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  4. Rat Insulin-like growth factor binding protein 5,IGFBP-5 ELISA kit

Rat Insulin-like growth factor binding protein 5,IGFBP-5 ELISA kit

  • 中文名称：
    大鼠的胰岛素样生长因子结合蛋白5(IGFBP-5)酶联免疫试剂盒
  • 货号：
    CSB-E12784r
  • 规格：
    96T/48T
  • 价格：
    ￥3200/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Rat IGFBP5 ELISA Kit was designed for the quantitative measurement of Rat IGFBP5 protein in serum, plasma,tissue homogenates. It is a Sandwich ELISA kit, its detection range is 0.312 ng/mL-20 ng/mL and the sensitivity is 0.078 ng/mL.

  • 别名：
    Igfbp5 ELISA Kit; Igfbp-5 ELISA Kit; Insulin-like growth factor-binding protein 5 ELISA Kit; IBP-5 ELISA Kit; IGF-binding protein 5 ELISA Kit; IGFBP-5 ELISA Kit
  • 缩写：
    IGFBP5
  • Uniprot No.：
  • 种属：
    Rattus norvegicus (Rat)
  • 样本类型：
    serum, plasma,tissue homogenates
  • 检测范围：
    0.312 ng/mL-20 ng/mL
  • 灵敏度：
    0.078 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Signal Transduction
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • 基因功能参考文献：
    1. Insulin growth factor binding protein 5 (IGFBP-5), insulin growth factor (IGF-1) and transforming growth factor (TGF-beta1) in the type II alveolar epithelial cells (AECs) play a key role in lung injury caused by bleomycin and pioglitazone attenuates the lung injury/fibrosis by restoring IGFBP-5 and IGF-1 and decreasing TGF-beta1 expressions in the type II AECs. PMID: 28077319
    2. Silencing IGFBP5 with small interfering RNA significantly reduced apoptosis and suppressed the expression of caspase3 in neonatal rat ventricular myocytes following treatment with methamphetamine. PMID: 25230843
    3. IGFBP5 expression was up-regulated in the striatum of methamphetamine exposed male Sprague-Dawley rats. PMID: 25127757
    4. IGFBP5 mediates high glucose-induced cardiac fibroblast activation PMID: 23417767
    5. IGFs/IGFBPs may have important roles not only in fracture healing but also in nonunion formation. PMID: 21598309
    6. Insulin-like growth factor-binding protein-5-induced laminin gamma1 transcription requires filamin A. PMID: 20167606
    7. Downregulation of IGFBP-5 gene expression may cause pulmonary hypoplasia in the nitrofen-induced CDH model by interfering with retinoid signaling pathway. PMID: 19844724
    8. Chronic exposure to high glucose leads to impaired mesangial cell migration in response to IGFBP-5 as a result of loss of laminin beta2 protein. PMID: 19864299
    9. plays an important role in the development of the anterior pituitary gland PMID: 12006713
    10. findings indicate that the modulation of rat ovarian insulin-like growth factor binding protein-4 and -5 is protein kinase C as well as protein kinase A dependent PMID: 12193414
    11. IGFBP-3 and -5 proteins may have potential modulatory roles in type I fiber-dominated muscles, aging, and regrowth from atrophy. PMID: 12397024
    12. Specific amino acid substitutions determine the differential contribution of the N- and C-terminal domains of insulin-like growth factor (IGF)-binding protein-5 in binding IGF-I PMID: 12626499
    13. Overexpression of rat IGFBP-5 in transduced murine MC3T3 osteoblasts decreases osteoblastic function possibly by binding insulin-like growth factors in the bone microenvironment. PMID: 15589207
    14. IGF-I uses different and only partially overlapping intracellular signaling pathways for regulation of IGFBP-3 and -5 with opposing biological functions might be important for modulation of IGF bioactivity in cellular microenvironment. PMID: 15845624
    15. Although IGFBP-5 overexpression did not have an IGF-independent effect on RCJ cell differentiation, it promoted IGF-I-enhanced differentiation of these cells. PMID: 16204335
    16. Inflammatory insults decrease muscle IGFBP-5 mRNA by a TNF-dependent glucocorticoid-independent mechanism. IGF-I appears to be a dominant positive regulator of IGFBP-5 gene expression in muscle under both normal and catabolic conditions. PMID: 16339387
    17. Unique function for the laminin-9 complex in mediating IGFBP-5-induced migration. PMID: 16672690

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Mostly in kidney.
  • 数据库链接：

    KEGG: rno:25285

    STRING: 10116.ENSRNOP00000023530

    UniGene: Rn.1593