Your Good Partner in Biology Research

  1. 首页
  2. 试剂盒
  3. 酶联免疫试剂盒
  4. Rat Cystatin C,Cys-C ELISA Kit

Rat Cystatin C,Cys-C ELISA Kit

  • 中文名称：
    大鼠半胱氨酸蛋白酶抑制剂/胱抑素C(Cys-C)酶联免疫试剂盒
  • 货号：
    CSB-E08385r
  • 规格：
    96T/48T
  • 价格：
    ￥3900/￥2500
  • 其他：

产品详情

  • 产品描述：
        CST3（半胱氨酸蛋白酶抑制剂）是一种广泛存在于人类组织中的天然蛋白酶抑制剂，可抑制多种蛋白酶的活性。它对多种蛋白酶如半胱氨酸蛋白酶、胰蛋白酶等有抑制作用，并且可以调节一些重要的生物学过程，如凝血、纤溶、炎症、组织再生等。
        j9九游会登录入口首页生物所提供的Rat Cystatin C,Cys-C ELISA Kit属于ELISA检测试剂盒，采用双抗夹心法定量检测大鼠 血清、血浆、匀浆.样本中的CST3，其灵敏度为0.078 ng/ml，检测范围为0.312 ng/ml-20 ng/ml。
     
  • 别名：
    Cst3 ELISA Kit; Cystatin-C ELISA Kit; Cystatin-3 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Rattus norvegicus (Rat)
  • 样本类型：
    serum, plasma, homogenates
  • 检测范围：
    0.312 ng/ml-20 ng/ml
  • 灵敏度：
    0.078 ng/ml
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cardiovascular
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：

      

  • 线性度：

      

  • 回收率：

      

  • 标准曲线：

       

  • 数据处理：
  • 货期：
    3-5 working days

引用文献

产品评价

靶点详情

  • 最新研究进展：
    CST3是一种由人体细胞产生的小分子蛋白质，也被称为半胱氨酸蛋白酶抑制剂或淀粉样蛋白沉积物抑制剂。它在细胞凋亡、免疫调节、组织修复和生殖系统发育等方面发挥重要作用。最近的研究表明，CST3与多种疾病有关，包括神经退行性疾病、肾脏疾病和肿瘤。
     
  • 功能：
    As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Known to inhibit cathepsin B, H, and L.
  • 基因功能参考文献：
    1. Tanshinone IIA protects against cardiac hypertrophy in spontaneously hypertensive rats by inhibiting the Cys-C/Wnt signaling pathway. PMID: 28053285
    2. These results indicate that Cd increases the urinary excretion of cystatin C, and they suggest that this effect may involve disruption of megalin-mediated uptake of cystatin C by epithelial cells of the proximal tubule. PMID: 26715107
    3. High cystatin C is associated with proteinuria. PMID: 21551085
    4. Triiodothyronine-induced increase in the production of cystatin C may be related to an increased cell metabolism and proteolysis control demand. PMID: 22360852
    5. CysC plays a protective role under conditions of neuronal challenge by inducing autophagy via mTOR inhibition PMID: 20352108
    6. Oxidants induce elevated cystatin C production from cardiac myocytes. Cystatin C plays a role in cardiac extracellular matrix remodelling. PMID: 20489058
    7. We found several novel glycoforms of cystatin c in rat hippocampal stem cells, suggesting that N- and O-linked glycans with sialic acid are attached to cystatin C. PMID: 15197734
    8. These results demonstrate that cystatin C has protective effects against various oxidative stresses that induce cell death. PMID: 16140167
    9. endometrial expression of the cysteine protease inhibitor, Cst3, is modulated by estrogen during the peri-implantation period PMID: 16935259
    10. These studies suggest alternate pathways and potential therapeutic targets of cell death associated with oxidative stress, CC, and lysosomal dysregulation. PMID: 17241700
    11. Finally, in vivo studies using kidney-specific megalin knockout mice provide evidence that megalin mediates proximal tubular uptake of cystatin C. We conclude that megalin is an endocytic receptor of cystatin C in PTC. PMID: 17462596

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Cystatin family
  • 数据库链接：