSCs. Moreover, IGFBP4 knockdown stimulated the activation of Erk and Smad by increasing phosphorylation. PMID: 28595186
4. Data suggest that Cox2/Ptgs2 (cyclooxygenase-2) plays role in exacerbated of activation of Bmp2 (bone morphogenetic protein 2) signaling in pulmonary microvascular endothelial cells; this promotes macrophage activation/accumulation and pathological angiogenesis in lung in a rat model of hepatopulmonary syndrome. PMID: 28642034
5. downregulation of Bmpr1a and Bmp2 at the time of cloacal separation into the primitive rectum and UGS might be related to the development of anorectal malformations. PMID: 27477499
6. 50% ethanol extracts of root-bark of Sambucus Williamsii Hance can accelerate fracture healing by recruitment of osteoblasts at the fracture site and through up-regulation of the BMP-2 signaling pathway. PMID: 27178636
7. A short-term zinc-deficient diet decreases bone formation through down-regulated BMP2 in rat femurs. PMID: 26931551
8. NF-kappaB stimulates BMP-2 mRNA expression in rat and human beta cells upon IL-1b cytokine exposure. PMID: 26308798
9. Gelatinases promote vascular calcification by upregulating BMP-2 which induces expression of RUNX2 and Msx-2, two proteins associated with phenotype transition of VSMCs in vascular calcification. PMID: 26797522
10. establish the feasibility of combining NELL-1 with BMP2 to improve clinical bone regeneration and provide mechanistic insight into canonical Wnt pathway activity during NELL-1 and BMP2 osteogenesis PMID: 26772960
11. spinal cord injury(SCI) can cause severe impairment of motor activity in rats. Seven days after SCI, the local expression of BMP-2/4 had obviously increased; noggin can effectively inhibit the expression of BMP-2/4 and reduce impairment PMID: 26345843
12. findings describe a positive regulatory effect of LMP-1 on BMP-2 expression and BMP-2-mediated osteogenesis. This effect occurs through activation of ERK1/2 pathway and subsequent upregulation of Runx2 transactivity. PMID: 25677945
13. VDR may mediate the increased expression levels of BMP2, Runx2 and Osterix by positively regulating calcium levels in primary primary renal tubular epithelial cells. PMID: 25823394
14. EPCs-BMP2 further improved endothelium repair. PMID: 25896232
15. ERRgamma plays a key role in vascular calcification by upregulating the BMP2 signaling pathway. PMID: 26404484
16. Dexamethasone augmented ectopic bone formation induced by bone morphogenetic protein-2. PMID: 25659106
17. the BMP-2-SMAD-5 pathway has a role in hydroxyapatite differentiation of aortic smooth muscle cells into osteoblast-like cells PMID: 25725805
18. On day 21, 50 ng/mL BMP2/7 could antagonize the inhibitive effects of ATRA and significantly enhance osteogenesis of bone marrow stromal cells. PMID: 24111806
19. these data provide evidence for BMP-2 as a new autocrine/paracrine factor that regulates cardiomyocyte mechanotransduction and adaptation to increased mechanical stretch. PMID: 25218476
20. Knockdown of BMP2 or Noggin blocked phosphate-induced calcification. PMID: 25446167
21. Osteogenic differentiation was significantly promoted in the triple combination treatment of BMP-2, VEGF and bFGF compared with the single or binary combination treatments. PMID: 24306516
22. BMP2 is a potential regulator of nigrostriatal pathway development. PMID: 24682653
23. The data indicated that inhibition of Smad4 diminished both AdBMP2 induced and basal histone acetylation levels in the promoter regions of GATA4 and Nkx2.5. PMID: 24866243
24. Endothelial progenitor cell therapy can promote fracture healing and this may occur by increasing BMP-2 levels and thus stimulating angiogenesis and osteogenesis. PMID: 24464097
25. IGF-1 and BMP-2 together mediate PGE2-induced adipogenic differentiation of tendon stem cells in vitro via a CREB- and Smad-dependent mechanism. PMID: 24416413
26. Inhibition of histone H3 acetylation diminishes BMP2-induced expression of GATA binding protein 4 and myocyte enhancer factor (MEF)2C in cardiac myocytes. PMID: 23632743
27. incorporation of nanostructured colloidal gelatin gels capable of time- and dose-controlled delivery of BMP-2 and FGF-2 in porous titanium scaffolds is a promising strategy to enhance and continue bone regeneration of large bone defects. PMID: 23822814
28. Ectopic bone formation assays at subcutaneous sites in rats demonstrated that HA hydrogel-delivered BMP-2 precomplexed with GAG induced twice the volume of bone compared with BMP-2 delivered uncomplexed to GAG. PMID: 24167632
29. The study provides novel evidence that 1,25-dihydroxyvitamin D3 represses bone formation through down-regulating BMP2 expression both in vivo and in vitro. PMID: 23620751
30. Gene transfer of the calcification inducer BMP2 gene to the trabecular meshwork induces elevated IOP in living rats without altering the basic structure of the tissue. PMID: 23821199
31. Quantitative real-time PCR (RT-qPCR) and enzyme-linked immunosorbent assay (ELISA) demonstrated that lyophilized BMP-2/CDHA construct with trehalose (lyo-tre-BMP-2) promoted osteogenic differentiation of bone marrow stromal cells (bMSCs) signific PMID: 23359400
32. Mechanical loading further enhanced the efficacy of BMP2 application evidenced by increased mineralized tissue volume and mineralization at the stage of bony callus bridging. PMID: 22861354
33. Therefore, cell-specific ECMs are capable of modulating the BMP-2-induced osteogenic and chondrogenic differentiation of hMSCs. PMID: 23088504
34. Overall, the results demonstrated that the combination of injectable nCS/A paste and BMP2-gene-modified MSCs is a new and effective strategy for the repair of bone defects. PMID: 22994418
35. BMP2 participates in regulating Ca(2+) signaling in pulmonary arterial smooth muscle cells by inhibiting TRPC1, TRPC4, and TRPC6 expression. PMID: 23447035
36. The effect of BMP-2 on tendon derived stem cells might provide insights into the histopathological changes of tendinopathy. PMID: 23238867
37. SHP is a downstream factor of BMP2 signaling in odontoblasts and may stimulate dentin matrix mineralization via enhancing the transcriptional activity of Dlx5. PMID: 23010719
38. BMP2 and BMP7 have roles in inflammation, but BMP7 has a greater role in soft tissue edema PMID: 22674456
39. analysis of a new approach to promote bone formation using an improved delivery system of bone morphogenetic protein-2 PMID: 22556155
40. demonstrates that the combination of Wnt11 and BMP-2 effectively promotes cardiomyogenic differentiation of BM-MSCs in vitro. The synergistic effect of Wnt11 and BMP-2 on the cardiomyogenic differentiation of BM-MSCs is further enhanced in myocardium PMID: 22829700
41. Diabetes is associated with an abnormal BMP/MAD homolog Smad signaling expression in the myenteric ganglia that affects the homeostasis of the enteric plexus. PMID: 21737358
42. BMP-2 suppresses renal interstitial fibrosis by regulating epithelial-mesenchymal transition PMID: 21590708
43. It contributes to aortic valve caldification in aged rats. PMID: 21157119
44. Bone morphogenetic protein-2 binds to cartilage oligomeric matrix protein, resulting in inhibition of vascular smooth muscle calcification. PMID: 21350216
45. These results suggest that SDF-1 increases the number of osteoprogenitor cells that are mobilized from the bone marrow and then home to the implant. PMID: 21043834
46. Simvastatin increased the expression of BMP2 in the periodontal tissue after orthodontic tooth movement. PMID: 18380969
47. Activation of BMP-2 expression in tendon derived stem cells during tendon overuse might provide a possible explanation of ectopic calcification in calcifying tendinopathy PMID: 20882582
48. This study indicated that BMP2 is more widely expressed throughout the adult CNS than previously reported, and its continued abundant expression in the adult brain strongly supports the idea that BMP2 also plays pivotal roles in the adult brain. PMID: 20886619
49. Down-regulation of IL-1beta is associated with cartilage repair in the pathological features of osteoarthritis. PMID: 20939479
50. Chronic hypoxia induced an increased expression of BMP-2 in endothelial cells. BMP-2 may play an important role in the pathogenesis of hypoxic pulmonary hypertension. PMID: 18070548

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Secreted.

TGF-beta family

Expressed in femur, calvaria, trachea, lung and ovary.

KEGG: rno:29373

STRING: 10116.ENSRNOP00000028904

UniGene: Rn.90931